Betmiga tablets belong to the group of selective beta3-adrenoreceptor agonists. The drug affects the urinary system, in particular smooth muscles. With regular use, muscle tone decreases. Betmiga tablets of 50 mg are allowed to be used strictly under the supervision of the attending physician, on his recommendation. With self-medication, the likelihood of complications is high. In pharmacies, the sale of the drug is allowed only with a prescription.
What is this about?
Betmiga belongs to the group of long-acting drugs. Each tablet is enclosed in a film shell, on which are engraved the symbols of the pharmacological company that made the medicine. Betmiga tablets 50 mg (30 pcs. Per pack) are oval, convex on both sides. Painted in a characteristic brownish color. In the package - one blister or several. There is also necessarily in the package "Betmiga" instructions for use with the manufacturer's recommendations for the use of the medication.
The effectiveness of the intake is guaranteed by the presence of the active substance mirabegron (fully synthetic). The use of the course allows you to achieve a relaxing effect on smooth muscles. The active component decomposes in the liver, excreted through the kidneys.
When and why?
Usually, Betmiga 50 mg is prescribed if the activity of the bladder is much higher than normal, when the patient notes that urination is too frequent. If incontinence is observed, it is urgent to consult a specialist. With such problems, the doctor often prescribes "Betmiga" 50 mg. At the same time, it is not allowed to choose a drug for treatment on their own, not knowing all the features of the body, without information obtained from laboratory tests.
The instructions for the use of Betmiga 50 mg indicate that the medication has a systemic effect, that is, it affects the body as a whole, and not just the target organ. This imposes certain restrictions on its use and forces us to pay particular attention to the list of contraindications.
Instructions for the use of tablets "Betmiga" contains a reference to the impossibility of using the drug in childhood, when bearing a fetus and breastfeeding. In addition, it is unacceptable to use the Betmiga medication for diseases of the kidneys, liver, including their insufficiency. Some people have hypersensitivity, intolerance to synthetic medicines. It also imposes certain restrictions on the possibility of therapy with Betmiga tablets. The instruction contains a reference to a possible allergic reaction, manifested by a rash on the skin.
Accurate use is the key to a good result
Studying the instructions for "Betmiga" 50 mg, you can see that in severe cases of renal failure, taking the medication is possible, but under the supervision of a doctor and with special attention to the patient's condition. In the same way, a remedy is used if an intermittent hypertension is diagnosed. A specific interaction with the CYP3A isoenzyme makes it necessary to use Betmiga tablets with caution in combination with highly effective inhibitors of this compound.
The interaction of the drug with a number of other medicinal substances is known. All of them are mentioned in the instructions for "Betmiga" 50 mg, but it is better to discuss this issue with your doctor. Otherwise, increased activity of the bladder may overlap with complications from taking incompatible medications. The risk of developing an allergic reaction should not be overlooked.
Side effects
Reviews and instructions for "Betmiga" 50 mg contain references to possible side effects. The manufacturer does not hide them, and many who used the medication noted that those who showed themselves to a greater or lesser degree of severity. At the same time, the likelihood of side effects is quite low, since the drug adapts to the human body, so that a correctly selected therapeutic course does not provoke complications.
If side effects still occur, then the main positive quality of the medication - systemicity - becomes a drawback. Negative effects spread to a variety of organs, internal systems. Predicting all possible manifestations is not always possible. This is also evidenced by reviews of Betmiga 50 mg.
Common side effects
From patients' reviews of Betmiga, you can collect information about the following manifestations of negative effects:
- lips swell, dyspepsia appears;
- sore joints become inflamed;
- swollen, itchy skin in the perineum;
- tachycardia, palpitations;
- rash, swelling, redness on the skin;
- pressure surges.
When conducting laboratory monitoring of the patient's condition, one can detect the growth of liver enzymes. In addition, reviews of "Betmiga" 50 mg indicate an increased risk of infectious diseases of the genitourinary system, cystitis.
What to do?
As follows from the instructions for the use of Betmiga 50 mg tablets, if any of the listed symptoms are fixed, it is urgent to consult your doctor and stop taking the medication. As a rule, the doctor chooses an alternative option.
In some cases, it is enough to adjust the dose. This measure is applicable if the cause of intolerance, side effects is in the abnormal, insufficient functioning of the kidneys, liver. It is known that in other cases, a decrease in the dose relative to the recommended does not allow to achieve a lasting long-term positive effect.
How to use?
Reviews about Betmiga 50 mg tablets contain recommendations for taking the drug orally, there is no need to adjust to the schedule of meals or sleep. Many patients agree that it is more convenient to develop an individual convenient schedule for yourself and use tablets at the same time every day.
It is recommended to take a dose of 50 mg at a time, but a halving is possible if pathological disorders of the kidneys and liver are diagnosed. The tablets are washed abundantly with water. The duration of time of intensive care is determined by the doctor, who focuses on the characteristics of the disease. In some cases, it is enough to drink, following the instructions for use, Betmiga tablets 50 mg a couple of days. With more serious health problems, the duration of the course increases to a week or even a month. At the same time, doctors regularly monitor the patient’s condition, take tests to fix the indicators in the laboratory, on the basis of which they decide on completion of therapy or extension of the course. Self-interrupt treatment with Betmiga 50 mg tablets is strictly prohibited by the instructions for use. This will not only nullify the therapeutic effect, but can also cause complications.
Is it possible to replace?
If the patient needs therapy, but Betmiga is not applicable due to contraindications, individual intolerance or other reasons, you will have to resort to analogues. "Betmiga" 50 mg can be replaced with some medications, but which ones, the doctor decides, evaluating the patient's condition.
Often, the need to replace a medicine is provoked by a high price - one package containing 10 tablets costs about a thousand rubles. Inexpensive drugs with a similar effect in the pharmacy are presented in a rather wide variety, but the choice should be discussed with the doctor, since each medication has its own limitations on the use, contraindications and side effects.
List of analogues
Most Popular:
- Spazmeks;
- "Driptan";
- "Roliten."
Reviews: Do you believe it?
Information from patients treated with Betmiga 50 mg tablets (according to the instructions for use) is generally positive. People note that the use of a medicine under the supervision of a specialist and in compliance with all conditions specified by the manufacturer gives good results.
At the same time, the total number of reviews in the Russian-speaking sector of the Internet is small. Presumably, this is due to the high cost of the drug. People tend to save, so they prefer cheap counterparts. Often, doctors immediately write prescriptions for Betmiga tablets and an alternative, inexpensive option.
Betmiga: important features
The use of the drug is not recommended (and this is indicated by the instructions for the use of Betmiga 50 mg tablets) in childbearing age, if the patient is a woman who prefers not to use contraceptives.
With caution, you can use the medication in the treatment of patients who have a longer QT interval from birth or this deviation has appeared over the years. It imposes a certain limitation and therapy with medicines that provoke QT prolongation. Betmiga tablets are used with great caution if the patient undergoes a course of tricyclic antidepressants or is treated for arrhythmias with group 1C drugs.
Betmiga and pressure
It is known that taking medication can provoke an increase in blood pressure. To avoid unpleasant situations, it is necessary to regularly monitor the patient's condition. The usual practice is as follows: make a control measurement of pressure before the start of the course of treatment, then regularly check the indicators already during treatment with tablets.
Particular attention should be paid to pressure indicators if a person with already diagnosed arterial hypertension is undergoing treatment.
Apply carefully
It is known that regular use of the medication according to the instructions does not affect the psyche, motility, cognitive abilities. Therefore, you can undergo therapy, at the same time drive a car, work in potentially dangerous conditions. There are no restrictions.
Drug Interactions
Mirabegron is a weak CYP3A inhibitor, to a greater extent - a CYP2D6 inhibitor. For this reason, the medication affects the transport of drug components through P-glycoprotein (but only with the accumulation of a high dose in the body).
Studies have shown that there are no expected clinically significant results of the interaction with the simultaneous use of "Betmiga" and medications that inhibit CYP, classified as substrates. The situation with isoenzyme transporters is similar. The exception is CYP2D6: at high concentrations, mirabegron affects the metabolism of the compound.
If the liver and kidneys function normally, these effects are considered insignificant and do not affect therapy. With mild, moderate renal, hepatic insufficiency and the use of strong drugs based on itraconazole, clarithromycin and the like for therapy, it is necessary to halve the daily dose of Betmiga tablets.
Very carefully, with regular monitoring of the patient’s condition, Betmiga tablets are used in combination with drugs that affect the metabolism of CYP2D6, and if necessary, prescribe digoxin to the patient. During treatment, the concentration of digoxin in the blood is regularly checked, if necessary, reduce the dose.
Analogue "Spazmeks"
There are three dosage options on sale: 5, 15, 30 mg. The product is classified as an antispasmodic and is one of the most commonly used analogues of Betmiga tablets. A package of 30 tablets costs from 350 rubles, which is about six times cheaper than Betmiga. The main component of the drug is called trospia chloride, effective due to the ability to block m-cholinergic receptors. An antispasmodic additionally has a ganglion blocking effect. The active ingredient is an acetycholine antagonist.
The use of the drug blocks the detrusor, while there is no central effect from taking the pills. The usual indication for the use of the drug is an increased activity of the bladder, an increased frequency of urination. The effectiveness of the reception gives only for non-hormonal, inorganic causes of health problems.
The tool can be used for incontinence in various forms, including mixed. Efficiency has been proven in pathological disorders of the urinary system, expressed in increased activity, detrusor reflection provoked by injuries, stroke, sclerosis, parkinsonism.
The drug is widely used in the treatment of cystitis.
The main contraindication is intolerance to the main active component of trospium chloride. In addition, it is not recommended to use Spazmeks if the patient has disturbances in the functioning of the heart and blood vessels, especially in cases of stenosis, hypertension, arrhythmia, and heart failure.
Very careful use of "Spazmeks" is allowed if diagnosed:
- preeclampsia;
- glaucoma;
- colitis;
- atony;
- Down's disease;
- Cerebral palsy.
The limitation is imposed by a number of other health disorders, including significant pathologies of the kidneys and related organs, neuropathy. During the bearing of the fetus, with lactation, there is no ban on the use of the medication, but its use is undesirable.
Side effects Overdose
Quite rare, but cases of dyspepsia are known, dry mouth is possible. Also, a low share of the probability of side effects from the nervous system, such is expressed by confused consciousness. Less than 1% of patients treated with Spazmex experienced skeletal muscle death. Also categorically rare (but there is a small chance of probability) are cases of accommodation problems.
If the prescribed doses are exceeded, dry mouth and frequent palpitations are possible. In some cases, visual perception suffers, the skin becomes red. To eliminate negative reactions, it is necessary to use m-cholinomimetics. In severe cases of drug poisoning, urgent use of beta-blockers with constant pressure control is necessary.
How to use? Spazmeks is drunk before meals, and plenty of water is drunk. The tablet cannot be chewed, it violates the normal processing in the digestive tract and reduces the effectiveness of the drug. The choice of dose remains with the attending physician, analyzing the patient’s condition, the degree of violation, concomitant therapy and background diseases that affect the characteristics of the drug.
As a rule, Spazmeks is prescribed three times a day, regularly, with an interval of 8 hours between doses. In a day, a total of not more than 45 mg should be ingested. In some cases, unauthorized correction of the regime is allowed - a reduction in the dose relative to the one prescribed by the specialist by half the tablet. This is possible if you suddenly feel worse. An increase of one's own free will is unacceptable, only a specialist can adjust the dose up, justifying his decision. If there are problems with the functioning of the kidneys, the maximum daily dose is reduced to 15 mg. The duration of the course is an average of three months.
Features of application and storage
The main active component of Spazmeks activates quinidine, and also affects the effectiveness of tricyclic antidepressants. In addition, interaction with amantadine, antihistamines, and adrenostimulants is known.
If it is necessary to use Spazmeks in people with problems with the functioning of the sphincter, detrusor, a catheter is required. If the bladder has vegetative deficiencies, it is important to identify the cause of the problem before starting treatment, only then prescribe the drug. Also, before starting treatment, the likelihood of carcinoma and infections must be excluded.
From pharmacies, the drug is dispensed strictly in the presence of a prescription. At home, it is recommended to store the medicine in a place protected from light, cool (15-25 degrees). It is necessary to ensure that there is no access to the drug in children.
Analog "Driptan"
"Driptan" is considered an effective, almost indispensable drug in childhood enuresis, since its use is allowed from an early age. On sale tablets are presented in packs of 30 and 60 pieces. A pack of 30 tablets costs about 700 rubles, which is about three times cheaper than Betmiga.
The drug is available in biconvex round tablets without special coloring (white). One of the sides is marked by a risk for dividing a serving into two.
The main active component of the medication is oxybutynin hydrochloride. In one tablet contains 5 mg. Additional substances contained in the preparation are calcium stearate, cellulose, and lactose.
The drug is classified as an antispasmodic. Oxybutynin effectively relaxes smooth muscles.The substance is opposite in its effect to the effect of acetylcholine, which also positively affects muscles, eliminating cramping. The highest activity "Driptan" is in the detrusor area. Due to the relaxing effect, the product smooths out the unpleasant consequences of instability and increased activity of the bladder. Regular use under the supervision of a doctor eliminates spontaneous contractions, the bladder becomes slightly larger in volume.
When is it possible? And when not?
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Side effects
In general, Driptan is a rather mild drug, but side effects are still possible. The instructions for use of the drug mention:
- nausea;
- craving for sleep;
- constipation
- dry skin;
- headaches;
- dizziness;
- dry mouth.
May delay urination. Dry mucous membranes of the organs of vision are noted. In rare cases, taking the drug provokes vomiting, allergic reactions are possible. With long-term use, the normal production of saliva is disrupted, the likelihood of caries increases.
How to use?
In childhood, "Driptan" is prescribed twice a day for half a tablet. With good tolerance, the dose can be taken at one time at night. The duration of the course is controlled by a doctor.
Exceeding the permissible doses can lead to negative reactions from the nervous system, pressure, respiratory organs. The most severe outcome of an overdose is coma.