What can replace a tool like Arthra MSM Forte? Analogs of this drug will be listed at the end of the article. You will also learn about the form in which this medication is produced, what users say about it, and how to use it correctly if there are indications for use.
Form of drug release, its composition, description and packaging
"Artra MSM Forte" - biconvex tablets, oval, film-coated. They can have a light yellow-orange or dark orange color, as well as a specific smell.
The main ingredients of this medicine are elements such as chondroitin sodium sulfate, methylsulfonylmethane, glucosamine hydrochloride and sodium hyaluronate in the form of hyaluronic acid.
As for the additional components, they include microcrystalline cellulose, croscarmellose sodium, calcium hydrogen phosphate dihydrate, stearic acid, colloidal silicon dioxide and magnesium stearate.
The film coat of the drug in question includes: orange opadra II, talc, triglycerides, maltodextrin, dye yellow sunny sunset.
“Arthra MSM Forte” tablets are on sale in white bottles with a screw cap made of dense polyethylene.
Pharmacodynamic characteristics
What is Arthra MSM Forte? Reviews of experts say that this medication is a stimulant of restoration processes in cartilage tissues. The active ingredients of this drug take part in the synthesis of connective tissues, and also prevent the destruction of cartilage and stimulate the regeneration of its tissues.
The use of exogenous glucosamine significantly enhances the production of cartilage matrix and protects (non-specifically) cartilage from possible chemical damage.
Features of the tool
What are the noteworthy tablets of “Arthra MSM Forte”? The instruction reports that the glucosamine contained in this medicine in the form of a sulfate salt is a kind of precursor to hexosamine. As for the sulfate anion, this substance is necessary for the production of mucopolysaccharides of connective tissue.
One cannot but say that glucosamine has another supposed function. This is the protection of already damaged cartilage tissues from their further destruction, which was caused by the use of GCS or NSAIDs.
What role does chondroitin play in Arthra MSM Forte? According to the instructions, this component performs the work of an additional substrate, which contributes to the formation of a healthy matrix of cartilage.
It should also be noted that chondroitin:
- stimulates the mechanisms of cartilage tissue repair;
- stimulates the synthesis of type II collagen, hyaluronan and proteoglycans;
- inhibits the action of cartilage-breaking enzymes (elastase and hyaluronidase);
- inhibits the activity of free radicals, and also protects hyaluronan from splitting, which is caused by enzymes and the aggressive action of free radicals;
- maintains proper viscosity of synovium.
In addition, in people suffering from osteoarthritis, this substance eliminates the symptoms of the disease and reduces the need for NSAIDs.
Kinetic ability
How are the active substances “Arthra MSM Forte 60” absorbed? The bioavailability of glucosamine when taken orally is 25%. In the human body in the highest concentration, this substance is found in the kidneys, cartilages of the joints and liver.
About 1/3 of the dose taken remains in the bone tissue and muscles for a very long time. Moreover, most of the substance of this element is excreted by the kidneys unchanged, and the remainder is excreted together with feces. The half-elimination time of glucosamine is 68 hours.
After oral administration of 800 mg of chondroitin sulfate, its plasma concentration increases sharply throughout the day. Moreover, the absolute bioavailability indicator is 12%.
About 1/10 of the dose taken is absorbed in the form of high molecular weight derivatives, and approximately 20% in the form of low molecular weight metabolites.
This component is metabolized by desulfurization. From the patient's body, it is excreted by the kidneys. Its half-elimination time is approximately 5 hours.
Indications for the appointment of tablets
What diseases are most effective when using the Arthra MSM Forte medication? Reviews of sick people report that this drug helps well with:
- spinal osteochondrosis;
- osteoarthrosis of the peripheral joints.
Drug prescribing
What contraindications for use do Arthra MSM Forte tablets have? Experts say that this medication is not recommended for use with:
- bearing the fetus, that is, during pregnancy;
- during the period of breastfeeding;
- in children under 15 years old;
- high sensitivity to the substances of the drug.
Also, with caution, this tool is used for bleeding disorders, diabetes mellitus, bronchial asthma and intolerance to various seafood (including shrimp, shellfish).
The drug "Arthra MSM Forte": instructions for use
At what dosage should the medication in question be taken? The attached instructions say that in the first three weeks of therapy, tablets should be consumed twice a day (one each). In the following weeks and months, the frequency of use is reduced to once a day.
The medication in question is intended for the treatment of people over 15 years of age. It should be noted that the therapeutic effect and absorption of the active substance of this medicine does not depend on the time of day, or on food intake.
To achieve a sustainable therapeutic result, at least six months of therapy are required.
In addition to the main treatment, in order to improve the functional state of the musculoskeletal system, patients can be recommended capsules "Arthro-Active". The daily dosage of such a dietary supplement is 4-6 capsules.
Treatment with the agent in question is carried out in courses lasting from two weeks to a month. The optimal time interval between courses is 14 days.
Negative Actions
What side effects occur after taking Arthra MSM Forte tablets? According to experts, against the background of glucosamine use, such digestive disorders as bloating or flatulence, constipation, epigastric pain and diarrhea are very often recorded. The development of the following negative reactions is also possible:
- headaches;
- dizziness;
- peripheral edema;
- drowsiness or, conversely, insomnia;
- skin manifestations of allergies;
- pain in the legs;
- tachycardia.
It cannot be said that taking chondroitin often provokes the development of hypersensitivity reactions.
Cases of overdose and interaction with other medicines
About cases of overdose of tablets "Arthra MSM Forte" to date, nothing is known. However, experts argue that when taking a large number of tablets (more than 10 pieces), the patient may experience nausea, diarrhea, hemorrhagic rashes, and vomiting. The treatment for this condition is symptomatic (i.e. gastric lavage is required).
How does Arthra MSM Forte interact with other medicines? The agent in question increases the absorption of tetracyclines, and also reduces the effect of semisynthetic penicillins. It can not be said that this medication is compatible with NSAIDs and GCS. Moreover, against the background of its use, it is possible to enhance the action of antiplatelet agents, indirect anticoagulants and fibrinolytics.
Special information
With the development of adverse reactions from the digestive tract, it is recommended to reduce the dosage prescribed by the doctor to a minimum. If after this improvement does not occur, then you need to stop taking the medication.
It is highly undesirable to give Arthra MSM Forte tablets to children under 15 years of age due to the lack of any scientific data for this category of people.
The drug in question does not have any effect on the process of driving a car, as well as the management of other dangerous mechanisms.
Similar drugs and drug costs
How much is the medication we are considering? Its price in the Russian Federation is approximately 750 rubles per 30 tablets.
If the effectiveness of this drug does not suit you, then you can replace it with one of the following analogues: KONDRONova, Teraflex, Tazan, Chondroflex, Adgelon, Chondrogluxide, Alflutop, Gamma Plant , Biartrin, Diskus Compositum, Traumeel S, Sinovial, Rumalaya, SINOART, Target T, Chondrotek Forte.
Reviews
Reviews of patients about the drug in question are controversial. Some patients claim that within three months after the start of taking this medication, they felt a significant improvement, while other people say that in the first days of treatment they faced the development of unpleasant side effects and did not see the results of therapy at all.
According to experts, the peculiarity of this medication is that it contains active substances, which are the natural structural components of cartilage tissue and intraarticular fluid. Thus, the effect of the use of this medication is directly related to filling the deficiency of these compounds in the human body. It should be noted that most doctors are not very happy with the results of using the drug in question. They claim that this medication cannot be used as the main drug. It is permissible to use it only for adjuvant therapy, together with other more effective means.