In this article, instructions for use will be presented to the preparation "Tsiprolet 500".
Most diseases are known to occur against the background of the active reproduction of pathogenic bacteria. In the treatment of such diseases, antibacterial and antimicrobial agents are often used today. "Tsiprolet" is very popular, it is often prescribed to fight infections of various origins. Quite often, patients have a question about whether the medication belongs to the category of antibiotics. This question arises due to the fact that in different sources the drug belongs to different groups. What does the instruction for use with Tsiprolet inform us?
Description
It is quite difficult to unequivocally answer the question of whether he is an antibiotic. Disputes about him as one of a group of drugs are still ongoing. Ciprolet is a fluoroquinolone whose action is to destroy the DNA of a harmful microorganism and its further death. Fluoroquinolones are active both against those bacteria that begin to multiply actively, and those that are at rest.
According to the instructions for use with Ciprolet tablets, the spectrum of action of the active substances of the drug covers both gram-positive and gram-negative bacteria, which allows the drug to be used for various diseases of an infectious nature. This is the main similarity between fluoroquinolones and antibiotics.
These groups of substances differ in origin and chemical structure. Antibiotics are substances of natural origin or synthesized analogues, while fluoroquinolones do not have similar natural substances.
Thus, it is an artificially produced antibacterial drug.
The properties
As indicated by the instructions for use with Ciprolet (500 mg), the active component is ciprofloxacin, which is included in the category of fluoroquinolones. This substance has the following properties:
- Adverse effects on various types of microbes.
- Easy penetration into tissues and cells in the human body.
- Lack of addiction of pathogenic bacteria even with prolonged use.
- Lack of quantitative or qualitative harm to the intestinal or vaginal microflora.
These are the basic properties inherent to Tsiprolet. When the active substance penetrates the bacterial cell, it stops the production of enzymes that are involved in the process of reproduction of infectious agents, which ultimately leads to the death of microbes.
In accordance with the instructions for use, "Tsiprolet" has a wide spectrum of action, so it is prescribed for the treatment of a variety of diseases. Only a limited number of bacteria can show resistance to its active substance. In most cases, “Ciprolet” is prescribed at the initial stage of the disease or if other drugs did not give the expected therapeutic effect.
Today there are four generations of fluoroquinolones, and Ciprolet is included in the group of the second of them. It with a pronounced effect fights against pathogenic bacteria, namely staphylococci, Escherichia coli, streptococci, etc. The drug is fairly quickly and well absorbed in the intestine, then entering the bloodstream, then spreading to tissues, bones and organs.
The drug is excreted mainly with urine, and the remainder with bile and feces. The price of the drug is affordable, and it is quite effective, therefore it is often prescribed by patients on their own. However, this is the wrong decision, since the causative agent of the infection may be resistant to the active substance of Ciprolet. In addition, the drug has a number of contraindications, so some groups of patients can not take it.
Indications
According to the instructions for use, "Tsiprolet" is intended for the treatment of infectious diseases of various origins, which are provoked by bacteria sensitive to ciprofloxacin. The drug is prescribed in the following cases:
- Treatment of acute respiratory infections such as an abscess, chronic bronchitis, empyema, pneumonia, infectious pleurisy, etc.
- Therapy of kidney and bladder diseases of an inflammatory nature. Even small doses of Ciprolet can eliminate cystitis and relieve inflammation in the kidneys.
- Gynecological and urological infectious pathologies, including sexually transmitted infections.
- The drug makes it possible to conduct effective treatment in the field of surgery. It is widely used in the treatment of carbuncles, abscesses, boils, mastitis and other diseases of the soft tissues and skin of an infectious origin.
- Infections of ENT organs (as an antibiotic).
- Inflammatory processes in the peritoneum, including abscess and peritonitis.
- Infectious pathologies of the joints and bones, such as purulent arthritis, osteomyelitis in chronic or acute form.
- Eye diseases caused by infection, such as conjunctivitis, keratitis, blepharitis, etc.
In the latter case, the drug is used in the form of drops. After surgery, the drug is prescribed as a prophylaxis in order to avoid the formation of a purulent infection. This is confirmed by the instructions for use with Tsiprolet.
Contraindications
Like any other drug, it has a number of contraindications, namely:
- Pregnancy and the lactation period.
- Children under 18 years of age, due to the fact that a child at this age actively forms a skeleton. For children after 15 years of age, the drug can be prescribed as a last resort and under the supervision of a specialist.
If a patient has a violation in the circulatory system, epilepsy, mental disorders, cerebral arteriosclerosis, then “Ciprolet” is prescribed only by the results of a thorough examination. Also, the administration of the drug to patients with a history of liver and kidney diseases is undesirable.
Side effects
According to the instructions for use and reviews of “Ciprolet” (500 mg), the list of side effects of the infusion solution and tablets includes the following conditions:
- Central nervous system: dizziness, headache, tremor, sleep disturbance, fatigue, anxiety, sweating, nightmares, increased intracranial pressure, hallucinations, depression, peripheral paralysis, psychotic reactions with the risk of self-harm, migraine, fainting, thrombus cerebral arteries.
- Digestive system: nausea and vomiting, abdominal pain, anorexia, flatulence, hepatitis, cholestatic jaundice, increased activity of liver and alkaline phosphatase enzymes, hepatonecrosis.
- Sense organs: violation of color perception, smell and taste, hearing loss, diplopia, tinnitus.
- Hematopoietic system: leukopenia, anemia, thrombocytopenia, granulocytopenia, hemolytic anemia, leukocytosis, thrombocytosis.
- Cardiovascular system: heart rhythm disturbance, lowering blood pressure, flushing of the face, tachycardia.
- The system of bones and muscles: arthralgia, arthritis, myalgia, tendovaginitis, tendon ruptures.
- Urinary system: hematuria, urinary retention, urethral bleeding, dysuria, polyuria, decreased nitrogen excretory function of the kidneys, interstitial nephritis.
- Laboratory research indicators: elevated levels of bilirubin, platelets, creatine and a high hypoglycemic index.
- Allergic reactions: dyspnea, urticaria, itching, swelling of the larynx and face, eosinophilia, fever, vasculitis, petechiae, erythema nodosum, increased sensitivity to light, Stevens-Johnson syndrome, Lyell syndrome, exudative erythema multiforme, the occurrence of blisters, followed by bleeding from small knots.
- Other adverse reactions: weakness, superinfection, such as candidiasis, pseudomembranous colitis, etc.
When using the solution, local reactions may occur, manifested by burning and pain at the injection site, as well as phlebitis. As indicated in the instructions for use of Ciprolet, eye drops also have a number of possible adverse reactions:
- Organs: itching and burning, slight pain, conjunctival hyperemia, swelling of the eyelids, tearing, decreased visual acuity, foreign body sensation in the eyes, keratitis, corneal infiltration, the appearance of a white crystalline precipitate.
- Other reactions: allergy, itching, sensation of an unpleasant aftertaste in the mouth after using drops, superinfection rarely develops.
Forms of the drug and dosage
The medication is available in three forms: tablets, injection, and eye drops.
Tablets "Tsiprolet" according to the instructions for use are prescribed for diseases of mild to moderate severity. They are recommended for acute bronchitis, urethritis, cystitis, genital infections and prostatitis. In addition, the drug in tablets is prescribed for tracheitis, lesions of the larynx and sinusitis. Also, this drug is indicated for acute arthrosis and rheumatoid arthritis.
This is confirmed by the instructions for use with the Tsiprolet tablets. We will consider reviews below.
It is also recommended to use tablets as a medicine for dysentery, typhoid fever, salmonellosis, as well as for chronic cholecystitis, cholangitis and duodenitis in acute form. Also, the drug is used in the treatment of periodontitis and complicated caries.
The dosage regimen is established taking into account the type of infectious disease, the course of the disease, weight and general condition of the patient. When it comes to infectious diseases of the kidneys, respiratory or urinary tracts with moderate severity, 250 mg is prescribed twice a day. In severe cases of the disease, the dose doubles.
When gonorrhea is prescribed from 250 to 500 mg once a day. Enteritis, colitis and gynecological diseases, accompanied by fever, will require taking 500 mg of Ciprolet per day according to the instructions for use.
Tablets should be taken immediately before meals, drinking plenty of water. The duration of therapy is calculated taking into account the severity of the disease. After eliminating all symptoms, the drug should be taken for another two days. Most often, the therapeutic course is from a week to ten days.
The form of the drug in the form of a solution is used in more severe cases. As a rule, these are abdominal abscesses, adnexitis, sepsis, glomerulonephritis, pyelonephritis, infectious diseases of the upper respiratory tract. All these pathologies occur in severe form. Injection should be carried out only in stationary conditions. The dosage is prescribed by a doctor who calculates it taking into account the age, weight and nature of the disease, as well as possible complications.
According to the instructions for use on Ciprolet drops, they are prescribed for infectious and inflammatory diseases of the organs of vision. These are keratitis, conjunctivitis, blepharitis, etc., also drops can be used as a prophylactic after surgery on the eyes. The drug helps prevent the development of a secondary infection if it enters the eye of a foreign body or injury. Treatment is selected depending on the severity of inflammation.
With moderate severity, it is recommended to instill two drops in each eye every four hours. In more severe cases, eye instillation every hour may be required. The duration of such therapy is from four days to two weeks.
Interaction with other drugs
As stated in the instructions for use, “Tsiprolet” (500 mg), while taking it, can interact with the following substances:
- Didanosine reduces the effectiveness of ciprofloxacin.
- Theophylline accumulates in blood plasma and increases the risk of intoxication.
- Absorption of ciprofloxacin can be reduced while taking with drugs that include aluminum, magnesium and iron ions, as well as antacids. There should be a break of at least four hours between such drugs and Ciprolet.
- Cyclosporin in combination with Cyprolet enhances its toxic effect on the kidneys.
- Similar antimicrobial drugs enhance their effect. These are drugs such as beta-lactams, metronidazole, aminoglycosides, etc.
- Nonsteroidal anti-inflammatory drugs, with the exception of acetylsalicylic acid, increase the risk of convulsive syndrome.
- Plasma ciprofloxacin absorption is increased while taking metoclopramide.
- Indirect anticoagulants prolong the bleeding period and increase their effect.
The following substances are acceptable for combination with ciprofloxacin:
- Infectious diseases caused by pseudomonads - ceftazidime, azlocillin.
- Streptococci - azlocillin, meslocillin and other beta-lactam drugs from the category of antibiotics.
- Staphylococci - vancomycin, isoxazolylpenicillins.
- Anaerobic infections - clindamycin, metronidazole.
Quite often, the question arises about the compatibility of Ciprolet with alcohol. It should be noted that alcohol itself is already a toxic substance, especially when it comes to large doses. Such abuse can lead to serious consequences for the body as a whole and the liver in particular.
In the instructions for use with Ciprolet tablets (500 mg), hepatitis is indicated among the side effects. This is due to the hepatotoxic effect that the drug may have. Accordingly, the use of alcohol during the period of treatment with an antimicrobial drug can enhance this side reaction. Thus, alcohol and this drug are absolutely incompatible, and consuming them at the same time is dangerous to health.
With this combination, the liver will suffer in the first place, and behind it, which is natural, all systems and organs will fail. In addition, the effectiveness of the drug is significantly reduced in combination with alcohol. In this case, pathogenic microbes are not completely destroyed and a relapse of an infectious disease is possible.
What else does the instructions for use with Ciprolet 500 mg tablets tell us?
There is another reason why you should not mix the product and alcohol. It lies in the fact that this combination affects the psychomotor reactions of a person, reduces coordination and concentration, and the nervous system is inhibited, which in especially severe cases can lead to a coma.
Analogs
Ciprolet is not always found in pharmacies. However, the pharmaceutical market is ready to offer several similar drugs that have a similar effect on the human body. So, for example, a fairly common option for replacing Cyprolet is Medociprin. It contains the same active substance ciprofloxacin. The drug has a very wide spectrum of action against various microbes.
"Medociprin" is prescribed for the treatment of inflammatory processes caused by infection of the respiratory tract, skin, abdominal cavity, joints, bones, urinary tract, etc. "Medociprin" is prescribed in the postoperative period as a prophylactic. In addition, the drug is used in the field of dentistry. "Medociprine" is contraindicated in children under 15 years of age, women during gestation and lactation. In some cases, individual intolerance to the components of the drug may be observed. This is stated in the instructions for use.
Eye drops "Tsiprolet" also have analogues. The most common of them is the anti-bacterial drug Tsiprodoks. This drug is prescribed for the treatment of diseases of the anterior chamber of the eye of an infectious nature. "Tsiprodoks" is contraindicated for keratitis of viral origin, as well as under the age of 15 years. This is due to the fact that at this age the active stage of skeleton formation occurs. Also, the drug is contraindicated in women during pregnancy and lactation. “Ciprodox” may affect the development of the bone structure of the fetus or newborn.
Other analogs of Cyprolet in tablets are:
- "Ciprofloxacin."
- Ciprinol.
- "Digital".
- "Tsiprobay."
There are also similar drugs for injection:
- Quintor.
- "Tsiprobid".
- Ififpro.
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Reviews
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conclusions
Ciprolet is a powerful and potent drug, it can cause the development of various side effects. For this reason, you should not appoint it yourself. This drug should be prescribed by a doctor based on the results of a patient examination. The most common adverse reactions to taking Ciprolet are nausea, diarrhea, and headache. Properly selected dosage by a specialist will help to avoid complications and achieve maximum therapeutic effect.
We reviewed the instructions for use with the Tsiprolet 500 mg tablets, eye drops and solution.