The drug is active against a large number of gram-positive and gram-negative bacteria, and also has a bactericidal effect. "Augmentin" is a complex drug of a wide spectrum of action, the composition includes the following active substances:
- amoxicillin;
- clavulanic acid.
The drug effectively fights diseases of the respiratory tract, organs of the urinary system and the gastrointestinal tract. Thanks to the combined composition, Augmentin slows down the development of antibacterial resistance by harmful microbes.
Clavulanic acid protects amoxicillin from the damaging effects on beta-lactamases, which are produced by microorganisms that are highly resistant to the penicillin group of drugs and cephalosporins. The medicine quickly eliminates inflammation and prevents the infection from spreading to neighboring organs and tissues. As a rule, at the first manifestations of pharyngitis and tonsillitis, doctors prescribe Augmentin, which makes recovery quicker.
Release form
According to the instructions and reviews, Augmentin is available in the following forms:
- powder for suspension, in a dosage of 125 milligrams of amoxicillin to 34.5 milligrams of clavulanic acid in five milliliters of the finished medicine;
- powder for the manufacture of an oral suspension, at a dose of 200 milligrams of amoxicillin per 28.5 milligrams of clavulanic acid in five milliliters of the finished solution;
- a powder that contains 400 milligrams of amoxicillin and 57 milligrams of clavulanic acid to prepare five milliliters of a suspension;
- powder for the manufacture of a solution for intravenous administration;
- EU powder intended for the preparation of a children's suspension (contains 600 milligrams of amoxicillin per 42.9 milligrams of clavulanic acid);
- 500 tablets per 125 milligrams;
- Augmentin tablets 875/125 milligrams;
- 250 tablets per 125 milligrams.
Indications
According to reviews and instructions, "Augmentin" 875/125 is used in the treatment of the following ailments and diseases:
- Otitis (a disease that is an inflammatory process in the ear).
- Tonsillitis (inflammation in the tonsils, which occurs due to the action of bacteria or viruses on the lymphoid tissue).
- Pharyngitis (acute or chronic inflammatory process localized in the pharynx, affecting its mucous membrane and deeper layers).
- Sinusitis (inflammation of the mucous membrane of one or more sinuses).
- Acute bronchitis (a disease of the respiratory system in which the bronchi are involved in the inflammatory process).
- Pneumonia (pneumonia - inflammation of the lung tissue, usually of an infectious origin with a primary lesion of the alveoli).
- Cystitis (An inflammatory disease of the mucous membrane of the bladder, manifested by frequent and painful urges to urinate).
- Pyelonephritis (inflammation of the kidneys, which occurs in acute or chronic form).
- Urethritis (inflammation of the urethra caused by damage to the walls of the canal of various bacteria and viruses).
- Bacterial vulvovaginitis (inflammatory diseases that affect the sheath of the vagina, as well as the labia).
- Endocervicitis (inflammation of the mucous membrane of the cervical canal caused by opportunistic microflora or pathogens of sexually transmitted infections).
- Infections of the skin and soft tissues.
- Dysentery (an infectious disease characterized by general infectious intoxication syndrome and gastrointestinal tract syndrome, mainly the distal colon).
- Salmonellosis (acute intestinal infection of animals and humans caused by salmonella).
- Osteomyelitis (an infectious inflammatory disease in which not only bone and bone marrow are affected, but the whole body as a whole).
- Infectious arthritis (an inflammatory process in the joints caused by the penetration of infectious pathogens into the body).
- Periodontitis (a disease that affects the connective tissue located between the bone of the socket and cement of the root of the tooth).
- Dental abscess (accumulation of pus that forms in a diseased tooth and can spread to neighboring tissues).
- Gonorrhea (an infectious disease transmitted mainly through sexual contact).
- Sepsis (a serious infectious disease that develops with progression, and the spread of the infectious process through the body through the blood).
And also the drug is prescribed in the postoperative period (with infectious complications).
Instructions for use
Reviews about “Augmentin” (tablets) indicate that for optimal absorption of nutrients and reduce side effects from the gastrointestinal tract, the drug is recommended to be taken before meals. The minimum course of antimicrobial therapy is five days. The duration of treatment should not be more than fourteen days.
- Adult patients with an infection of mild or moderate severity should take one tablet of 250 per 125 milligrams three times a day, or one tablet of 500 per 125 milligrams three times a day, or one capsule at a dosage of 875/125 milligrams three times per day.
- And you can also take one Augmentin tablet 875/125 milligrams twice a day, or 11 milliliters of a suspension of 400/57 milligrams twice a day.
According to the instructions for use and reviews of "Augmentin" 875/125, the duration of the medication is set by the doctor depending on the weight, age, severity of the disease.
Can I take Augmentin for lactation?
Like most antibacterial microelements, amoxicillin, getting into the body is distributed throughout all tissues, while it also penetrates into breast milk. The medicine belongs to the group of approved medications for lactation.
Can I take the drug for children?
A child over twelve years of age is prescribed the same dosages as an adult patient.
- For children from three months to twelve years of age (weight not less than 40 kilograms), the drug is prescribed in the form of a suspension for oral administration. Calculation of the dose of the drug depends on age, body weight.
- For babies from birth to three months, the recommended dose is 30 milligrams per kilogram in two divided doses in the form of a suspension, as indicated in the instructions and reviews.
"Augmentin" for children should be taken only after consulting a doctor. It must be remembered that two tablets of 250/125 milligrams are not equal to one capsule in 500/125 milligrams.
Contraindications
Like any other drug, Augmentin has certain prohibitions. For example, a drug cannot be taken with the following ailments:
- hypersensitivity to penicillin, cephalosporin;
- infectious mononucleosis;
- pregnancy
- breastfeeding.
As well, the drug is prescribed with caution in case of serious liver disorders. If there are signs of erythematous rash, urticaria, it is recommended to stop treatment. According to reviews, Augmentin (125 milligrams of clavulanic acid) is not recommended for use with Probenecid and Allopurinol.
Side effects
The drug "Augmentin" has some undesirable body reactions to the drug, for example:
- Headache.
- Dizziness.
- Cramps.
- General excitement.
- Behavior change.
- Insomnia.
- Interstitial nephritis.
- Hematuria
- Diarrhea.
- Nausea.
- Vomiting
- Gastritis (a long-running disease, characterized by dystrophic and inflammatory changes in the gastric mucosa).
- Colitis (an inflammatory disease of the colon mucosa).
- Stomatitis (damage to the oral mucosa).
- Black coating on the tongue.
- Discoloration of tooth enamel.
- Hepatitis (inflammatory liver disease, usually of viral origin).
- Cholestasis (stagnation of bile).
- Jaundice (icteric staining of the skin and visible mucous membranes, due to the increased content of bilirubin in the blood and tissues).
- Increased bilirubin levels.
- Plasma transaminases and alkaline phosphatases.
- Allergic rash.
- Itching
- Erythema (abnormal redness of the skin, which develops if the blood rushes to the capillaries in excess).
- Dermatitis (an inflammatory lesion of the skin resulting from exposure to damaging factors of a chemical, physical or biological nature).
- Toxic epidermal necrolysis (severe allergic pathology, the result of which is the exfoliation of the upper layer of the skin).
- Candidiasis infection (a disease caused by candida fungi).
- Anaphylactic reactions (clinical manifestation of an immediate systemic allergic reaction).
- Hemorrhagic vasculitis (consists of aseptic inflammation of the walls of microvessels).
- Angioedema (a reaction to the effects of various biological and chemical factors, often of an allergic nature).
- Anemia (a decrease in the concentration of hemoglobin in the blood, more often with a simultaneous decrease in the number of red blood cells).
- Eosinophilia (a condition in which there is an absolute or relative increase in the number of eosinophils).
- Leukopenia (a decrease in the number of leukocytes per unit volume of blood).
- Agranulocytosis (a serious blood disease associated with a significant decrease in cells from the group of leukocytes).
- Thrombocytosis (increased platelet count in the blood).
- Slowing down blood coagulation.
Overdose
When taking excessively high dosages of the drug, problems with the gastrointestinal tract and disturbances in the water-electrolyte balance can be observed. Therapy is symptomatic, correction of water-electrolyte failures is carried out. And also with an overdose, excess salts may occur in the body, which for various reasons are not excreted naturally.
Russian-made substitutes
“Augmentin” has analogues both in active substance and in spectrum of action:
- Amosin.
- Amoxicillin Ecobol.
- "Ecoclave".
- "Arlet."
- "Verklav".
Amosin is a broad-spectrum antibacterial drug of the penicillin group. The drug is available in the form of tablets (ten pieces per pack) of 250 and 500 milligrams. The main component of the medication, like Augmentin, is amoxicillin. The medicine is not recommended for use in combination therapy with Metronidazole. The price of the drug "Amosin" 250 milligrams is 30 rubles, and for tablets with a dosage of 500 milligrams - 60 rubles.
Amoxicillin Ecobol is a broad-spectrum antibacterial agent from the group of synthetic penicillins. Penetrating into the body, the antibiotic contributes to the violation of the fibrillar protein in the affected tissues. Indications for use are the following diseases:
- Dermatosis
- Typhoid fever.
- Dysentery.
- Salmonellosis.
- Gonorrhea.
- Bronchitis.
- Otitis.
The medicine is available in the form of tablets, which are packaged in blisters of twenty pieces.
One capsule of Amoxicillin Ecobol contains 500 milligrams of the active substance. Auxiliary components are:
- lactose;
- povidone;
- starch;
- talc;
- magnesium;
- sodium;
- crospovidone.
The action of the drug is aimed at eliminating bacterial cells. Amoxicillin Ecobol is active against streptococci and staphylococci. The antibiotic is taken orally thirty minutes before a meal. Both adults and children are prescribed 500 milligrams three times a day. The duration of therapy is at least ten days. Children from five to ten years old must take 500 milligrams twice a day. The duration of treatment is from five to seven days. The price of the drug is from 100 to 180 rubles.
"Ecoclave" is a combined bactericidal drug that has an effective effect on many diseases caused by gram-negative and gram-positive anaerobes. The medicine is available in the following forms:
Five milliliters of the finished suspension contains:
- amoxicillin - 125 or 250 milligrams;
- clavulanic acid - 125 milligrams.
Excipients are the following trace elements:
- aspartame;
- lactulose;
- xanthan gum;
- colloidal silicon dioxide (aerosil);
- anhydrous citric acid;
- sodium benzoate;
- crospovidone;
- mannitol;
- sodium citrate dihydrate;
- orange flavoring;
- talc.
One tablet contains:
- amoxicillin - 250, 500 and 875 milligrams;
- clavulanic acid - 125 milligrams.
Additional substances that make up the drug:
- roscarmellose sodium;
- lactulose;
- crospovidone;
- ascorbic acid;
- microcrystalline cellulose;
- talc;
- magnesium stearate;
- ethyl cellulose;
- hypromellose;
- diethyl phthalate.
Active trace elements in therapeutic doses enter the tissue fluid and a large number of organs. The drug effectively copes with infectious and inflammatory diseases that are caused by pathogens sensitive to the combination of active components. The cost of the drug varies from 170 to 300 rubles, depending on the form of release.
"Arlet" is an antibacterial drug, available in tablets (in jars or cardboard packaging). The active substances are the same trace elements as that of Augmentin.
The drug is taken orally with a sufficient amount of water. Do not chew and share tablets. The treatment regimen is prescribed by the attending physician; therapy is established strictly individually, taking into account age, weight, and kidney and liver function. As a rule, the duration of the course is not more than fourteen days. The cost of an antibiotic is 400 rubles.
Foreign generics
Augmentin, like any other antibiotic, is dispensed in pharmacies only with a prescription. But this does not prevent it from acquiring its analogue if the medicine is not available or its price does not suit.
- Amoxiclav.
- "Amoxicillin DS".
- "Panklav."
- "Klava".
Amoxiclav is a Swiss drug that contains the same active trace elements as Augmentin. The cost of the drug varies from 200 to 450 rubles.
“Panklav” is a Serbian antibacterial agent, widely used in gynecology, as well as in the treatment of bacterial lesions of bones and joints. The price of the drug is 400 rubles.
“Clavam” is an Indian drug that has antibacterial effect in the treatment of many diseases and ailments. The drug is dispensed in suspension, its price is 170 rubles.
"Amoxicillin DS" is a Vietnamese antimicrobial medication that has a wide spectrum of action against many diseases:
- tonsillitis;
- pneumonia;
- bronchitis;
- urethritis.
The cost of the drug is 100 rubles.
Cost of Augmentin
The price of the drug varies depending on the form and amount of active substances in the composition of the drug:
- powder 200 / 28.5 milligrams - 150 rubles;
- powder 400 / 42.9 milligrams - 250 rubles;
- powder 600/57 milligrams - 430 rubles;
- Augmentin tablets 250/125 milligrams - 250 rubles;
- Augmentin tablets 500/125 milligrams - 350 rubles;
- Augmentin tablets 875/125 milligrams - 340 rubles.
This is an approximate cost, check it in the pharmacies of your city.