Acne spares no one and affects the skin of both girls and boys, as well as people of a more mature age. To remove them, they use different drugs, including Klenzit S. From acne, reviews indicate this, the drug cures effectively, but the result appears only after prolonged use.
The composition of the drug
Active substances are:
- adapalene, which is a retinoid, that is, a synthetic analogue of retinoic acid, 1 mg per gram of Klenzit C gel for acne;
- clindamycin in a ratio of 10 mg per 1 gram of the drug.
Auxiliary components:
- propylene glycol;
- disodium edetate;
- carbomer 940;
- sodium hydroxide;
- purified water;
- methyl parahydroxybenzoate;
- phenoxyethanol;
- poloxamer 407.
The medicine is intended for external use only, packaged in tubes of 15 and 30 grams. The manufacturer is the corporation Glenmark Pharmaceuticals Ltd (India).
The active substance is adaptal and is present in a number of similar drugs aimed at eliminating acne, this:
- "Klenzit";
- "Differin";
- “Adapalen”;
- "Adolen-gel";
- Adaklin.
The drug is characterized by anti-inflammatory, anti-comedogenic, bacteriostatic properties. Often used not only for resorption of deep acne, comedones, but also to eliminate inflammatory processes. The skin after its application is cleansed, closed and open acne disappear, metabolic processes in the skin layers and cell regeneration pass faster. It is often recommended for treating juvenile acne.
Pharmacodynamics
Acne Remedy “Klenzit” refers to combination preparations, where adapalene and clindamycin act as active substances.
Adapalene as a retinoid derivative acts on the skin as an anti-inflammatory and comedonolytic agent. Affects both open and closed comedones. Restores epidermal differentiation and keratinization. Slows down the binding of follicular particles of the epidermis, which prevents the occurrence of acne. Significantly slows down the chemokinetic reactions of the dermis and chemotaxis of polynuclear cells of the skin.
Clindamycin contained in the preparation “Klenzit C” for acne, the instruction refers to lincosamides. It is a semi-synthetic antibiotic. Its bacteriostatic activity against a number of microorganisms is observed, for example, such as coccal and anaerobic. It has a connection with the 50S subunit of ribosomal membranes, significantly reduces protein replication in the pathogenic cell. It is characterized by a bactericidal orientation to certain types of gram-positive cocci.
Adapalene in combination with clindamycin increases the effectiveness of the drug and better eliminates inflamed skin. Tests have shown the unique compatibility of these two substances.
Absorption of the drug in the tissues of the body with local use is negligible.
Klenzit ointment for acne, as shown by practice, effectively removes acne and prevents the formation of new comedones. Smoothes the surface of the skin, improves its appearance.
The action of Klenzit S against acne
The reviews suggest that the effective effect of this product on the skin is based on the qualitative components of retinol, in connection with which:
- the release of fat on the surface of the epidermis is reduced by reducing the secretion of sebaceous glands; this process does not allow the skin ducts to become clogged and prevents the occurrence of comedones;
- the percentage of propionic acne microbes is reduced by reducing sebum in the dermis;
- fat plugs dissolve in the pores, as a result of which the skin is cleansed;
- the process of formation of new dead cells is restored, which prevents the emergence of new particles in large numbers in the layers of the epidermis, therefore, the pores are less clogged and comedones do not multiply;
- the drug is an excellent antiseptic and quickly removes the inflammatory process;
- the protective functions of the skin are restored, the sebum-fat metabolism in the cells improves.
Indications and contraindications
The gel is indicated for external use in case of acne of various manifestations and forms of severity.
Contraindication to the use of the gel is intolerance to adapalene and other components in the composition of the drug, as well as hypervitaminosis A and combined administration with other drugs, which include retinol. A ban is also a violation of the integrity of the skin, that is, the presence of wounds, burns and other injuries on the skin. You can not use it during pregnancy and lactation, despite the fact that only 4% of the drug is absorbed in the body, and subsequently excreted by bile. In this case, Klenzit S, like any other antibiotic, can negatively affect the development of the fetus.
With caution, it should be used with agents that cause excessive dryness of the epidermis, as well as with eczema and dermatitis. After applying the Klenzit S gel for acne, the reviews of which are simply excellent, you can’t visit the tanning bed one day before the application and within one day after.
Side effects of the drug
In some cases, the occurrence of side effects due to the use of the drug "Klenzit". Acne gel, the reviews of which are the most positive, can provoke severe dryness of the skin, as well as cause itching, burning, hyperemia, irritation and redness. In the event of a similar situation, you should temporarily suspend the use of the drug and continue the therapeutic course after the complete disappearance of side effects.
Peeling often appears. It occurs as a result of the effect of retinoids on the skin. In this case, it is recommended that after 30 minutes after applying the drug, lubricate the surface of the skin with a moisturizer.
Sometimes there is an exacerbation of acne, which passes during the treatment. Cases of allergy to the drug and individual intolerance to the drug were noted, but similar situations were rarely observed.
"Klenzit C" for acne: instructions for use
The drug is intended exclusively for external use. The drug is applied only to acne and is not rubbed. Ointment is not used on skin that has damage, abrasions, scratches or burns. At the beginning of treatment, the gel may cause a more active acne. But do not stop the therapy, since the process of deep cleansing of the dermis takes place, at this time the Klenzit drug pushes everything unnecessary from the pores to the surface of the skin, therefore, acne appears more actively.
The agent is applied to the inflamed area and dotted 1-2 times a day. If the application is reduced to once, then it is recommended to apply "Klenzit" immediately before bedtime. Acne gel, which reviews are impressive, should be applied on the skin surface thoroughly cleaned of dirt and dust. If the use of the drug occurs in the daytime, then for two hours after applying the ointment, you should not wash your face and apply cosmetics. The course of treatment and the pattern of use of the drug is prescribed and monitored by a cosmetologist. On average, the therapeutic period lasts from 4 to 8 weeks. If necessary, the period is extended, but not more than 3-4 weeks.
The drug can be addictive, as a result of which the bacteria become less sensitive to its effects, therefore, if the acne does not disappear after the specified time, the treatment should be continued with other drugs.
Features of using the gel
"Klenzit" for acne is a medicine, and therefore it should be used with caution and only after consulting a doctor. Also, during its use, you should adhere to certain recommendations:
- try to apply the gel directly to the affected area without touching healthy skin;
- carefully monitor that the product does not get into the eyes and on the mucous membranes of the nasal and oral cavity;
- you can not apply the drug to an injured skin that has abrasions, burns, scratches;
- Be sure to wash your hands after applying the drug;
- in case of excessive dryness of the dermis, Pantenol or Bepanten preparations should be used;
- Do not use Klenzit S in sunny hot weather, because during this period the skin is especially defenseless and is exposed to aggressive ultraviolet rays;
- when peeling the skin, you should use any moisturizing face cream;
- do not use the ointment in case of irritation, with severe redness or allergic reactions.
Overdose and interaction with other medicines
Local use of the drug almost completely eliminates overdose. In case of accidental ingestion of the gel inside, experts recommend immediately rinsing the stomach and drinking enterosorbents.
“Klenzit S” should not be combined with alcohol-containing (ethanol-containing) products, such as lotions, colognes, eau de toilette. Also, for the treatment period, it is worth abandoning creams that have a drying, irritating effect. Do not use drugs during this period, which include calcium gluconate, aminoglycosides, ampicillin, magnesium sulfate and a vitamin B complex.
Often the gel is used in combination therapy with agents containing benzoyl peroxide. Usually, only Clenzin C is prescribed for one or two weeks, and then a skin-friendly treatment is prescribed. For example, in the morning “Baziron AS” (the active substance is benzoyl peroxide), and in the evening “Klenzit” containing only retinoid, without the addition of the antibiotic clindamycin.
When using the drug "Klenzit C" simultaneously with erythromycin, the effectiveness of the first is significantly reduced.
What to prefer: "Klenzit" or "Klenzit S"
The preparations “Klenzit” and “Klenzit S”, despite the similar name, radically differ in their effect. The first contains one active substance - adaptale. It is often used for minor inflammatory processes on the face, enlarged pores, and small acne. The tool has an excellent comedonolytic property.
“Klenzit C” contains in its composition not only adaptal, but also the antibiotic clindamycin in a proportion of 10 ml per 1 gram of gel. Therefore, it is often used for severe pustular inflammation on the face, when one component of the retinoid can not cope.
Which remedy for acne treatment to choose is an individual question. In any case, before using this or that drug, it is better to consult a specialist. After all, only then can you be sure of the correctness of the chosen solution.
“Klenzit S” and “Klenzit” for acne can be purchased at a regular pharmacy or online resources. The cost of the drug varies depending on the place of sale and starts from 350 rubles per tube in 15 ml.
The drug is dispensed only by prescription. The drug should be stored in a dark, cool place inaccessible to children, at a temperature not exceeding 25 ° C.
The shelf life of the drug is two years.
Reviews about the drug
Acne Remedy “Klenzit” caused a lot of conflicting reviews. For some, he became a real panacea, and within a few days the result was noticeable. Someone felt the effectiveness of the drug after 3-4 weeks of use.
These people have significantly reduced the number of acne and comedones. The skin of the face was leveled. During treatment, some people complained of excessive dryness of the skin and peeling. Someone after that completely stopped using it. Others switched to a regimen for using the drug every other day.
There is a category of women who peeling places lubricated with a moisturizing or nourishing cream. But, as a rule, peeling is observed only at the initial stage of treatment, while the skin integrates under the influence of the drug, and such phenomena are practically not observed in the future. Undoubtedly, they are evidence that the drug “Klenzit S” for acne is effective, reviews. Photos before and after its application just confirm this.
But not everyone is happy with the result of treatment. Some individuals, both at the beginning of treatment and later on, had severe redness of the skin, peeling, profuse acne eruptions and the number of comedones increased markedly. They had to stop using the drug and replace it with another drug. Allergic skin rashes have also been reported .
A certain category of citizens used Klenzit S for acne on their backs. Here the effectiveness of the drug was at its best. This area of the body is not as sensitive as the skin on the face, so almost no one had any side effects.
Women with acne can do anything to get rid of it. For these purposes, the most powerful drugs are often used, since they act quickly and effectively. But they are advised to use these drugs to treat acne with an antibiotic when other drugs did not help.
The drug, which we examined in our article, cleared more than one face from acne. Even more effective results were shown by Klenzit for acne on the back. It should also be borne in mind that spot application may not bring the desired effect, since in this case the medicine only affects acne, but should also affect the area adjacent to acne.