Pain is the first sign of an inflammatory disease. It signals any violation within the body or the action of any destructive factor from the external environment. Anesthetic drug will help to cope with the source of pain. "Pentalgin" is a combined drug with analgesic, anti-inflammatory, and also antipyretic effects.
Release form, composition
Pentalgin is available in the form of tablets (from 2 to 12 pieces in one contour package) and 5% gel (30 and 50 grams). Capsules are film-coated, oval, from pale green to green. The active components that make up the tablets are the following trace elements:
- paracetamol;
- pheniramine maleate;
- naproxen;
- drotaverine hydrochloride;
- caffeine.
Excipients are:
- tribasic carboxylic acid;
- magnesium salt of stearic acid;
- primrose;
- starch;
- talc;
- cellulose;
- ionol;
- hyprolosis;
- indigo carmine;
- quinoline yellow dye.
The composition of the film coating that covers the tablets:
- povidone;
- titanium dioxide; indigo carmine;
- hypromellose;
- quinoline dye;
- talc;
- polysorbate.
“Pentalgin. Extra-gel "is produced in the form of a translucent liquid from a yellowish to brown shade, with a characteristic aroma. It is a non-steroidal anti-inflammatory drug for external use.
One gram of gel contains:
- ketoprofen;
- chilli peppers;
- dimexide;
- camphor;
- peppermint oil;
- hypromellose;
- sodium hydroxide;
- ethanol;
- water.
The properties
The instructions to Pentalgin indicate that paracetamol, which is part of the drug, is considered a non-narcotic pain medication that has analgesic and antipyretic effects. Its action is to block the enzymes involved in the synthesis of prostanoids in the central nervous system. And also the substance acts on a mechanism that allows living organisms to maintain a constant body temperature and pain.
Pheniramine is endowed with a minor sedative and antispasmodic property. The trace element increases the analgesic effect that paracetamol and naproxen have. In addition, feniramin reduces the process of isolating fluid in tissue or body cavities from small blood vessels during inflammation.
According to the instructions for use "Pentalgin", naproxen has anti-inflammatory properties, and is also characterized by antipyretic and analgesic effects.
Drotaverin eliminates spasms of smooth muscles of the organs, cardiovascular and genitourinary systems, in the biliary tract and gastrointestinal tract.
Caffeine has an exciting effect on the vessels of the brain. In addition, it is able to expand the blood vessels of the kidneys, heart, skeletal muscles. Caffeine significantly increases the permeability of physiological "filters" that are between the blood and tissue fluid. The component increases the ability of non-narcotic analgesics to be quickly absorbed, thereby providing a fixation of the therapeutic effect. Caffeine helps increase mental and physical performance, helps to effectively combat drowsiness and fatigue.
According to the instructions for the use of Pentalgin gel (Extra), ketoprofen, when used externally, has an analgesic and decongestant effect. The trace element inhibits the activity of enzymes that regulate the metabolism of prostaglandins.
The use of extra-gel provides a local therapeutic effect against inflamed ligaments, muscles and tendons. Ketoprofen does not have the slightest destructive effect on articular cartilage.
Indications
According to the instructions for use, "Pentalgin" in tablets is prescribed in the presence of the following symptoms and diseases:
- Pain of various origins, including migraine and pain resulting from spasms of the vessels of the brain.
- Painful menstruation, accompanied by a violation of the general condition.
- Neuralgia (damage to the peripheral nerves, characterized by bouts of pain in the innervation zone of a nerve).
- Radiculitis (spinal cord lesions that cause motor, autonomic and pain disorders).
- Myalgia and arthralgia (pain in muscles and joints).
- Pain in post-cholecystectomy syndrome (functional restructuring of the biliary system after surgery).
- Toothache.
- Pain in gallstone disease (a disease characterized by the formation of gallstones or bile duct stones).
- Pain in chronic inflammation of the gallbladder.
- Renal colic (sharp pain in the lower back, which is caused by a violation of the outflow of urine from the kidney).
- Postoperative and post-traumatic pain.
- Acute respiratory illness with fever.
According to the instructions "Pentalgin. Extra-gel "is recommended for use in the presence of the following ailments:
- Tendonitis (an inflammatory lesion of the ligaments and tendons).
- Osteoarthrosis (a disease in which joints undergo degenerative-dystrophic damage).
- Osteochondrosis with radicular syndrome (a chronic disease that affects the cartilage of the intervertebral discs).
- Radiculitis.
- Bursitis (an inflammatory disease of the synovial bag characterized by excessive formation and accumulation in its cavity).
- Sciatica (an inflammatory process that affects the sciatic nerve, sciatic nerve neuritis).
- Lumbago (acute pain in the lower back).
- Muscle pains of a rheumatic and non-rheumatic nature.
- Damage and rupture of ligaments, bruises.
The drug is intended for symptomatic treatment, reduce pain and inflammation.
Contraindications
As indicated in the instructions for use, Pentalgin has a number of limitations:
- Pregnancy.
- Disorder of all kidney functions.
- Gastrointestinal bleeding (blood flow from the blood vessels eroded or damaged by the pathological process into the lumen).
- Erosed and ulcerative lesions of the intestinal stomach.
- Hyperkalemia (a condition in which the concentration of potassium in the plasma exceeds the norm).
- Implementation of coronary artery bypass grafting (surgery on the blood vessels of the heart, which is broken by a chronic disease of arteries of elastic type, which is aimed at resuming their blood circulation by creating artificial vessels).
- An acute source of ischemic necrosis of the heart muscle, which develops as a result of an acute disturbance in coronary circulation.
- Diseases of the heart and blood vessels.
- Persistent increase in blood pressure.
- Lactation period.
- Heart rhythm disturbances, characterized by extraordinary, premature contractions of the ventricles.
- Paroxysmal tachycardia (an attack of rapid heart contractions that suddenly begin and end just as suddenly).
- The complex of symptoms, which is characterized by damage to the liver as a result of acute or chronic damage to its tissue.
- Bronchial asthma, with repeated benign formations in the nasal cavity.
- Aplastic anemia (a disease of the hematopoietic system, which belongs to the category of myelodysplasias).
- Hypersensitivity to trace elements that make up the drug.
- Benign hyperbilirubinemia (diseases associated with a hereditary disorder of bilirubin metabolism).
- Long-term benign disease, which is manifested by intermittent icteric staining of the skin with an elevated level of predominantly bilirubin.
- Rotor Syndrome (a genetically determined enzyme that causes impaired bilirubin transport in the liver).
- Gilbert's syndrome (a genetically caused disturbance in bilirubin metabolism resulting from a defect in microsomal liver enzymes).
- Viral hepatitis (acute infectious liver damage characterized by a benign course).
- Toxic liver damage with alcohol.
- Endocrine disease due to a lack of the hormone insulin in the body or its low biological activity.
- Peptic ulcer of the stomach and intestines.
- Peripheral artery disease (discomfort or pain in the legs when walking).
- Decreased glucose-6-phosphate dehydrogenase activity.
- Cerebrovascular diseases (diseases of the brain caused by pathological changes in cerebral vessels with impaired cerebral circulation).
- Epilepsy (a common disease of the nervous system characterized by periodic seizures).
- Elderly age.
- Wet dermatoses (skin disease, which is a consequence of a malfunction of the internal organs).
- Inflammation of the skin, which has a long chronic course with frequent complications.
- Infected abrasions, wounds.
- Skin allergy to sunscreens or perfumes.
- Age to eighteen.
Pentalgin tablets: instructions for use
The drug is intended for oral administration. Adults are prescribed one capsule from one to three times a day, depending on the course of the disease, age. The maximum daily dose is four tablets, the interval between doses is six hours.
As a rule, it is recommended to drink the capsule whole. To protect yourself from the damaging effects of the drug on the mucous membranes of the stomach and intestines, you need to take the pill after a meal.
According to the instructions for use, Pentalgin tablets are not recommended for more than three days, as in this case the risk of side effects increases. In rare situations, Pentalgin can be consumed for up to five days, but only under the strict supervision of a physician.
In the absence of a therapeutic effect during the first three days, the patient should consult a doctor to select another medicine.
How to apply ointment?
According to reviews and instructions for use, “Pentalgin. Extra-gel "must be used as follows:
- The gel should be used only on clean skin. A small amount of gel should be applied in a thin layer.
- Then, gently rubbing, spread the drug on the inflamed area of the skin.
- The gel is used two to three times a day.
- The duration of therapy is not more than fourteen days.
According to the instructions "Pentalgin" (gel "Extra") should be applied only to intact skin, while avoiding contact with wounds, eyes and mucous membranes. After applying the ointment, wash your hands. The formation of a thin film on the skin at the site of application of the gel is allowed.
Side effects
According to reviews and instructions, Pentalgin (tablets) has certain negative reactions after taking high dosages:
- Impaired kidney function.
- Anxiety.
- Arrhythmia.
- Gestational hypertension.
- Hearing loss.
- Ophthalmotonus.
- Insomnia.
- Nausea.
- Hyperreflexia (inflammation, which is characterized by an increase in methemoglobin).
- Decreased attention span.
- Excitation.
- Dizziness.
- Skin rash.
- Tremor (rhythmic, rapid movement of limbs).
- A decrease in blood levels of white blood cells, red blood cells, or platelets.
- An increase in the amount of methemoglobin (methemoglobinemia).
- Discomfort in the pit of stomach.
- Vomiting
- Noise in ears.
- Intestinal obstruction.
- Flatulence.
- Migraine.
- An ulcer of the stomach or intestines (a local defect in the gastric mucosa that occurs under the influence of hydrochloric acid).
- Liver dysfunction.
- A disease of allergic origin, which is fraught with the appearance of blisters on the skin.
- Dermatitis (contact acute inflammatory lesion of the skin tissue resulting from exposure to irritating factors).
- Angioneurotic edema (acute condition, which is characterized by the rapid development of local edema of the mucous membrane).
- Tachypnea (rapid surface breathing, which is not accompanied by a violation of the respiratory rhythm).
- Erythema (severe redness of the skin caused by the expansion of capillaries).
- The phenomenon of increasing the body's sensitivity to ultraviolet radiation.
Overdose
According to reviews and instructions for use with Pentalgin (gel and tablets), the symptoms of this phenomenon are diverse. These include:
- Increased prothrombin series.
- Pale skin.
- Loss of appetite.
- Anorexia (excessive thinness).
- Hepatonecrosis (a complication of many liver diseases that is associated with the elimination of cells).
- The increased activity of special liver enzymes, which play an important role in transamination processes.
- Motor anxiety (akathisia).
- Nervous excitement.
- Muscle spasms.
- Attacks that develop due to the occurrence of too strong neural discharges in the cerebral cortex.
- Confusion (confusion of a person’s consciousness, which may be short or long in nature).
- Rapid urination (nocturia).
- Hyperthermia (a pathological process characterized by an increase in body temperature, the level of which depends on the environment).
- Arrhythmia (violation of heart rhythm, as well as electrical conduction of the heart).
- Tachycardia (a special condition of the body in which the heart rate exceeds the norm).
Price
The cost of Pentalgin varies depending on the form of release:
- Gel - 200-300 rubles.
- Tablets - from 90 to 180 rubles.
Substitutes
Like any other medicine, the medicine has generics. Pentalgin analogs in tablets:
- "Plyvalgin."
- Pentalffen.
- "Sedalgin."
- Pentamialgin.
Some drugs include narcotic analgesics, so they are available in pharmacies only with a prescription.
"Sedalgin" is a non-steroidal anti-inflammatory drug, used to symptomatically reduce pain, as well as to reduce elevated body temperature. The cost of the drug is 180 rubles. The drug is produced in the form of tablets, their composition includes the following trace elements:
- caffeine;
- metamizole sodium;
- thiamine hydrochloride.
"Sedalgin" has an analgesic, anti-inflammatory therapeutic effect. Substances are evenly distributed throughout the human body, inactive decay products are excreted in the urine. The components that make up the drug are rapidly and completely absorbed from the intestine into the blood, as indicated in the instructions.
Pentalgin gel has other analogues:
- "Arthrosilen."
- "Bystrumgel."
- Valusal
- Ketonal.
- Ketoprofen.
- "Fastum."
- "Febrofid."
- "Flexen."
- "Artrum."
"Bystrumgel" - a drug for external use, has analgesic and anti-inflammatory effects. The drug is applied to the damaged area twice a day, distributing it with a uniform thin layer. Do not use the gel on open wounds. The cost of the drug varies from 200 to 500 rubles.
"Fastum" is used to reduce inflammation and pain in various diseases of the musculoskeletal system. The main active ingredient that is part of the drug is ketoprofen. After application, the gel is rapidly absorbed into the tissue, where it has an antiphlogistic effect (anti-inflammatory). Caution should be used in case of kidney and liver disorders. The cost of the drug is from 200 to 600 rubles.