How effective is the drug Metadoxil? Reviews of alcoholics, the price of this drug and its indications are discussed below. Also from this article you will learn about the method of using this medication, its side effects and contraindications.
Description, form, composition
The drug "Metadoxil" (reviews of alcoholics about it will be presented later) goes on sale in the following forms:
- Biconvex and round white tablets with a risk on one side and an engraving of the name of the drug on the other. Its active component is pyridoxine L-two pyrrolidone five-carboxylate or the so-called metadoxine. Also, the composition of this tool includes MCC and magnesium stearate.
- Transparent injection solution without color or with a yellowish tint. Its main component is also methadoxine. In addition to it, the composition of the drug includes sodium edetate, water d / and, sodium metabisulfite and methyl parahydroxybenzoate.
Drug action
"Methodoxil" is a cure for alcoholism. Also, this tool exhibits detoxification and hepatoprotective properties.
The hepatoprotective effect of this medication is due to its membrane-stabilizing effect. In addition, this drug is able to restore the ratio of free unsaturated and saturated fatty acids. As a result, the resistance of hepatocytes to the effects of fat peroxidation, which occurs when toxic agents act, is increased.
The detoxification properties of this drug are due to the activation of liver enzymes that take part in the metabolism of ethanol (in particular acetaldehyde dehydrogenase and alcohol dehydrogenase), which significantly accelerates the process of its elimination from the body and, as a result, reduces its toxic effect.
Drug features
What is remarkable about the Metadoxil medication? Instructions, reviews claim that its active substance prevents the formation of elements such as collagen and fibronectin, and also prevents the accumulation of triglycerides, which significantly slows down the development of liver cirrhosis.
It should also be noted that this tool is able to shorten the period of relief of withdrawal symptoms, reduce somatic and mental symptoms of a hangover syndrome.
It cannot be said that metadoxine activates the GABA-ergic and cholinergic neurotransmitter systems, interferes with motor excitation, and improves short memory and thinking. In addition, this substance is able to have a nonspecific anxiolytic and antidepressant effect, as well as reduce the craving for alcohol.
Kinetics
After taking the medicine inside, it is rapidly absorbed from the intestine. Metadoxine has a high bioavailability (approximately 60-85%). Its binding to plasma proteins is 50%.
This component is metabolized in the liver to the formation of active derivatives - pyrrolidone carboxylate and pyridine.
The half-life of the drug with parenteral administration or ingestion is 45-57 minutes. Approximately 40-50% of the drug is excreted with urine during the day and about 35-50% with feces within 95 hours.
Indications
Under what conditions is the drug “Metadoxil” most effective? Reviews of alcoholics claim that this tool helps well with:
- chronic alcoholism;
- in the complex therapy of liver diseases, including alcohol etiology;
- alcohol withdrawal syndrome ;
- alcohol intoxication, including acute.
Contraindications
The medication in question is contraindicated in:
- breastfeeding;
- bearing the fetus;
- high sensitivity to the elements of the drug.
With caution, this remedy should be prescribed for Parkinson's disease, especially if the patient is already using levodopa. This is due to the fact that metadoxine is able to reduce the effectiveness of the latter.
The drug "Metadoxil": instructions for use
Reviews report that the drug in question should be used only after consulting a specialist.
With alcohol intoxication, especially of an acute nature, this drug is administered intramuscularly in a dosage of 300-600 mg or intravenously - 300-900 mg.
With intravenous administration, the indicated dose of the drug is previously diluted in a 5% dextrose solution or with 500 ml of sodium chloride. In this form, the drug is administered drip for 1.4 hours.
As part of the combined treatment of liver diseases, as well as chronic alcoholism, this drug is prescribed 500 mg twice a day 25-35 minutes before a meal. This dose can be increased to 500 mg three times a day.
The course of therapy with this drug should last at least 90 days.
With withdrawal symptoms (alcohol), the medication is administered intravenously in the form of an infusion at a dosage of 900 mg once a day for 3-7 days (depending on the patient's condition).
Side effects
What are the negative effects of the drug "Metadoxil"? Reviews of alcoholics report that against the background of the use of this tool, they often develop allergic reactions.
It should also be noted that people with bronchial asthma may experience bronchospasm (most often when using a solution).
Special information
Metadoxil Injection Solution contains a component such as sodium metabisulfite. This substance can cause allergic reactions in people prone to asthma attacks, as well as their intensification.
The drug "Metadoxil": reviews of alcoholics
Unfortunately, there are not very many reviews about Metadoxil. However, from those left by people prone to alcoholism, we can safely conclude that this medication has a good effect in the treatment of alcohol dependence.
As for the effectiveness of the treatment of withdrawal symptoms, the patient reviews here differ markedly. Some argue that with this condition, the drug helps pretty well, while others did not notice any result.
There are also many negative messages about the price of this tool. As a rule, it is 1250-1450 rubles.