The drug "Vazonit-Retard" helps to improve microcirculation and rheological properties of blood, has a vasoconstrictor effect. The active ingredient - pentoxifylline - is a xanthine derivative.
The medication "Vazonit" promotes the inhibition of phosphodiesterase and the accumulation of cAMP in the cells of the smooth muscles of blood vessels, in the formed components of the blood, organs and tissues. The drug slows down the aggregation of red blood cells and platelets, increasing their elasticity. Describing the mechanism of action of the drug "Wazonit", the instruction indicates its properties to reduce the plasma fibrinogen content and enhance fibrinolysis. This leads to a decrease in blood viscosity. Along with this, rheological properties (fluidity) also increase. The drug helps to improve the oxygen supply to tissues in areas with circulatory disorders (in the limbs, kidneys, including the central nervous system). The medicine has a slight dilatory effect on the vessels.
When taken orally, a uniform and continuous release of the active ingredient and its absorption from the digestive system is ensured. Pentoxifylline and its metabolites reach a maximum concentration after three or four hours. The therapeutic concentration is maintained for 12 hours. Excretion is carried out by the kidneys.
The drug "Vazonit" application instruction recommends for disorders in the peripheral circulation (with Raynaud's disease, diabetic angiopathy, obliterating endarteritis). Prescribe a medication for angioeuropathy, dyscirculatory and atherosclerotic encephalopathy. Means "Vazonit" application instruction recommends for chronic or acute disorders in cerebral blood supply according to the ischemic type (ischemic cerebral stroke), circulatory disorders in the eye (for chronic, subacute or acute circulatory failure in the choroid or retina). The drug is prescribed for trophic changes in tissues as a result of disturbances in venous or arterial microcirculation (with frostbite, gangrene, trophic ulcers, varicose veins, post-thrombophlebic syndrome). The medication is also indicated for hearing impairment of a vascular nature, complicated by hearing loss.
The duration of the drug and the dosage regimen is set individually.
The medicine "Vazonit" instructions for use recommend that you assign a tablet twice a day (in the evenings and mornings). The drug is taken after a meal.
The medication "Vazonit" can provoke some undesirable consequences. Side effects include dry mouth, diarrhea, vomiting, a feeling of fullness in the abdomen, and an appetite disorder. Pain in epigastrium, jaundice, hepatitis or cholecystitis are likely. In rare cases, an unpleasant aftertaste in the mouth, convulsive states, anxiety, headache, scotoma, conjunctivitis can be noted. Adverse reactions include dizziness, earache, sleep disturbances, blurred vision.
Taking the medication in high doses leads to a decrease in blood pressure, disturbances in the rhythm of the heart, tachycardia, facial flushing, angina pectoris, “hot flashes”, and swelling.
Allergic manifestations are also likely during treatment. In particular, Quincke's edema, rash, urticaria, pruritus, anaphylactic shock (rarely) can be noted.
The drug "Vazonit" instructions for use does not recommend for extensive bleeding, acute heart attack, hemorrhagic stroke, porphyria. Do not prescribe medication to patients under eighteen years of age, with retinal hemorrhages, hypersensitivity. The drug "Vazonit" is contraindicated for pregnant women. Nursing should stop lactation while taking the medicine.
Before using the drug "Vazonit" should consult with your doctor.