According to the instructions for use, Amelotex suppositories have an analgesic effect. This drug is also known for its anti-inflammatory properties. In its composition there is a substance meloxicam. Among other basic functions, this product is also capable of producing an antipyretic effect.
Pharmacokinetics of the drug
The combination of the drug with plasma proteins is ninety-nine percent. It passes through histohematological barriers, penetrating into the synovial fluid. The product is excreted through the intestines and kidneys equally, mainly in the form of so-called metabolites. Less than five percent of the total daily dose is excreted through the intestine in an unchanged form; in the urine, the drug can be found only in trace amounts.
Indications for use
As indicated by the instructions for use, Amelotex suppositories are prescribed in order to eliminate such ailments as arthritis, ankylosing spondylitis or, in other words, ankylosing spondylitis, as well as for the treatment of inflammation and degenerative conditions. The directly active substance contained in the drug is meloxicam, which helps eliminate pain and osteoarthritis.
Candles "Amelotex" produced in two versions, depending on the degree of concentration of the active substance. Each package contains six suppositories.
Method of using suppositories
Candles are used only when, for some reason, the use of tablets is impossible. They are administered one at a time deep into the rectum in the morning or in the evening. The course of therapy lasts from two weeks to a month.
Contraindications for use
Amelotex suppositories should not be used if the following symptoms are present:
- Wounds, scratches and ulcers in the area where the product is intended to be used. Thus, Amelotex can be used only in those areas of the skin where there are no injuries.
- Inflammatory processes in the gastrointestinal system.
- Intolerance to the body of meloxicam, as well as general sensitivity to non-steroidal anti-inflammatory drugs, including allergic reactions to them.
- Renal and heart failure in patients.
- Polyposis of the nose and sinuses, bronchial asthma.
It should be noted that alcohol-containing drinks do not interfere with absorption and do not in any way affect the degree of effectiveness of the drug. True, it is necessary to take into account that Amelotex suppositories (the instructions for use confirm this) can have a negative effect on the liver and kidneys, for this reason it would be better not to give an additional burden to these organs, as well as completely stop drinking alcohol during therapy.
Pregnancy and lactation
The drug is forbidden to use during pregnancy, and, in addition, during lactation. This rule applies to all forms of release of this drug.
It is better for women who have difficulties in conceiving a child to choose some other medicine for treatment, since absolutely all drugs made on the basis of meloxicam have a depressing effect on fertility. For this reason, in gynecology, when planning a child for women, this drug is not prescribed.
You should also pay attention to the fact that injections with meloxicam can also affect the effectiveness of intrauterine contraceptives, as a result of which they reduce it.
How does Amelotex in the form of candles work? Let's figure it out.
The principle of action on the body of the drug "Amelotex"
When it enters the systemic circulation by any of the methods (through the skin, gastrointestinal system, and the use of suppositories), Amelotex is able to penetrate the affected cells, and, in addition, the tissues of the spine and its structure. In this area, a series of chemical reactions is launched, as a result of which the cyclooxygenase-2 substance is inhibited. Due to this, the blockade of inflammatory mediators, which are prostaglandins and leukotrienes, is caused. This action entails an anti-inflammatory effect.
The antipyretic effect of Amelotex suppositories (15 mg) depends on the blockade of inflammatory mediators, and is also associated with a decrease in the sensitivity of thermoregulation centers in the brain.
The analgesic effect is directly related to the ability of this medication to increase the degree of pain sensitivity, as well as block the center of pain in the brain area.
Safety precautions
In the event that the following symptoms are observed in patients, this drug should be used with extreme caution, the instructions for use confirm the use of Amelotex suppositories:
- Hyperkalemia along with coagulation disorders.
- The presence of stomach ulcers, as well as the duodenum, which are at the stage of their exacerbation.
- Bleeding in the digestive system.
- Inflammatory processes in the intestines, for example, ulcerative colitis or Crohn's disease.
- Progressive renal pathology.
- Active liver disease, including organ failure.
- Chronic heart muscle failure.
It is important to pay attention to the fact that if a person smokes, abuses alcoholic beverages, is ill with diabetes or is infected with Helicobacter pylori, then he is at risk and he should use this medication with caution. Candles "Amelotex" in gynecology are very popular.
The effect of Amelotex suppositories on the concentration of attention of patients
Using "Amelotex", patients should be aware that therapy can affect the ability to properly drive a vehicle. Against the background of its use, drowsiness is likely to occur, and it may also become dizzy. Some patients who are prescribed this drug may even develop severe headaches. Against the background of all this, the necessary concentration of attention drops noticeably, for this reason it will be best to refuse to work with all kinds of mechanisms that require maximum concentration.
For Amelotex candles, reviews and analogues will be considered below.
Interaction of the drug "Amelotex" with other drugs
When prescribing Amelotex for the purpose of therapy, it is important to bear in mind that the active substance meloxicam has the following effects:
- The drug should not be used simultaneously with acetylsalicylic acid.
- Along with myelotoxic drugs, such as Cyclosporin and Colestyramine, Amelotex should be used with great caution.
- An increase in the concentration of lithium in the blood plasma is provoked.
- Compatibility of Amelotex suppositories, according to reviews, with diuretics represents an additional risk of the possible occurrence of impaired renal activity.
- There is a possibility that antihypertensive drugs during the interaction with meloxicam will not be effective enough.
The Amelotex candles should be selected by a doctor.
Side effects from the drug "Amelotex"
Side effects are manifested in the manifestation in patients of symptoms such as hyperemia, peeling of the skin, allergic reactions in the form of burning, itching and urticaria. In addition, erythema multiforme, rashes of a papular-vesicular nature and photosensitivity are observed.
On the part of the skin, there is a likelihood of the formation of epidermal necrolysis. In relation to the respiratory system, the occurrence of bronchial spasms is not excluded.
The nervous system of the body is able to respond to the introduction of the drug with the following symptoms:
- The occurrence of tinnitus, the appearance of headaches.
- Decreased concentration along with confusion.
- Space disorientation and drowsiness. This confirms the instructions for the candles "Amelotex".
There is also the likelihood of disturbances in the functioning of the blood forming organs, which can be expressed in anemia, leukopenia and thrombocytopenia. On the part of the cardiovascular apparatus, there are risks of forming the following unpleasant symptoms:
- Edema of the peripheral type.
- Often observed increase in blood pressure.
- Cardiopalmus.
- The feeling of a rush of blood, which is most often felt in the chest area, as well as on the face. This is confirmed by the "Amelotex" instructions for use and reviews.
A lot of side effects can be called in relation to the functioning of the digestive system:
- The stomach can become sick and in parallel develop or aggravate gastritis.
- Hepatitis and hyperbilirubinemia are likely.
- Bleeding in the digestive organs, including those that occur in a latent form, is not ruled out.
- Violation of the stool occurs, with constipation and diarrhea, as well as colitis, belching and flatulence.
- Perforation of the organs of the gastrointestinal tract occurs.
- Increased activity of hepatic transaminases.
- Nausea, stomatitis, vomiting, esophagitis and erosive and ulcerative lesions of the digestive organs are likely.
Quite often, there are some malfunctions in the functioning of the urinary system, which are expressed in the form of hematuria, hypercreatininemia and albuminuria. On this basis, the development of interstitial nephritis and acute renal failure, which may be accompanied by swelling and an increase in the concentration of urea in the blood serum, also occurs.
Among other things, vision problems are likely, for example, a decrease in its severity and the occurrence of conjunctivitis. Often, patients develop allergic reactions to the substance of the drug, which result in angioedema.
This is indicated by the candles "Amelotex" instructions for use. In gynecology, analogues of the drug are also used.
Analogs
Similar to “Amelotex” properties and degree of influence are possessed by such medications as “Movalis” and “Meloxicam”.
The drug "Movalis" was developed in Germany, and its price reaches eight hundred rubles per package. This product is available in the form of tablets, as well as injections, suspensions and rectal suppositories, like Amelotex. Dosing, just like the method of using this medication, depends on the severity of the patient's disease.
The advantages of this medicine include the fact that it can be prescribed to adolescents, starting from the age of twelve. In addition, the drug acts as an original drug.
Its unconditional minus is the price, as well as the fact that it cannot be used while carrying a child, during the lactation period, and, in addition, against the background of the systematic use of alcohol.
As for Meloxicam, its price is significantly lower compared to the previous analogue and amounts to no more than three hundred rubles per package. This product is produced in Israel. It is released in the form of suspensions, tablets, as well as rectal suppositories and injections. It has an antipyretic, anti-inflammatory and analgesic effect.
The advantage is, as already noted, low cost. Due to the fact that this medical device has a protective shell, it does not have a noticeable negative effect on the digestive system.
The downside is a large list of all kinds of contraindications along with side effects. "Meloxicam" adversely affects the health of the liver and kidneys. In addition, there is a great opportunity to purchase a fake.
Reviews
As for the reviews about this drug, we can say that people quite often praise its effective degree of action against pain against the background of arthrosis and joint ailments. Indications of Amelotex candles can be clarified in the annotation.
So, patients unanimously declare that this medication works very successfully in the framework of the removal of certain pain sensations. People write that in order to consolidate the positive results, many had to repeat Amelotex therapy again, since the pain may return again against the background of its discontinuation.
The obvious disadvantages of people include an extensive list of side effects. True, directly on their own experience of treatment, patients did not feel any negative influence. The most common complaint regarding side effects is called headaches.
In addition, another disadvantage is the ban on the use of funds by pregnant and lactating women, and, in addition, by patients with impaired renal function with severe insufficiency of the proper activity of this body.
Some patients leave satisfied reviews about Amelotex suppositories and instructions for use, in which they indicate that this drug helped them cope with severe lumbar pain. Women report that after the first injection of the drug suppository into the rectum, they felt relief, and after the completion of the main course of therapy the pain completely disappeared. In such situations, doctors recommend repeating the procedure no earlier than six months later.
Most patients call Amelotex a very good analgesic and anti-inflammatory in their comments. They explain this assessment by the effective struggle of the drug against pain of the knee joints, which occurs due to strong physical exertion. People say that they felt a positive result almost immediately, which allows such patients to sleep without the use of analgesics.
Nevertheless, despite the large number of satisfied reviews, many people also note that the Amelotex drug is a rather serious drug, which should be treated with a great degree of caution and, of course, should be used exclusively as directed by the attending physician. But with all this, according to the comments of patients, this tool is recognized as a fairly effective product that helps to cope mainly with certain painful reactions of the body.