As you can conclude from the reviews, “Forsiga 10 mg” is a reliable drug that allows you to control blood sugar. However, there were some flaws. Many note: the tool allowed to completely abandon insulin. And yet, patients acknowledge the presence of side effects. Consider what are the opinions about this tool, we will analyze the rules for its use.
Relevance of the issue
As can be seen from the reviews of experts, "Forsiga" is a tablet product designed for people with diabetes. It is noted not only the effectiveness of the drug in terms of controlling the concentration of glucose in the circulatory system, but also the additional effect of enhancing drugs that stabilize cardiac activity. Against the background of taking the drug, as noted in the reviews about “Forsig 10 mg”, the pressure significantly decreased. Persons who have been prescribed this drug have been able to control the concentration of cholesterol in the circulatory system. The good points, however, go hand in hand with the flaws. So, other persons noted a complete lack of effect. Experts explain this with the individual characteristics of the body.
Endocrinologists' reviews of Forsig are predominantly positive, as are those taking these pills, but there are weaknesses in the drug. The medication provokes side effects that you need to be prepared for. Some had a febrile state, itching bothered, the frequency of urges to empty the bladder changed. Persons suffering from inflammatory processes in the reproductive, urinary systems, often experience exacerbations of these pathologies.
Is everything known?
As can be learned from the reviews of endocrinologists, “Forsiga” is a fairly reliable, although it has recently appeared on sale drug. Doctors note: the possible negative consequences that the medicine may cause are mentioned by the manufacturer in the accompanying instructions. Nothing sudden and unexpected happens. Specialists can warn patients in advance what the use of pills can lead to.
As patients' reviews say, “Forsiga” is accompanied by clear instructions. Persons who studied it in detail admit: there were no undesirable consequences of admission, other than those mentioned by the manufacturer. The instruction describes in detail and in detail how the tool works, and it is compiled in a fairly understandable language. It’s not difficult to understand even a person who is far from medicine. Separately, in the patient reviews of Forsig, the simplicity and comprehensibility of the instructions in aspects relating to the program of use are noted: everything is described clearly. This greatly reduces the likelihood of mistaken use of the drug by inattention.
Technical information
As can be seen from the reviews, the Forsig tablets are convenient and easy to use. The instructions describe the technical parameters of the drug. One tablet contains dapagliflozin in the form of propanediol monohydrate. In one tablet of this compound - 6.15 mg or 12.3 mg, which, based on the pure substance, corresponds to 5 mg and 10 mg, respectively. As additional ingredients, the manufacturer used cellulose, lactose, crospovidone, magnesium and silicon compounds. For the manufacture of the shell used opadray in an amount of 5 mg. The instructions describe the appearance of the drug. Many users also talk about how tablets look in their reviews about Forsig. Each copy is made in yellow, covered with a shell - a thin film. The tablets are in the shape of a circle. The product is convex on both sides. One of the sides is decorated with an engraving “5” or “10”, on the other a combination of numbers “1427” or “1428” is depicted.
As people who took this medicine indicate in the reviews about Forsig, each pack contains three blisters with a dozen tablets. According to buyers, the price of the drug is quite high. For packaging (30 tablets) in a pharmacy they ask from 2.5 thousand rubles.
Pharmacology
Are the reviews really telling about the good effectiveness of the drug? In the instructions for use for Forsig, the manufacturer describes in detail the pharmacological features of the medication, thereby explaining why it is effective and reliable. It also indicates that the agent belongs to hypoglycemic drugs used orally that inhibit glucose transport.
Studies have shown that dapagliflozin is a very powerful substance for selective inhibition of sodium and glucose transport. Expressed in the kidney. In the study of about 70 tissues of the human body, this compound was not found. It does not accumulate in the musculoskeletal system, fiber and glands, it is not in the bladder and brain. The transporter takes part in the process of reverse absorption of glucose in the tubules of the kidneys. In the second type of diabetic disease, hyperglycemia is not an obstacle to reverse absorption. Dapagliflozin slows down the transport of glucose, reduces the activity of the reverse absorption process, so glucose is more effectively excreted from the body with urine. The content of this component in the human body is reduced both before and after the meal. The content of glycosylated hemoglobin is reduced against the background of a diabetic disease of the second type.
Pharmacological features
In the reviews about the drug “Forsiga”, there was an increase in the frequency of urges to empty the bladder. As can be learned from the instructions, to some extent this is due to the glucosuric effect of the drug composition. This is fixed after using the medicine for the first time. The action lasts 24 hours, with continued administration - throughout the entire therapeutic course. The volumes of glucose excreted in this way depend on the content of this substance in the circulatory system and the rate of blood filtration by the glomeruli of the kidneys.
The active ingredient does not interfere with endogenous glucose generation processes. Its effect does not depend on the production of insulin and the susceptibility of this hormone by the body. Clinical trials were carried out, confirming the positive effect of the drug on the beta cells of the body. Renal elimination of glucose leads to a loss of calories. As you can conclude from the reviews, the use of Forsigi helps to some extent reduce weight. This is due to just such a mechanism for removing glucose. The active ingredient inhibits the action of sodium and glucose transport, while being a weak diuretic and natriuretic transistor. It does not affect the work of other substances that transport glucose and carry it to the periphery of the body.
Pharmacodynamics
Experiments were conducted involving healthy volunteers in order to determine the characteristics of the dynamics of the drug. People with the second type of diabetic disease were also attracted for experiments. In both cases, the volume of glucose excreted by the renal system increased. When using ten milligrams per day in a twelve-week course for the second type of diabetes, about 70 grams of glucose was excreted by the kidneys per day. With a long program (from two years or more), the indicators were maintained.
As you can conclude from the reviews about "Forsig", this drug increased urination for people taking it. In the instructions, the manufacturer draws attention to osmotic diuresis with an increase in the volume of fluids thus excreted from the body. Against the background of the second type of diabetic disease, when consumed ten milligrams daily, the volume remained increased for at least twelve weeks. The total amount reached 375 milliliters in 24 hours. Along with this, the activity of excretion of sodium by the renal system increased slightly, but the content of this trace element in the blood plasma did not change.
Studies and their results
Studies were conducted with placebo control. In total, thirteen such events were organized. As can be seen from the reviews about "Forsig", the drug allows you to lower the pressure - this is just confirmed by experiments with placebo. Blood pressure systole dropped on average by 3.7 units, and diastole - by 1.8. A persistent effect was observed by the 24th week of taking a dose of ten milligrams per day. In the placebo group, the decrease was estimated at 0.5 units for both parameters. Similar results were obtained by observation lasting 104 weeks.
The use of ten milligrams of the drug daily with inadequate glycemic control and high blood pressure is allowed in combination with ACE inhibitors that inhibit second angiotensin, drugs and other drugs that normalize blood pressure. With such multicomponent therapy, the content of glycosylated hemoglobin dropped by approximately 3.1%. Pressure systole steadily decreased by the 12th week of the course by an average of 4.3 units.
Pharmacokinetics
In reviews of “Forsig,” many note the rather rapid appearance of the first effect - a person’s condition stabilizes on the first day of using the composition. This is due to the rapid absorption of the active component. It is allowed to use tablets during the meal, after it. The maximum concentration of the active ingredient in the circulatory system is observed on average a couple of hours after using the composition on an empty stomach. The value of this value depends on the dose used. Absolute bioavailability with 10 mg is estimated at 78%. The meal moderately corrects the kinetics of the remedy in a healthy person. If you eat fat-rich foods, the maximum concentration of the active ingredient drops by half. The duration of stay in plasma increases by an hour. Such changes are not considered clinically significant.
As can be concluded from the reviews, “Forsig” diabetes in the case of the second type of disease helps well, quickly, reliably, while side effects, although they are, do not appear in everyone, are mostly predictable. To some extent, this is due to the characteristics of the reactions that occur in the human body. Serum protein binding is estimated at 91%. A study of individuals with various pathologies did not show a change in this parameter. Dapagliflozin is a C-linked glycoside. It is inherent resistance to glucosidases. The metabolic process proceeds with the generation of an inactive compound.
Breeding
The half-life of a healthy person from the blood serum was estimated at almost 13 hours with a single use of 10 mg of the drug. The active component and the products of its transformation are excreted by the renal system. About two percent of the basic substance is excreted in its original form. Tests were conducted using 50 mg of 14 C-dapagliflozin. 61 percent of the dose taken is metabolized to dapagliflozin-3-O-glucuronide.
When will it help?
"Forsig" is prescribed as a therapeutic agent for the second type of diabetic disease. The drug is used in combination with gymnastics for diabetics. During therapy, it is necessary to adhere to the nutritional treatment program. The medication is intended to improve the quality of control of glucose in the circulatory system. It can be used for monotherapy or combined with other medicines.
Allowed combination with preparations containing metformin, sulfonylurea processing products. You can practice a multicomponent course with inhibitory DPP-4 substances, insulin agents, thiazolidinediones. Forsiga is recommended when treatment with metformin is just beginning. The combination of these two drugs helps to increase effectiveness. Previously, the doctor must evaluate the feasibility of the combination.
Admission Rules
The medicine is formulated for oral use. The reception time does not depend on meals. For monotherapy, it is recommended to use ten milligrams of the drug daily. If combined treatment is needed, the recommended dosage is also ten milligrams daily. To reduce the risk of hypoglycemia with a multicomponent therapeutic course, it is possible to reduce the dosage of insulin or those agents that activate its generation in the body.
With the combination of Forsigi and Metformin, the first drug should be used daily at 10 mg, the second - 0.5 g. If it is not possible to adequately control the concentration of glucose in the circulatory system, it is recommended to increase the dosage of Metformin.
Impact Features
In case of malfunction of the liver functionality in mild and moderate form, special dosage adjustment is not required. In severe hepatic impairment, a treatment program should be started with a dose of five milligrams. If the body responds well, the volume is doubled.
The effectiveness of dapagliflozin is largely determined by renal function. In case of a malfunction of this organ of moderate severity, the effectiveness of taking the medicine is reduced. In severe failures, the effect is possible zero. You should not use the drug in question in severe, moderate degrees of renal failure, when creatinine clearance is less than 60 ml / min. You can not use the composition at the terminal stage. With mild renal failure, special dosage adjustments are not carried out.
Age and specifics
No studies have been conducted that would determine the effectiveness of taking the drug by minors. Not organized and such work that would reveal the safety of the course for this age group. Elderly people do not need dose adjustment. When designing a program, the doctor must consider the high risk of renal impairment. The clinical experience of administering the drug to people over 75 years of age is extremely limited. For this category of patients, the appointment of the drug in question should be avoided.
Is there an alternative?
What do patients say in the reviews? The analogues of Forsigi are drugs:
- Glucobay.
- Novonorm.
- Glibomet.
If it is not possible to purchase the composition prescribed by the doctor, the replacement must be agreed with the attending physician. The selection of an alternative depends on the diagnosis, concomitant diseases, the characteristics of a particular patient. Much is determined by the tolerance of various pharmaceutical products by the body. Sometimes the best replacement option is the drug "Invokana". They may recommend taking Jardins. The cost of the listed drugs is lower than Forsigi (except the last), but the effectiveness is slightly different, so self-replacement is categorically not recommended and may cause an undesirable course result.