Instructions for use with Mezim will be presented in this article. It is an enzyme that helps regulate digestion in the absence of natural enzymes in the body. It can also be used for overeating and some situations of temporary disruption of the digestive tract.
The composition of the drug
The main active substance in Mezima is pancreatin, which is an enzyme isolated from pig pancreas. The minimum enzyme activity of a drug is:
- Amylase - 4.3 thousand Heb. farm. units.
- Lipase - 3.5 thousand Heb. farm. units.
- Protease - 250 Heb. farm. units.
The auxiliary components of Mezim are:
- Sodium starch glycolate.
- Silica colloidal anhydrous.
- Hypromellose.
- Talc.
- Magnesium stearate.
- Azorubin varnish.
- Titanium dioxide.
- Simethicone emulsion.
- Macrogol.
- Dispersion of polyacrylate.
Release form
This medication is available in the form of cylindrical convex tablets, which are covered with a pink shell. They are packaged in blisters (10 tablets each). Blisters are packaged in cardboard boxes.
Pharmacodynamics
According to the instructions for use with Mezim, the basis of this polyenzyme preparation is the substance pancreatin, which is a powder obtained by extracting from the pork pancreas.
This active substance in the composition of the medication contains excretory enzymes - amylase, trypsin, chymotrypsin and lipase, which the body needs to digest the main components of food.
Pancreatin is not absorbed, is excreted with the contents of the intestine. The main part of the dose is denatured in the digestive tract under the influence of certain bacteria and digestive juice.
The main factors for the effectiveness of such a drug is its high lipolytic activity, as well as the dose of trypsin, while amylase plays a role only for patients with cystic fibrosis.
Dissolution of the tablet shell and the release of enzyme substances occurs exclusively in a neutral or slightly alkaline environment in the small intestine.
Indications for use of the drug
As indicated in the instructions for use, Mezim is intended to normalize digestive processes. The grounds for its use are the following conditions:
- Dyspepsia.
- The use of heavily digested, oily or unusual food.
- Flatulence associated with the above disorders.
- Some functional disorders that are accompanied by accelerated transit of intestinal contents.
What Mezim helps from, not everyone knows.
Diseases in which this drug is prescribed:
- Pathologies of the digestive tract, which are accompanied by disorders associated with insufficient production of necessary enzymes in the pancreas.
- Conditions after removal of certain sections of the small intestine or stomach.
- Some functional disorders that may be accompanied by accelerated transit of intestinal contents.
- Eating fatty foods.
- Bowel disorders, severe flatulence.
- As related measures in preparation for ultrasound or radiological diagnostic measures.
Mezim tablets are effective in the following diseases:
- Lack of exocrine pancreatic functions.
- Chronic inflammatory and dystrophic pathologies of the stomach, liver, gall bladder or intestines.
- Conditions after irradiation or resection of the above organs, as well as in cases where such conditions are accompanied by a violation of the digestion of food, diarrhea and flatulence.
- To eliminate the consequences of errors in nutrition and normalization of digestion in people with normal gland function.
- When infectious intestinal diseases, irritable bowel syndrome, etc.
Contraindications
As indicated by the instructions for use, Mezim should not be used in the following cases:
- With increased sensitivity to the main substance, in particular, to pancreatin, which is obtained from the gland of pigs, as well as to the food additives and dyes that make up the drug
- In acute pancreatitis.
- In cases of exacerbation of chronic forms of pancreatitis.
- Obstructive bowel obstruction that occurs when a mechanical obstruction occurs.
In the presence of pancreatitis, the drug can be used sporadically, for example, during the period of dietary restorative nutrition during the onset of remission.
Side effects of Mezima
Side effects from the medication can occur in the form of the following pathological conditions:
- Hypersensitivity reactions - sneezing, skin rash, lacrimation, bronchospasm.
- Digestive disorders, for example, in the form of nausea, diarrhea, pain in the epigastric region, changes in fecal characteristics.
- A variety of allergic reactions.
- In people suffering from cystic fibrosis, during the use of high doses of the drug, a narrowing of the colon is possible. Also, the possibility of increased excretion of uric acid is not excluded. To avoid stone formation in such patients, careful monitoring of uric acid concentrations in the urine is necessary. Side effects of Mezima are described in the instructions for use.
Method of using the medication and its dosage
Tablets are taken during meals, in general, unmilled, washed down with any liquid (water, juices, milk, tea, etc.). During adjuvant enzyme therapy, two to four tablets of the medication should be taken. The dosage of Mezima should be strictly observed. The duration of therapeutic courses is set in each case individually.
In the absence of recommendations, as well as during the use of vegetable, oily, as well as some unusual food, an adult needs to take one or two tablets.
Increasing the dosage of Mezima to relieve the symptoms of certain diseases should be carried out strictly under the supervision of a doctor.
Overdose
The symptomatology of a drug overdose is unknown and, based on the characteristics of its composition, is unlikely. It can manifest itself exclusively in the form of increased side effects.
It was found that in the treatment of high doses of drugs, the main active ingredient of which is pancreatin, the development of hyperuricosuria and hyperuricemia was observed in patients. The treatment of overdose symptoms is symptomatic.
What can Mezim tablets be combined with?
Drug Interactions
When using this medication, there may be a decrease in the absorption of folic acid, which, as a rule, requires its additional intake.
With concomitant therapy with drugs such as Miglitol or Acarbose, a decrease in the effect of the latter may be observed.
Analogs cheaper than Mezima will be considered below.
Precautions during the use of the medication
Intestinal obstruction is the most common complication in patients with cystic fibrosis. This means that when the symptoms that characterize this condition appear, it is necessary to keep in mind the possible intestinal complications.
The composition of this drug includes highly active enzymes that can sometimes cause damage to the oral mucosa, up to its formation of ulcerative lesions, so the Mezim preparation should be used in unbroken form without breaking or crushing the tablets.
It is contraindicated for people with congenital intolerance to galactose, as well as for lactase deficiency and for malabsorption of such substances.
There is no need to exclude activities related to increased concentration of attention (driving or using dangerous mechanisms).
So, what are the analogues cheaper Mezima?
Analogs
Like any other medicine, Mezim has many analogue medicines in the pharmaceutical market. These include:
- Mikrazim.
- Penzital.
- "Enzystal P".
- Pancreatin.
- "Creon."
- "Pangrol."
- "Pansitrat."
- Digestin.
- "Festal".
- The Hermitage.
- "Abomin."
- "Pancreoflat".
- Enterosan.
- "Pancreasim."
- Panzinorm.
- Panzinorm Forte.
What are the differences between medicines? What is more effective - Mezim or Pancreatin? They have exactly the same effect. Do not overpay. "Pancreatin" costs only 30 rubles. It contains slightly less enzymes, so Mezim is used for more severe pathologies. All other drugs with pancreatin in the composition differ from each other according to three criteria:
- Amylase is the most active enzyme. It contains "Creon", "Mikrazin" and "Panzinorm" in large quantities, and in a smaller one - Mezim-Fort.
- Additional components - in the "Festal" and "Enzistal" contains ham cellulose and bile.
- Form - most products are standard enteric-coated tablets, but Creon, Hermitage, Panzinorm are gelatin capsules.
What is the Russian analogue of Mezim? Often people prefer to buy only domestic drugs. Of all the analogues, many are produced by German or Indian pharmaceutical companies. Their cost is from 100 to 300 rubles. The most famous and cheapest domestic analogue of Mezima is Pancreatin. In addition to it, you can buy Vestal, Panzikam, Mikrazim and Panzim-forte.
At what age are Mezim prescribed?
Use in childhood
The drug is not contraindicated in the treatment of children. However, the dosage of the drug and the duration of such therapy should be established by specialists. Is Mezim suitable for pregnant women?
Use during pregnancy and while breastfeeding
There are no official contraindications to the use of this medication during pregnancy, however, as well as in cases of using it for the treatment of childhood diseases, the use of the drug should be prescribed by a doctor.
The manufacturer notes that the composition of the product includes enzymes that are absolutely identical to those that are produced directly in the human body by the pancreas. Lipase promotes the breakdown of fats, amylase - carbohydrates, and proteases come into relationship with proteins.
The auxiliary components of the drug are also not harmful to the body, moreover, pancreatin is not able to be absorbed and enter the bloodstream, but is excreted from the body naturally from the intestines.
Given all the above circumstances, experts often recommend taking this medication during pregnancy - to eliminate some digestive problems.
Pregnant women are advised to drink pills in a sitting or standing position, since in the prone position the drug moves more slowly along the esophagus and its premature dissolution may begin, which causes irritation of the digestive canal and oral mucosa.
The use of breastfeeding is possible only on the recommendation of a doctor, which is also not excluded with the appearance of some disorders in the digestive system, as well as with the development of diseases of the gastrointestinal system.
Patient Reviews About This Drug
As patients note, the drug is very good and effective. When the first symptoms of a violation of the functions of the stomach or intestines appear, you can take it once in a therapeutic dose, which helps to quickly eliminate these phenomena. Those who take Mezim systematically also respond very positively to this medication - an affordable, inexpensive and very effective remedy, which is its main characteristics. Negative reviews are not observed.
True, there are those who tried to replace the tool with its cheaper analogue. Patients claim that Pancreatin acts in exactly the same way, there is no particular difference. Therefore, why overpay for a similar drug?
What Mezim helps from is now known.