The drug "Valdoxan", the instructions indicate released in the form of tablets, each of them contains 25 mg of the active substance - agomelatine. The drug belongs to the clinical and pharmacological group of antidepressants.
The pharmacological effect is based on the ability of agomelatine to intensively release dopamine and norepinephrine directly in the area of the cerebral cortex. The amount of extracellular seratonin does not change.
The medicine "Valdoxan" improves the condition of patients suffering from chronic stress of moderate severity, a sense of despair and helplessness. Normalizes circadian rhythm desynchronization.
Tablets "Valdoxan" (analogues of the active substance are represented by the preparations "Agomelatine" and "Melitor") helps restore the natural structure of sleep, the formation of melatonin, and further lower body temperature. Stable positive dynamics are observed in patients with protracted depression after 6, 8 weeks of taking the drug in a daily dosage from 25 mg to 50 mg.
During clinical trials, a stable therapeutic result was established in patients with complex depressive disorders who took the recommended antidepressant “Valdoxan”.
The instruction indicates that this tool does not violate memory functions, concentration, when dosing 25 mg increases the phase of slow sleep, without changing the number of phases of REM sleep, their duration. Additionally, the active substance contributes to the treatment of disorders of the sexual sphere, normalizing the phase of excitement and orgasm. The weight of patients did not increase, blood pressure indicators remained unchanged, the drug did not affect the heart rate. After the abolition of agomelatine, a sense of addiction does not occur.
The medicine "Valdoxan", instructions, indications
The doctor prescribes a drug for the treatment of major depressive disorders in adults.
Dosage
Tablets are intended for oral use 1 time before going to bed. At the beginning of treatment, the doctor recommends taking 1 tablet of the Valdoxan drug, which in terms of the active substance is 25 mg of agomelatine. If the clinical picture does not improve after a two-week intake, then the dose is increased to 2 tablets, which means 50 mg of the drug.
During therapy, it is necessary to monitor the liver. The drug is intended for a long course of treatment, lasting up to 6 months, until all symptoms of the depressive state cease.
Side effect of the drug "Valdoxan"
The difficulty in determining side effects during treatment with the drug is that it is difficult to distinguish between the signs of the disease and the negative effects of therapy. The most common side effects that occur during treatment are nausea and dizziness, which quickly pass. In the vast majority of cases, discontinuation of the drug is not required.
Among the disorders in the functioning of the nervous system there is evidence of headache, drowsiness, insomnia, migraine, paresthesia.
Among mental disorders, there is evidence of anxiety, agitation, mania, suicidal behavior, although such symptoms may be a manifestation of the disease.
Among the disorders in the digestive system there is evidence of nausea, diarrhea, constipation, and abdominal pain.
Possible violations in the work of the hepatobiliary system.
Among other abnormalities in the body's work, there is evidence of sweating, eczema, itching, rash, visual disturbances, back pain, and general fatigue.
Contraindications
It is impossible in some cases to prescribe the medicine "Valdoxan". The instruction contains a list of conditions in which the use of this therapeutic agent is contraindicated:
- with liver failure;
- in combination with potent inhibitors of the CYP1A2 isoenzyme;
- for children under the age of 18;
- for patients with lactose intolerance;
- with increased sensitivity to one of the components of the drug.
The drug "Valdoxan" and alcohol are incompatible. When prescribing the drug to elderly patients, extreme caution should be exercised.