In this article, we will talk about the drug "Meloxicam-Prana." Instructions for use, reviews and recommendations of doctors are what will interest us in the first place. In addition, we will analyze in detail the indications, contraindications, side effects of the drug. And also consider the composition and pharmacological properties.
General information
Meloxicam-Prana belongs to a large group of anti-inflammatory non-steroidal drugs. Instructions for use (tablets) contain recommendations for the proper storage of the product. So, the drug must be kept in a dry, dark place, the temperature of which is in the range from 0 to 25 ° C. Under such conditions, the drug will be suitable for use for 3 years.
The tablets of the drug are available in 7.5 or 15 mg. They can be packaged in blisters of 10 tablets or in a plastic jar (from 50 to 100 pieces). Blisters or jars are packed in cardboard boxes along with instructions.
"Meloxicam-Prana" is available in pharmacies without a prescription.
Structure
“Meloxicam-Prana” (instructions for use confirms this) contains an active substance called meloxicam. Depending on the form of release, its amount in a tablet can be either 15 mg or 7.5 mg.
In addition, the composition of the drug includes the following auxiliary ingredients:
- microcrystalline cellulose;
- colloidal silicon dioxide ;
- magnesium stearate;
- corn starch;
- lactose monohydrate;
- croscarmellose sodium.
Pharmacology
“Meloxicam-Prana (the instruction contains this information) has analgesic, antipyretic and anti-inflammatory effects. The effectiveness of the drug is ensured by inhibiting the activity of COX-2 (cyclooxygenase), which is involved in the biosynthesis of prostaglandins in the place where the inflammation began. Much less the drug affects COX-1, which is involved in the synthesis of prostaglandins, which protect the gastrointestinal mucosa and are involved in the regulation of blood supply to the kidneys.
"Meloxicam-Prana" is well absorbed by the digestive tract. In addition, eating does not affect this process at all.
The drug is sufficiently accumulated in the body and begins to act actively during the 3-5-day intake. The level of meloxicam in plasma does not change even after taking the drug for more than 1 year.
The drug is completely metabolized by the liver, resulting in the formation of four pharmacologically inactive metabolites. The main one is carboxymeloxicam (60%). "Meloxicam-Prana" is excreted in the urine and feces. In elderly patients, the period of elimination of the drug increases.
Indications
In what cases can doctors prescribe Meloxicam-Prana? Indications for use, compiled by the manufacturer, are called the following diseases:
- rheumatoid arthritis;
- Ankylosing spondylitis (ankylosing spondylitis);
- osteoarthrosis.
However, the drug is prescribed only for symptomatic therapy, as it reduces pain and inflammation, but does not eliminate the causes of diseases and does not prevent their progression.
"Meloxicam-Prana": instructions for use
The tablets of the drug are available in two dosages - 15 mg of the active substance and 7.5 mg, so the doctor, prescribing the prescription, will focus on the form of release.
Patients with rheumatoid arthritis are advised to take 15 mg tablets. If the drug has a high therapeutic effect, then the dosage is usually recommended to be reduced to 7.5 mg.
People with a diagnosis of osteoarthritis are prescribed a tablet with 7.5 mg of the active substance. And only in the absence of the necessary effect increase the dosage to 15 mg.
Those who suffer from ankylosing spondylitis are prescribed 15 mg of the drug per day.
In all the situations described above, "Meloxicam-Prana" is taken 1 tablet per day with food. Raising the dosage without consultation is strictly prohibited.
For patients who are diagnosed with impaired renal function and may develop side effects, the daily dose of the drug should not exceed 7.5 mg.
Application features
Be sure to observe the precautions when prescribing and using the drug "Meloxicam-Prana". Instructions for use highlight patients who have been diagnosed with peptic ulcer of the duodenum or stomach and who have undergone anticoagulant therapy. This is due to the fact that in such patients the risk of developing ulcerative erosive lesions of the gastrointestinal tract is increased, therefore, “Meloxicam-Prana” should be taken with caution.
Also, with caution, the drug is prescribed for elderly patients, patients with chronic heart failure, liver cirrhosis, hypovolemia.
People taking the drug are not recommended to engage in activities involving various kinds of dangers and requiring increased attention, since the drug can cause dizziness, headaches and drowsiness.
Side effects
Has "Meloxicam-Prana" side effects.
Regarding the gastrointestinal tract, often (1% of cases) are observed:
- dyspepsia;
- vomiting
- nausea;
- constipation
- abdominal pains ;
- diarrhea;
- flatulence.
Rarely (from 0.01 to 0.1% of cases):
- belching;
- hyperbilirubinemia;
- esophagitis;
- gastrointestinal bleeding;
- gastroduodenal ulcer;
- stomatitis.
Very rarely (in 0.01% of cases):
- colitis;
- gastritis;
- gastrointestinal perforation;
- hepatitis.
The following changes may occur in the work of the cardiovascular system:
- peripheral edema (often);
- tachycardia (rarely);
- sensation of “hot flashes” (rarely);
- high blood pressure.
From the respiratory tract in rare cases, bronchial asthma can be observed.
Side effects associated with the central nervous system:
- dizziness (often);
- headaches (often);
- tinnitus (rare);
- drowsiness (rarely);
- vertigo (rarely);
- confusion (very rare);
- disorientation (very rare);
- emotional lability (very rare).
The following changes may occur in the urinary system:
- increased concentration of urea in the blood serum and hypercreatininemia (rarely);
- renal failure (very rare);
Dermatological side effects:
- skin rash;
- itching
- urticaria (rare);
- bullous rashes (very rare);
- increased photosensitivity (very rare);
- epidermal necrolysis (very rare).
Reactions from the hematopoietic system can be as follows:
- anemia (often);
- thrombocytopenia (rare);
- leukopenia (rarely).
The drug may cause allergic reactions. If the first signs occur, it is necessary to take an antihistamine drug, stop taking the drug and consult a doctor.
Contraindications
The drug "Meloxicam-Prana" (instructions for use contain clear instructions on this issue) is not prescribed in the following cases:
- hypersensitivity;
- full or partial combination of recurrent nasal polyposis, bronchial asthma, intolerance to acetylsalicylic acid;
- peptic ulcer of the duodenum and stomach (acute phase);
- severe renal failure;
- various bleeding;
- inflammatory bowel disease;
- various diseases of the kidneys and liver (progressive);
- severe heart failure;
- lactose intolerance or its deficiency;
- bronchial asthma.
Also, the drug is prohibited for children up to 12 children, pregnant and lactating women.
Interaction with other drugs
The following features can be noted when interacting with other drugs of the drug “Meloxicam-Prana” (instructions for use draws special attention to this):
- use together with other NSAIDs may increase the risk of opening bleeding of the gastrointestinal tract and the appearance of erosive-ulcerative deviations;
- the use of a drug with antihypertensive drugs can cause a decrease in the effectiveness of the latter;
- with simultaneous administration with drugs containing lithium, the toxic effect of the metal and the development of lithium cumulation may increase (it is usually recommended to control the concentration of lithium in the blood throughout the course of therapy);
- the appointment simultaneously with methotrexate can lead to an increase in the risks of leukopenia and anemia, therefore it is recommended to periodically conduct a general blood test;
- simultaneous use with cyclosporine and diuretics leads to the possibility of renal failure;
- while taking Meloxicam-Prana with intrauterine contraceptives, the effectiveness of the latter decreases;
- simultaneous use with thrombolytic drugs and anticoagulants (warfarin, heparin) significantly increases the risk of various bleeding, so it is necessary to monitor the level of blood coagulation in a patient during therapy;
- with simultaneous use with colestyramine, the amount of meloxicam excreted through the gastrointestinal tract increases.
Overdose
We examined in detail the instructions for use of the drug "Meloxicam-Prana", from which it helps, find out when it should not be taken - also indicated. Now, we list the symptoms of an overdose:
- nausea;
- impaired consciousness;
- gastrointestinal bleeding;
- epigastric pain;
- acute renal or liver failure;
- asystole;
- respiratory arrest.
If any of the above symptoms occur, immediately rinse your stomach and take activated charcoal. If necessary, symptomatic treatment is performed. A specially designed antidote does not exist.
"Meloxicam Prana: reviews
The tablets have many positive reviews from patients. So, the drug is highly effective and pleasantly pleased with the speed of action. Equally important is the availability of the drug in pharmacy chains. Despite the abundance and variety of side effects, they occur quite rarely.
However, there are a number of negative reviews about the drug. Basically, they are associated with disruption and exacerbation of various ailments of the gastrointestinal tract. But similar problems arise for the most part in patients even before taking the remedy.
Thus, “Meloxicam-Prana”, reviews of which are mostly only laudatory, proved to be a reliable and effective drug, which, however, is not recommended for people with various gastrointestinal diseases, especially acute ones.
It is necessary to pay attention to the fact that the drug is dispensed without a prescription, but this does not mean that you do not need to consult a doctor before using it. Also, it is not worth it to replace the prescribed drug on your own with Meloxicam, which may be its cheaper analogue. Be healthy!