In the article, we consider the instructions for use for the Tiogamma 600 preparation.
This drug is responsible for the regulation of carbohydrate and lipid metabolism. Instructions for use designate it as a metabolic drug. Alpha-lipoic acid contained in the preparation is an endogenous variety of antioxidant that has the ability to bind free radicals. With the use of Thiogamma, the glycogen content in the liver increases, and the amount of glucose in the blood decreases, which helps to overcome insulin resistance. Alpha-lipoic acid allows you to normalize the liver, as well as regulate carbohydrate and lipid metabolism, providing a stimulating effect on cholesterol metabolism.
Structure
According to the instructions for use, "Tiogamma" is produced in several forms, including:
- Pills in a shell. They have an oblong shape, light yellow with a splash. Available in packs of 30, 60 and 100 pieces.
- The solution for injection is a yellowish green or light yellow liquid. The drug is packaged in dark bottles in packages of 1 and 10 pieces.
- Concentrate for solution for infusion. The color of the liquid is yellowish green. It is produced in 20 ml vials of 5, 10 or 20 pieces per package.
Also, instructions for use with the Tiogamma 600? indicates that the active component is thioctic acid, presented in the form of a meglumine salt. The dosage of thioctic acid depends on the form of the drug:
- Tablet - 600 mg.
- Solution - 12 mg.
- Concentrate - 30 mg.
The tablets also contain a number of auxiliary components, including colloidal silicon dioxide, hypromellose, lactose monohydrate, croscarmellose sodium, simethicone, monocrystalline cellulose, magnesium stearate and talc.
Instructions for use with Tiogamma are very detailed.
The properties
Thioctic acid is responsible for the regulation of carbohydrate and lipid metabolism, as well as for cholesterol metabolism and contributes to the normal functioning of the liver and neural trophism. In addition, in case of intoxication provoked by salts of heavy metals, and other types of poisoning, the drug has a detoxifying effect.
If the patient has a history of diabetes, the use of the drug can improve endoneural blood flow, increase the content of glutathione to normal levels, and also improve the condition of nerve fibers on the periphery, impaired due to diabetic type neuropathy .
What else does the instruction manual for tablets “Tiogamma 600?” Tell us?
After oral administration, the drug is rapidly and completely absorbed from the digestive tract. When taking "Tiogamma" with food, the absorption of thioctic acid is significantly reduced. The peak effectiveness of the drug is observed half an hour after administration. The bioavailability of Tiogamma ranges from 30 to 60%. When passing through the liver, metabolism of thioctic acid occurs. The drug is excreted through the kidneys. The elimination half-life of thioctic acid takes approximately 25 minutes.
Indications
As indicated by the instructions for use, "Tiogamma 600?" in tablets, as well as a solution for droppers, are intended for the treatment of polyneuropathies of various origins as part of complex therapy. The drug is especially effective in eliminating the symptoms of alcohol poisoning and polyneuropathy caused by diabetes.
Contraindications
The drug is not intended for use by patients with hypersensitivity to the components of "Thiogamma". In addition, you can not take this medication to patients under the age of 18 years, as well as during the period of gestation and lactation. The latter is due to the likely effect of thioctic acid on fetal development or on the health of a newborn baby. In addition, "Tiogamma 600" in the form of tablets is contraindicated in the following cases:
- Lactase deficiency in the body.
- Glucose-galactose type malabsorption.
- Inherited galactose intolerance.
Before you start taking the drug, you need to consult a doctor to rule out contraindications and prevent the development of adverse reactions if possible.
Instructions for use "Thiogamma"
The medication in the form of tablets should be taken on an empty stomach, it is not recommended to chew it. Drinking a tablet is allowed a small amount of liquid. The standard dosage regimen is 1 tablet once.
Treatment is carried out for one to two months and is selected depending on the severity and nature of the disease. Repeated courses of therapy can be carried out up to three times a year.
It is important to tell the specialist during the consultation about all the drugs that are taken at the time of the survey. This is due to the poor compatibility of Thiogamma with certain drugs, including:
- Alcohol and its derivatives significantly reduce the effectiveness of thioctic acid.
- The active component of the drug increases the anti-inflammatory effect exerted by glucocorticosteroids.
- The effectiveness of cisplatin in combination with thioctic acid is reduced.
- Against the background of the simultaneous use of thioctic acid and insulin or other hypoglycemic substances, the effect of the latter is enhanced.
- Thioctic acid has the property of binding metals, so its simultaneous use with metal-containing preparations, including magnesium, calcium and iron, is prohibited. A break of at least two hours should be maintained between the two drugs.
This is stated in the instructions for use to the Tiogamma 600 ?. Reviews about the drug are abundant.
Adverse reactions
In general, Tiogamma 600 is well tolerated by patients. There are quite rare cases of the development of adverse reactions while taking the drug. However, the instruction lists the following possible adverse reactions:
- Digestive system - nausea and vomiting, diarrhea, abdominal pain in the abdomen.
- Nervous system - hyperhidrosis, dizziness, headache, visual disturbances, decreased blood glucose levels as a result of normalization of its absorption, signs of hypoglycemia.
- Allergic reactions - a rash on the skin, itching, urticaria, as well as systemic reactions such as anaphylactic shock.
This is confirmed by the instructions for use and reviews of the Tiogamma tablets.
The occurrence of adverse reactions indicates the need for drug withdrawal and medical attention.
Overdose
If the dosage of Tiogamma 600 is significantly exceeded, overdose symptoms such as nausea and vomiting, as well as headache are observed. In medical practice, cases of simultaneous administration of 10-40 g of thioctic acid in combination with alcoholic beverages were recorded, which led to severe intoxication of the body, and in some cases became the cause of death.
Against the background of an overdose, the manifestation of such symptoms as confusion, agitation of the psychomotor plan, which is accompanied by a generalized convulsive syndrome, is also possible. In addition, hypoglycemia, hemolysis, rhabdomylysis, bleeding disorders, shock and multi-organ failure are possible. Treatment of an overdose involves the elimination of symptoms, since a specific antidote for thioctic acid has not yet been developed.
Instructions for use for tablets "Tiogamma" does not contain information about analogues of the drug.
Analogs
A number of drugs are identified that have similar compositions and properties. In addition, the drug is produced in Germany, which explains its high cost and inaccessibility for some segments of the population. One package of the drug for 30 tablets will cost about 820 rubles. Therefore, many people opt for similar drugs manufactured in Russia and more affordable. The main similarity of all drugs is the presence of alpha-lipoic acid in their composition. Consider the most popular analogues of "Tiogamma 600":
- Oktolipen. It is produced in the form of capsules and concentrate for the manufacture of an infusion solution. The cost of the drug is approximately 400 rubles per 10 ampoules and 300 rubles per 30 capsules. The drug also regulates carbohydrate and lipid metabolism.
- Lipoic acid. The cheapest analogue of the drug, the cost of which is only about 50 rubles per package.
- "Berlition 300". This drug is most often prescribed instead of "Tiogamma 600". The cost is slightly lower than the original and is 700 rubles for 30 tablets. We will not consider in detail the instructions for use with Tiogamma analogs.
Before replacing one drug with another, it is important to consult a doctor, since a substitute may have a number of contraindications and features in taking. Details need to read the instructions for use.
Reviews about "Tiogamma"
Drugs that include thioctic acid are often prescribed for patients suffering from diabetes mellitus or in the presence of a tendency to develop neuropathic conditions. "Tiogamma 600" has a preventive effect and helps to prevent pathological processes in the peripheral nervous system. Thus, patients with the diseases indicated above manage to maintain working capacity over a long period.
After treatment, the risk of developing endocrine pathologies is reduced. At the same time, it was proved that adverse reactions are rare in patients. The drug is recognized by experts as effective and efficient.
The article presented instructions for use with the Tiogamma tablets.