One of the pharmacy names that is in great demand is Prednisolone. The use of tablets is possible only under the supervision of a doctor, since there is a high probability of adverse reactions if the conditions of appointment are not observed. The medication is one of the antiallergic. In addition to the tablet form, other release options are also on sale - a substance for injection, funds for external use (ointment, gel). We will analyze what the effectiveness of the prednisolone preparation is based on and how to use it correctly.
What is inside?
As can be seen from the instructions for use, Prednisolone tablets are based on the component of the same name, present in one portion in an amount of half a gram. To enhance the effectiveness of the product and simplify its use, the manufacturer adds other ingredients, listing everything used in the instructions. In particular, glycerin, petroleum jelly, water, an emulsifier, and special acids were used in the manufacture. People with allergic reactions to substances used in medicine should be especially attentive to this list. If Prednisolone was prescribed by a doctor, you should first inform your doctor of all possible negative responses of the body in order to prevent an unpleasant outcome of treatment.
Why use?
As follows from the instructions for use, "Prednisolone" (reviews confirm the effectiveness of the drug) is used to stop inflammatory processes, an allergic reaction of the body. The tool helps to cope with itching, has an antiexudative effect. Soon after the penetration of the active compound into the human body, the following is observed: the formation, release of inflammatory mediators is controlled, inhibited. "Prednisolone" has an effect on kinin, histamine, controls the activity of lysosomal enzyme compounds. Under its influence, cells cannot freely move to the inflammatory focus. "Prednisolone" reduces the permeability of the vascular walls in the area of ​​localization of the inflammatory process, inhibits vasodilation.
Exudation when using Prednisolone ointment (like tablets or ampoules) becomes less active. The process is due to the vasoconstrictor effect. The main compound of the drug is able to inhibit macrophages, cytokines, reduces the activity of target cells. Thus, it is possible to control all the elements of the body taking part in the development of contact dermatitis provoked by an allergic reaction. Under the influence of Prednisolone, target cells are protected from the effects of macrophages, T-lymphocytes, which have undergone sensitization.
What is going on inside?
If you follow the instructions for use, Prednisolone is well tolerated by the body, as medical research has shown. Soon after contact with tissues, adsorption occurs, the active compound quickly enters the circulatory system. This applies to all forms of drug release. Up to 90% of the total volume quickly enters the binding reaction with plasma proteins. "Prednisolone" is able to contact with albumin, transcortin. Biological processes of transformation - oxidation, localization - the liver. Metabolism products are soon excreted in urine and bile. A certain percentage leaves the body unchanged.
As medical studies have shown, the use of Prednisolone (injections, tablets, ointments) has severe restrictions on women in an “interesting” position, since the drug overcomes the placenta and can affect the fetus. A biochemical study of breast milk also showed a small percentage of the active compound, which imposes restrictions on the possibility of natural feeding of the baby when undergoing a therapeutic course.
When to use?
Reviews on the use of Prednisolone confirm that the drug is effective against a wide variety of allergic diseases. It can be used to stop the inflammatory process. The tool is designed as an element of complex therapy and is suitable for the treatment of cases only that are not provoked by microbial infection. "Prednisolone" can be used against urticaria, some forms of lichen and dermatitis, eczema, lupus. The tool is effective for a number of reasons for hair loss. The features of the application are best coordinated with the doctor, who first takes the tests to determine the nature of the problem.
Sometimes you can’t
Instructions for use "Prednisolone" contains a number of restrictions on the use of the drug. In particular, the tool is not intended for the treatment of persons suffering from hypersensitivity to the active component or any other compound used in the manufacturing process. Do not use (externally or orally) Prednisolone if skin lesions are triggered by a fungal infection or a microbial infection, a virus. The medication is not intended for the treatment of ulcers, it is not suitable for open wounds, it is dangerous for people suffering from trophic ulcers. You can not use Prednisolone if the patient’s allergic response is provoked by a vaccine that causes a reaction to the skin.
Instructions for use of Prednisolone contain restrictions on the use of the drug by persons diagnosed with syphilis and tuberculosis. The medication is not intended for pregnant women and nursing women, children one year old and younger. You should not use the drug if skin tumors are detected, acne is worried - the active substance can provoke an exacerbation of the disease. In some cases, with these conditions, the doctor may decide whether to use Prednisolone. In this case, the patient will have to warn about all the risks associated with such therapy, as well as to identify a line of behavior in case of adverse reactions.
Special case: we treat babies
The use of Prednisolone in children has a number of specific features. If the baby is one year old and younger, medication is strictly prohibited. For persons older than one year, the tool can be used, but in limited quantities and under the supervision of a specialist. It is necessary to prevent situations that could provoke a large absorption resorption of the active compound. It is not allowed to use dressings for fixation, warming, occlusive. When applying, take into account that the skin folds of babies can affect in a similar way, like occlusive dressings. Such an effect can give diapers, diapers. Under the influence of these factors, systemic resorption becomes higher.
Another feature of the use of Prednisolone in the treatment of young patients is associated with other ratios of mass and area of ​​the skin. This leads to an increased likelihood of suppressing the functioning of the adrenal glands, hypothalamus, pituitary gland. Consequently, the risk of Itsenko-Cushing's syndrome is growing. Long-term therapy can cause developmental disorders, growth. To prevent negative effects, it is recommended to use Prednisolone at the lowest possible dosage and under the constant supervision of a specialist.
Therapy Features
As follows from the instructions for use, Prednisolone is intended for a two-week course or shorter use. For longer than 14 days, the product is categorically not recommended. Certain restrictions are associated with the localization of the reaction, to eliminate which the drug is used. If the external form (ointment, gel) is chosen, it can not be applied near the eyes, since such a practice can provoke cataracts, glaucoma. If therapy involves the treatment of a one-year-old (and older than a child), if the drug must be used externally and applied to the face, to the area covered with a special dressing, you will have to shorten the therapeutic course. In order to avoid a negative response of the body, the medication should be used strictly under medical supervision.
Instructions for use of Prednisolone warns that in the treatment of young patients, the likelihood of inhibition of adrenal gland functionality is higher. There is a chance of reducing the excretion of the hormonal compound. If there is a need for a long therapeutic course, it is important to monitor the patient's weight, change in growth, plasma concentration of cortisol.
Accuracy will not hurt
As follows from the instructions for use, Prednisolone in the form of an ointment, gel does not affect a person's ability to give attention, does not affect the reaction rate. When taking such a therapeutic course, you can engage in various activities associated with potential danger, including driving machines. The speed of mental, motor reactions during the course does not suffer if the tool is used in accordance with the recommendations of a doctor, manufacturer.
How to use externally
Instructions for use of the ointment "Prednisolone" contains an indication of the need for applying the drug in a thin layer to the affected skin areas. Frequency of use - up to three times daily. The duration of the therapeutic course is determined by the specific features of the disease, the response of the body, the degree of effectiveness of the selected treatment method. Typically, the course takes from six days to two weeks. In some cases, the doctor may recommend using the ointment in the aftercare format for a longer time period, reducing the frequency of use to once a day.
A special approach requires the treatment of such parts of the body where the skin is of increased density. This applies to the feet, elbows, palms. The manufacturer in the rules indicates that the use of "Prednisolone" may be more frequent. A similar approach requires the treatment of such areas of the skin, where the drug quickly erases. To increase the effectiveness of applying the active component, an occlusive dressing can be applied. This is allowed only for limited inflammatory, allergic foci and only with the agreement of the doctor, with good tolerability.
Unpleasant effects: what to prepare for?
The use of "Prednisolone" in case of intolerance to any of the components is associated with a high probability of edema, skin itching in the areas of use of the medication. Possible hyperemia, acne. Sometimes the skin becomes dry, irritated. In rare cases, this effect is also manifested with normal tolerance of the components. Prolonged use may cause an infectious secondary skin lesion. "Prednisolone" can provoke atrophic processes, hypertrichosis. To prevent possible negative outcomes, “Prednisolone” should be used simultaneously with antimicrobial compounds and drugs to eliminate fungal infection.
A long course of treatment can cause increased corticism. This is especially characteristic if the use of Prednisolone is necessary in sufficiently large areas. This effect is due to the resorptive ability of the active compound. If a similar adverse reaction is recorded, an urgent withdrawal is required. In case of any negative reaction of the body to Prednisolone, it is necessary to consult a doctor as soon as possible. A particularly dangerous situation develops if the answers that are raised are not indicated as possible in the instructions for the tool. It is necessary to inform the specialist regarding all unpleasant impressions associated with the application of ointment, gel.
Too much!
Regardless of the chosen form of use, Prednisolone can be overdosed. It is possible to suspect the effect of Itsenko-Cushing. Inhibition of the pituitary, hypothalamus, adrenal glands is likely. To exhaust symptoms, under the supervision of a doctor, gradually stop using the medication.
If an overdose is detected, along with a decrease in the amount used, symptomatic therapy is also required. Sometimes it is additionally necessary to adjust the electrolyte balance in order to bring the body systems to a normal state.
Can you be together?
The use of "Prednisolone" (ampoules, tablets, ointments) in combination with other drugs can cause an activation of the influence of any of the compounds or lead to the opposite effect. In particular, if a patient uses anticoagulants, their water activity by exposure to the main substance under consideration becomes higher, but when combined with salicylates, the risk of bleeding increases. Taking diuretics and Prednisolone can lead to a situation of electrolyte balance problems, and cardiac glycosides become more toxic.
If Prednisolone injections (instructions for use must be strictly followed!) Are recommended for people with diabetes, you need to remember about the inhibition of the hypoglycemic effectiveness of the medicines used by this group of patients. If a patient undergoes treatment with rifampicin, its antimicrobial effect also weakens. Prednisolone should not be used with antacids.
Effectively and efficiently
As can be seen from the instructions for use of the prednisolone ointment (reviews confirm the effectiveness of this drug), the drug is able to deal with shock conditions, eliminates toxicosis. The drug belongs to the category of immunosuppressive. Use in a high dosage inhibits collagen synthesis. Protein catabolism in muscle fibers is becoming faster. At the same time, the production of protein by the liver is activated.
The antishock effect, as explained by the instructions for the use of Prednisone (in ampoules on the pharmacy shelves a medication for injection is presented), is associated with an effect on the circulatory system, an activation of the response to compounds that can narrow the lumens. At the same time, receptor sensitivity to catecholamines is restored. The hypertensive effect of the compounds is enhanced. When Prednisolone enters the body, water and sodium are retained.
Features: how it works
As follows from the instructions for use, Prednisolone in ampoules is more suitable for adults than for the treatment of children. Such a tool stimulates the hepatic processes of the production of protein compounds, due to which the medication has an antitoxic effect on the patient. In liver cells, metabolites that are toxic to humans are more rapidly inactivated, xenobiotics are processed. Water cell membranes become more stable when exposed to the active compound Prednisolone. This affects hepatocytes.
Liver cells under the influence of the drug more actively deposit glycogen. Protein metabolism affects glucose synthesis, and the growth of this component in the blood provokes the release of insulin. As follows from the instructions for use, Prednisolone (the drug is also suitable for children) does not allow fat cells to receive glucose, due to which lipolysis proceeds more actively. Increased insulin production causes lipogenesis, which is the basis for the accumulation of fat. Under the influence of the active compound, calcium is absorbed through the intestinal tract with lower productivity of the process, but is more quickly washed out of the bones, leaving the body through the kidneys.
Specific impact
The instructions for use of Prednisolone in ampoules for children and adults (as well as another form of the drug) indicate that the excitability of brain tissue increases under the influence of the compound. This leads to a certain decrease in the threshold for a convulsive state. Therapy with the drug requires careful attention and constant monitoring of the patient's condition. This is especially true in the treatment of young patients.
Medical studies have shown that the use of Prednisolone leads to an excess of hydrochloric acid in the stomach. The drug activates the processes of pepsin production. If the patient is sick with a peptic ulcer, this leads to a worsening of the condition, and healthy people have a risk of developing such a pathology.
Ampoules: when to use?
In this format, Prednisone is intended for the treatment of systemic pathologies that affect muscle tissue. The tool is effective in some forms of periarthritis, lupus, helps with ankylosing spondylitis. "Prednisolone" is prescribed as part of the therapeutic course of scleroderma, dermatomyositis. You can use the drug against blood diseases, including purpura, leukemia, anemia and some other pathologies. : , , , . «» .
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In rare situations, the doctor may prescribe an increased dosage of the medication, if he sees the obvious evidence. Such a decision must be made by analyzing the individual characteristics of the course of the disease. It is strictly forbidden to independently increase the dose due to the high likelihood of side effects.
If the drug is used to treat joints, 30 mg is required for an adult patient when treating a large joint area. For medium-sized joints, 10-25 mg is enough, for small ones - 5-10 mg. Injections are done every three days, the duration of the therapeutic program is three weeks.
Usage restrictions
“Prednisolone” is not intended for the treatment of persons who have recently had a history of viral pathology, fungal infection or bacterial infection. You can not use the drug if such a disease is currently available. This restriction applies to some types and forms of herpes, smallpox and measles, mycosis in a systemic form. The drug is dangerous for people who are suspected or accurately diagnosed with strongyloidosis. "Prednisolone" is not used for amoebiasis, tuberculosis, not only in active form, but also in latent.