Retinol acetate is made in the form of drops for oral and external use of 3.44% and 8.6%. The oily liquid is yellow in color, without aroma.
The solution is placed in glass vials. In addition, the drug is also produced in capsules. They are yellow in color and spherical in shape.
Structure
According to the instructions for retinol acetate, the oil solution for oral administration and external application of 3.44% and 8.6% contains:
- retinol acetate;
- food supplement E320;
- sunflower oil.
One capsule of retinol acetate contains:
- retinol acetate;
- sunflower oil;
- glycerol;
- para-hydroxybenzoic acid methyl ester.
Pharmacological properties of vitamin A
According to the instructions for use, it is known that retinol acetate is a necessary substance for the normal functioning of the retina of the eye. In addition, vitamin A takes part in the processes of bone formation, as well as embryonic development, provides stable reproductive function, and improves immunity.
When is the medicine prescribed?
According to the instructions for use with retinol acetate, the oil solution is used for vitamin deficiency A, as well as hypovitaminosis and as part of a complex treatment:
- Hemeralopia (ophthalmopathology, which is characterized by a violation of visual adaptation to low light conditions).
- Retinitis pigmentosa (a hereditary lesion of the retina of the organs of vision, in which dystrophy of the pigment epithelium occurs, as a result, various disorders develop).
- Xerophthalmia (a disease that is characterized by the drying of a thin transparent tissue covering the eye outside and the back surface of the eyelids and cornea).
- Eczematous lesions of the eyelids (inflammatory damage to the skin in the eye area).
- Ulcers (inflammatory lesion of the epithelium of the skin or mucous membrane).
- Ichthyosis (skin disease, which is characterized by a violation of keratinization of the epidermis).
- Psoriasis (a chronic lesion of the epidermis that covers mainly the skin).
- Hyperkeratosis (the state of the surface layer of the epidermis, which is expressed in an increase in the number of keratin cells of the cornea of the skin without changing their structure, leading to a thickening of the affected area).
- Tilotic eczema (a skin disease characterized by damage to the hands and feet).
- Neurodermatitis (a skin disease of a neurogenic-allergic type, which occurs with remission and exacerbations).
- Burns.
- Conjunctivitis (an inflammatory lesion of the mucous cavity that covers the inner surface of the eyelids).
- Superficial keratitis (inflammation that covers the upper layer of the cornea).
What diseases still use the drug
The medication perfectly copes with a number of diseases and pathological conditions:
- Rickets (a disease of young children with impaired bone formation and low bone mineralization).
- Collagenosis (pathological conditions that are combined by the same type of functional and morphological changes).
- Frostbite.
- Erosion.
- Cracks.
- Seborrheic dermatitis (a chronic inflammatory lesion that covers those parts of the skin of the head and body that have sebaceous glands).
- Tuberculosis of the skin (an infectious disease that has a prolonged course with frequent repetitions due to the population of the skin and subcutaneous tissue with mycobacterium tuberculosis).
- Gastrointestinal ulceration.
- Erosive gastroduodenitis (an inflammatory lesion that is characterized by a violation of the epithelial layer of the stomach and duodenum and the formation of erosion).
- Measles (an inflammatory lesion characterized by damage to the epithelial membrane of the gastrointestinal tract).
- Dysentery (an infectious disease characterized by general infectious intoxication syndrome and damage to the gastrointestinal tract, usually the distal colon).
- Tracheitis (a disease that is characterized by inflammatory disorders of the mucous membrane of the trachea, which is a manifestation of respiratory diseases that occurs both acutely and chronically).
- Influenza (acute respiratory disease caused by the influenza virus).
- Bronchitis (a respiratory disease in which the bronchi are involved in the inflammatory process).
- Atopic dermatitis (a disease that develops in patients with a genetic predisposition to the disease, has a recurring course).
Contraindications
According to the instructions for use with a solution of retinol acetate, it is known that restrictions on the use are:
- Acute inflammatory lesions of the skin.
- Gallstone disease (a disease characterized by the formation of gallstones or bile duct stones).
- Pregnancy.
- Hypervitaminosis A (acute disorder subsequently intoxication with an ultrahigh dosage of one or more vitamins).
- Chronic pancreatitis (a progressive inflammatory and destructive lesion of the pancreas, which leads to a violation of its externally and intrasecretory function).
- Age to seven years.
According to the instructions for use with retinol acetate, the oil solution with extreme caution, only after the doctor’s permission can be used in the following conditions:
- Cirrhosis of the liver (pathological damage to the liver, which is considered to be the result of impaired microcirculation in the system of hepatic vessels and dysfunction of the bile ducts).
- Viral hepatitis (a liver disease that is expressed in organ damage and impaired functioning).
- Kidney disease.
- Retirement age.
- With heart failure of the second and third degree.
- Jade (an inflammatory lesion of the kidneys, which in most cases leads to the fact that the tissues of these paired organs change).
Instruction manual
Retinol acetate 3.44 (oil solution) is used only under the supervision of a medical specialist. Drops for oral administration are taken after a meal, after ten to fifteen minutes.
For mild to moderate vitamin deficiency, adult patients are prescribed 13 drops of a solution of 3.44% from a pipette or 8.6% of the drug, 5 drops per day.
In case of damage to the organs of vision, adults are recommended to use 20-40 drops of the drug 3.44% or 8-16 drops of 8.6% retinol acetate per day. Children (taking into account age) are prescribed 0.01-0.05 milliliters 3.44% (one or two drops) or 0.004-0.02 ml of medication 8.6% (one drop) per day.
For skin diseases, adults are advised to use 0.5-1 milliliter 3.44% of the drug (from 20 to 40 drops) or 0.2-0.4 ml of 8.6% drops (from 8 to 16 drops) per day.
According to the instructions for application of retinol acetate to the solution, children are prescribed 0.05-0.2 milliliter drops of 3.44% (2 to 8 drops) or 0.02-0.08 ml of the drug 8.6% (1 to 4 drops) per day.
The doctor determines the duration of therapy individually. In the treatment of ulcers, as well as burns and frostbite, it is recommended to simultaneously treat the affected areas of the skin with an oil solution of retinol acetate. For this, a medication is applied to the cleaned epidermis six times a day, then covered with gauze.
What negative effects may occur
According to the instructions for use, the following symptoms are likely in the treatment of retinol acetate:
- Drowsiness.
- Migraine (a neurological disease that is characterized by regular or rare bouts of headache).
- Lethargy.
- Nausea.
- Confusion.
- Vomiting.
- Hyperemia of the face (increased filling of blood vessels).
- Impaired gait.
- Bleeding gums.
- Hyperhidrosis (a pathological condition that is accompanied by high sweating throughout the body or only in separate areas - in the armpits, on the feet or palms, in large folds).
- Vertigo (dizziness, temporary loss of coordination).
- Doubling in the eyes.
- Irritability.
- Diarrhea.
- Increased intracranial pressure.
- Pain in the bones.
- Lack of appetite.
- Gastralgia (pain in the stomach cramping type).
- Heat.
- Peeling lips.
- Fast fatiguability.
- Pollakiuria (a condition for which an increase in the frequency of urination is considered characteristic, but the volume of discharge remains normal in this case).
- Cracks and dry skin.
- Nocturia (the prevalence of nighttime urination over daytime).
- Polyuria (increased urine output per day).
- Photosensitivity (reaction of the skin to sunlight with the participation of the immune system).
- Hair loss.
- Oligomenorrhea (an increase in the interval between menstruation).
Recommendations for use
Retinol acetate cannot be used simultaneously with other vitamin-mineral complexes that contain vitamin A to prevent hypervitaminosis. For adult patients, the daily need for retinol is 0.9 mg, for children - 0.4-1 milligrams.
For women during lactation and children, the dosage should be increased by about 50%. The use of the drug in the recommended concentrations has no effect on the ability to drive a car and complex mechanisms.
According to the annotation, vitamin A is forbidden to use for therapy during pregnancy.
When treating young patients from seven years of age, the drug should be used with extreme caution. In case of kidney diseases, retinol acetate must be used with caution, in these cases the doctor selects the dose.
You can not use vitamin A preparations with prolonged treatment with tetracyclines, since such a combination can provoke intracranial hypertension. With the combination of retinol acetate with oral contraceptives, the level of vitamin A in the blood increases. With simultaneous use with glucocorticosteroids, salicylates, the risk of developing negative effects decreases.
"Colestipol", "Cholestyramine", "Neomycin" reduce the absorption of the drug. "Isotretinoin" increases the likelihood of a toxic effect. Calcium preparations lower their pharmacological effect, provoking the risk of hypercalcemia. "Tocopherol" causes a decrease in deposition in the liver.
Generics
Preparations - substitutes for retinol acetate solution:
- Vitamin A.
- Retinol palmitate.
- Retinol
How to store Retinol Acetate
Keep the drug out of the reach of children. It is necessary to keep the medicine at a temperature: solution - up to ten degrees of heat, capsules - up to plus twenty five. The drug should be stored away from light, protect the capsules from moisture. The shelf life of the solution and capsules is 24 months. The medicine is dispensed without a doctor’s prescription. The cost of the drug varies from 80 to 200 rubles, depending on the type of drug and the manufacturer.
Patient opinions
Reviews of the retinol acetate acetate oil solution for the face confirm its increased effectiveness. People say that consuming vitamin A helps to quickly improve hair condition and get rid of acne.
In addition, it is highly effective in eliminating acne, so retinol acetate is added to different masks and creams for the skin. There are already finished products with vitamin A content, but many people make such products themselves. You can add a couple drops of vitamin to the cream or mask and mix thoroughly. In this case, the product must be stored tightly corked in a cool place. Keep the cosmetic product away from sunlight.
With the help of this drug, it is possible to restore a withering skin integument not only on the face, but also in the decollete. Over the years, wrinkles in this area become more noticeable, vitamin A tones the delicate skin.
To enhance the positive effect, you can try retinol mixed with dairy products. Adverse reactions develop, as a rule, very rarely and do not require medical intervention.
Be careful, add no more than 1-2 drops of the solution to cosmetics. In the case of vitamin A, it no longer means better. In case of an overdose, an allergic reaction is possible - redness, peeling of the skin.
According to doctors, the drug reduces the thickness of the superficial cornea of the skin by accelerating the exfoliation of cells, which helps the epidermis have a more even texture and look younger.
Retinol acetate improves the thickness of the deep layers of the skin. The medication enhances the production of fibrillar protein and elastin in the epidermis. Accordingly, this helps to reduce wrinkles and fine lines on the face, and also increases the elasticity of the skin.
According to the responses of patients and doctors, the drug fights against acne. This is due to the fact that retinol eliminated most problems with hair follicles. In addition, a solution of retinol acetate in oil helps to reduce the secretion of the sebaceous glands, and also dissolves the substance that acne consists of, which helps cleanse the pores. That is why vitamin A is considered the best drug in the treatment of acne. The drug is often prescribed to adolescents to solve age-related skin problems.