The Indian drug is produced by Indian pharmacists, but it has become popular in our country due to its many positive aspects, and the main one is the ability to quickly reduce or completely suppress pain syndrome of various origins. The drug "Nice" (tablets), the instructions for use relate to anti-inflammatory non-steroidal drugs that can exhibit analgesic, antipyretic and anti-inflammatory effects.
The pharmacokinetics of this drug in the instructions are described as follows:
After oral administration, this medication is well absorbed. Since it circulates in the blood in a state bound to blood proteins, when used together with other drugs, nimesulide is able to displace them from bonds with proteins and, accordingly, increase the concentration of their free fractions in the blood. The fact of the use of the drug “Nice” together with food (tablets) is described by the instructions for use as a factor slowing down the absorption of the active substance, but in no way affecting the degree of its absorption.
Indications for its use are as follows: myalgia, the most diverse etiology of arthritis, arthralgia, various genesis of fever, algodismenorrhea, bursitis, headaches and toothaches, tendonitis, post-traumatic and postoperative pain, osteoarthritis.
Contraindications for the drug "Nice" (tablets) are instructions for use by the kidney and liver failure, hypersensitivity to the components of the drug (especially nimesulide), diseases of the digestive tract, internal bleeding (especially from the digestive tract), pregnancy, and the period of breastfeeding. Also a contraindication is the age of patients up to twelve years. With caution, the drug "Nice" (tablets), the instructions for use are recommended for patients suffering from arterial hypertension, type 2 diabetes mellitus, heart failure.
For the drug "Nice" (tablets), the composition in the instructions is as follows: the main active ingredient of nimesulide is one hundred milligrams, excipients.
"Nice" tablets are taken orally one at a time twice a day, before meals, with a sufficient volume of liquid. If the patient also suffers from pathologies of the digestive tract, then the drug “Nice” (tablets) recommends taking the instructions for use after eating, or at the end of its intake. The maximum allowable dose per day is four hundred milligrams.
For children over twelve years old and weighing more than forty kilograms, it is prescribed on the basis of this calculation: one and a half milligrams per kilogram of body weight. For this age and weight category, the drug is allowed to be taken at a dose not exceeding five milligrams per kilogram per day.
For children over the age of twelve years, but with a body weight that does not reach forty kilograms, the Nice drug (tablets) recommends the use of one hundred milligrams twice a day. The duration of treatment is ten days.
Side effects that the medicine "Nice" can provide, the instruction to it lists such:
From the digestive tract, nausea, diarrhea, vomiting, heartburn can occur, in the liver - an increase in the activity of transaminases, toxic hepatitis, the mucous membrane of the digestive tract can also ulcerate. From the nervous system, headaches and dizziness are sometimes noted. From the circulatory system - the development of anemia, agranulocytosis, thrombocytopenia, leukopenia, an increase in the time interval necessary to stop bleeding, hematuria. Allergic reactions of various intensities, fluid retention in the body can also develop.