The drug "Metformin" refers to the oral hypoglycemic agents of the biguanide group. When used by patients with diabetes, the drug reduces the level of glucose in the blood by suppressing gluconeogenesis in the liver, as well as lowering its absorption from the digestive system. Due to the increase in tissue sensitivity to insulin, its (glucose) utilization increases. Medication "Metformin" (reviews of experts indicate this) has an effect on lipid metabolism.
The drug helps to reduce the content of triglycerides,
LDL, serum cholesterol . The medicine also reduces (stabilizes) increased body weight. With penetration, the absorption of the drug is about 48-52%. With the simultaneous use of food, absorption decreases. The maximum concentration reaches after 2-3 hours. The drug binds slightly to plasma proteins, is metabolized to a weak degree.
Means "Metformin". Application
A medicine is prescribed for the second type of diabetes (sugar) in adults (especially those who are obese) in the absence of the effect of physical activity, diet therapy. Medication "Metformin" (reviews of doctors testify to this) can be used both as monotherapy, and as part of a complex of hypoglycemic oral agents or with insulin. The drug is also prescribed for children from ten years with type 2 diabetes mellitus as monotherapy or as part of a complex effect.
Contraindications
Medication "Metformin" (doctors' warnings about this) should not be taken with diabetic coma, precoma, ketoacidosis, hypersensitivity. Contraindications include acute conditions that develop with the likelihood of renal dysfunction. The drug is not recommended in a state of hypoxia, with dehydration, bronchopulmonary pathologies, lesions in the kidneys of an infectious nature, sepsis, shock, liver failure, with acute alcohol poisoning, lactic acidosis, including a history of it. The drug is not recommended for clinically expressed symptoms of chronic or acute pathologies that can provoke tissue hypoxia. Such conditions include acute heart attack, respiratory, heart failure, and others.
Do not prescribe medication under the age of ten years, subject to a
hypocaloric diet. Caution is shown in the treatment of elderly (over 60 years old) patients whose activity is associated with physical activity.
Side effects
The medicine “Metformin” (expert reviews indicate this) can provoke a loss of appetite, vomiting, nausea, taste disorders, diarrhea, rash, erythema, and other allergic skin manifestations. To improve gastrointestinal tolerance, it is recommended to slowly increase the dose. On the basis of therapy, pain in the abdomen, hepatitis, and abnormalities in the activity of the liver are observed. As a rule, when a medicine is canceled, these negative consequences go away. Against the background of prolonged use, hypovitaminosis B12, folic acid may develop.