People with various complaints come to the doctor for an appointment. Quite often this happens due to problems in the gastrointestinal tract. People in the bustle of modern time cease to monitor what they eat, as a result, suffer from diseases that were much less common before. Modern foods, fast food, as well as all kinds of chips and crackers contain a lot of food colors, additives and other negatively affecting the stomach ingredients. The result is gastritis or peptic ulcer. One of the commonly prescribed drugs for the treatment of gastrointestinal pathologies is the "Histak". Instructions for use, analogues and reviews about this drug will be discussed later.
How does the drug work?
Attached to each package of the drug "Histak" instructions for use. The photo below shows what the original packaging of the drug looks like.
The drug "Histak" refers to medicines that by their action provoke a decrease in the production of gastric juice, proportionally reducing the activity and amount of pepsin. The active substance of the drug - ranitidine - refers to blockers of histamine H2 receptors of parietal cells. It is able to suppress the secretion of acid in the glands of the stomach, reduces pain. The manifestation of heartburn and the frequency of its occurrence decreases significantly. The mucous membrane in the stomach activates its protective properties, heals ulcerative lesions, and the tone of the lower gastroesophageal sphincter normalizes.
The action of the drug "Histak" lasts for twelve hours. After you have taken the medicine, the maximum concentration of the active substance will be reached in just a couple of hours, and eating does not affect the absorption of the Histak drug.
Excretion of the drug from the body is carried out by the kidneys. A small part is allocated in the form of metabolic products, it is about 8%. About 40% is excreted in the urine if the drug is taken orally, and 70% if it is parenteral. The rest is excreted.
It is worth noting that with regular use of the drug at the prescribed dosage for 4-6 weeks, ulcers heal. And taking a maintenance dosage at night reduces relapse.
Who is prescribed the drug "Histak"
Instructions for use indicate diseases and conditions in which the drug is prescribed for treatment and prevention:
- Ulcerative lesions of various sections of the gastrointestinal tract.
- Ulcers that occurred in the postoperative period.
- For the treatment of reflux esophagitis and relieve symptoms of the disease.
- Gastroesophageal reflux.
- Zollinger-Ellison Syndrome.
- Epigastric or sternal pain.
- Bleeding in the stomach and intestines.
- Peptic, bleeding ulcers and repeated bleeding.
Also, the medication is used before anesthesia for patients who have a high risk of ejecting the acidic contents of the stomach.
Can everyone take the Histac? Instructions for use contain data on contraindications. Consider them below.
Who should not take the Histac
Before you start using any drug, you need to study the annotation. This also applies to the drug " Histak". Instructions for use of contraindications indicate the following:
- Hypersensitivity to any ingredient of the drug.
- Children under the age of twelve are not allowed to take the medicine.
- With great caution, a remedy is prescribed for patients with cirrhosis and renal failure.
Drug Therapy During Pregnancy and Lactation
When studying the active substance ranitidine, it was found that it is able to penetrate the placenta. During pregnancy for therapeutic purposes, the use of the drug did not adversely affect labor and the development of the fetus. The use of the Histak drug for pregnant women is possible, but if the necessary benefits exceed the potential risk to the fetus.
Also, the drug is able to enter (albeit in small quantities) into breast milk. At the time of treatment with “Histacom”, it is recommended to refrain from breastfeeding.
The following conclusion can be made: to prescribe the drug "Histak" pregnant and lactating is possible only in case of emergency.
Dosage and dosage form
The drug "Histak" is available in the form of tablets. They are white in color, slightly convex in shape, coated, marked on one side of the HISTAC 150, and on the other, the RANBAXY side. One tablet contains ranitidine hydrochloride 150 mg.
In order for the drug not to harm health, it is necessary to study the instructions for use before taking "Histak". The dosage of the drug is prescribed by the doctor, and can not be exceeded.
Tablets are prescribed for adults in the following dosage: 150 mg in the morning and evening. In the presence of a duodenal ulcer, a single dose of 300 mg at bedtime is possible.
The course of treatment for peptic ulcer is usually about 4 weeks. If no improvement occurs, then a repeat course is prescribed.
In case of recurrence of peptic ulcer, the medicine is prescribed as a prophylactic after the treatment course, as indicated by the "Histak" preparation instruction. Tablets should be taken once a day, at bedtime, in an amount of 150 mg. The prophylactic dose during the period of seasonal exacerbations of gastric diseases is also 150 mg per day.
Reflux esophagitis and erosive esophagitis often require a dosage increase of up to 150 mg four times a day. The treatment lasts up to two months.
Zollinger-Ellison syndrome also requires an increased dosage - 150 mg 3 times a day. If necessary, the dose can be increased. Studies have shown that patients taking 6 g of the drug per day (maximum dose) tolerated it well.
Before anesthesia is to be introduced, in order to prevent Mendelssohn’s syndrome, they take “Histak” - 150 mg a day before surgery, in the evening, and two hours before surgery.
Children can take the drug from the age of 12, while the dosage is based on body weight:
- Peptic ulcer - from 4 to 8 mg per kilogram of body weight per day.
- Gastroesophageal reflux - from 5 to 10 mg per kilogram of weight per day.
In the presence of pathologies in the work of the kidneys, the recommended dose is 150 mg per day.
Side effects of the drug
You need to know what may be undesirable effects when taking the drug "Histak". Instructions for use side effects of the drug describes the following:
- Leukopenia, agranulocytosis, recurrent thrombocytopenia.
- Allergic reactions.
- Drowsiness, irritability, increased fatigue, tinnitus.
- Headaches.
- Vasculitis, bradycardia, asystole.
- Diarrhea, constipation, dry mouth.
- Reversible hepatitis.
- Skin rashes.
- Acute nephritis, myalgia, discomfort in the mammary glands.
It should be noted that most often the drug is very well tolerated by patients. In case of side effects of the drug, a dosage reduction or refusal of the drug is necessary, and the body's functions will be restored.
Drug overdose
Do not exceed the recommended dose of the Histac drug. Instructions for use (the drug description is given above) warns of a possible overdose. In this case, an increase in side effects is possible. It is recommended to call a doctor. As an addition to treatment, hemodialysis is recommended.
How Histac interacts with other drugs and alcohol
The drug can reduce or increase its effectiveness, as well as neutralize the effect of certain drugs. One must be careful when taking “Histak” together with other drugs. Instructions for use indicate some features of the drug interaction:
- The action of "Histak" does not increase or decrease when the following drugs are used together: "Diazepam", "Lidocaine", "Theophylline".
- Prothrombin time was changed during joint treatment with coumarin anticoagulants. It is necessary to carefully monitor it.
- The simultaneous use of procainamide and its active metabolite with ranitidine can reduce their excretion. This will entail an increase in this substance in plasma.
- The absorption increases with the combined use with "Histak" of the following drugs: "Triazolam", "Midazolam", "Glipizid".
- The absorption of the following drugs is reduced: Delavirdin, Ketoconazole, Atazanavir, Gefitinib.
- Sucralfate in a dosage exceeding 2 g should be taken at intervals of 2 hours, so as not to reduce the effectiveness of ranitidine.
- Bone marrow inhibiting drugs increase the risk of neutropenia.
With the combined use of alcohol and "Histak", the level of alcohol in the blood rises. The effectiveness of the drug decreases with smoking.
Special instructions for the use of the drug
- When taking the drug "Histak" should refrain from work that requires increased attention, and the management of transport and mechanisms.
- At the beginning of treatment, it is necessary to examine and exclude gastric cancer, since this drug masks the symptoms. Prescribing medication to elderly patients and those with impaired renal function requires special attention.
- Elderly patients with existing medical conditions, such as diabetes, chronic lung disease, may develop pneumonia.
- The drug is prescribed with caution in patients with impaired liver function, since the “Histak” is metabolized in this organ.
Analogs of the drug "Histak"
For one reason or another, some patients are forced to take a drug with an identical composition. Analogs include:
- "Zoran."
- "Ranitidine."
- Zantak.
- "Atzilok".
- Ulran.
- "Ranitidine-Akos."
- "Ranitidine-Fereyn."
- "Ranitidine-Lect."
Before replacing the original with its analogue, you should consult with your doctor.
Reviews about the drug
The drug is very often prescribed by doctors for both prevention and treatment of gastric diseases. To achieve the desired therapeutic effect and prevent unwanted reactions before using the drug "Histak" instructions for use, reviews should be considered. So, patients note that the medicine is not included in the list of expensive, but it works very effectively.
Many say that they got rid of an ulcer with the help of this drug. The results are good, there were no side effects. In the medicine cabinet it is always worth keeping this medicine.
Patients use the drug for the treatment of gastritis and the results are also satisfied. There are practically no side effects. The drug is available. You can take it for prevention. As a result, the number of relapses of the disease is significantly reduced.
Do not take medications without consulting your doctor. This applies even to the most harmless at first glance. Health is the most precious thing a person has, take care of him.