Is Buspirone effective? Reviews who took this tool will be presented below. We will also tell you about the properties of this medication, in what cases it is prescribed, whether it has contraindications and side effects.
Form and composition of the drug
What is part of the drug "Buspirone"? Reviews of doctors say about such an active substance as buspirone hydrochloride. In addition, the medication contains additional components in the form of lactose, corn starch, calcium hydrogen phosphate dihydrate, sodium starch (type A), colloidal silicon dioxide, magnesium stearate and MCC.
This product is available in the form of white and round tablets, placed in a pack of cardboard.
Pharmacodynamic properties of the drug
What are the properties of the drug "Buspirone"? Instructions, reviews of doctors inform patients that this is an anxiolytic drug. It is intended for the treatment of anxiety conditions of various origins.
The exact mechanism of action of the tablets has not been established. However, experts argue that this drug is a selective agonist of postsynaptic 5-HT 1A receptors located in the nervous system.
After taking the drug, its effect is manifested gradually. The effect can be seen within one to two weeks. In this case, the maximum therapeutic effect is observed only after a month.
Pharmacokinetic properties of the drug
Where does the absorption of Buspirone take place? Reviews of experts indicate that this medication is quite quickly and almost completely absorbed from the digestive tract. The plasma concentration of the drug is observed after 1-1.5 hours. Communication with proteins is 95%, and the half-life is three hours.
Approximately 30-65% of the active ingredient and its metabolites are excreted in the urine during the day, and 20-40% are excreted along with feces. If the patient has problems with the liver and kidneys, their elimination is slightly reduced.
Indications for use of tablets
For what purpose can a drug such as Buspirone be prescribed? Reviews of doctors say that this drug is used in the presence of anxiety conditions, which are accompanied by symptoms such as stress, anxiety and increased anxiety.
Contraindications to the use of the drug
What conditions of the patient are forbidden to take Buspirone? Reviews of experts say that this drug should not be prescribed to people with hypersensitivity to the main and additional substances of the drug, malignant myasthenia, acute congestive glaucoma, severe renal failure, epilepsy and severe liver dysfunction.
In addition, the drug in question is contraindicated in childhood and during breastfeeding.
The drug "Buspirone": instructions for use
Reviews about this medicine will be presented a little further.
The instruction attached to the medication reports that its dose should be selected only by the attending physician, depending on the condition of the patient.
As a rule, at the very beginning of treatment, a medication is prescribed in the amount of five milligrams three times a day. Gradually, the specified dose is increased to 15-30 mg (distributed in several doses).
The maximum daily dosage should not exceed 45 mg, and a single dose should not exceed 30 mg.
How should I take buspirone? The instruction says that taking the tablets should be daily at the same time. They can not be chewed. The drug should only be washed down with a small amount of water.
People with impaired kidney or liver function should take the lowest possible dosage.
The duration of the course is determined individually (for each case separately). It is forbidden to take the drug for a long time, especially without the supervision of a doctor.
In parallel with treatment, it is recommended to conduct sociotherapeutic and psychotherapeutic measures.
Overdose cases
What are the signs of an overdose when taking elevated doses of Buspirone? Reviews of experts speak of the following manifestations: miosis, nausea, fatigue, dizziness, disturbances in the stomach, and vomiting.
In case of an overdose, gastric lavage is carried out, as well as monitoring of blood pressure, respiration and pulse. Treatment is symptomatic.
Side effects
Does Buspirone Sandoz cause side effects? The reviews of patients and doctors indicate that this medication can lead to the appearance of a fairly large number of adverse events:
- myocardial infarction, temporary loss of consciousness, heart failure, nonspecific chest pain, cerebrovascular accident, tachycardia, bradycardia, arterial hypotension or hypertension, cardiomyopathy;
- conjunctivitis, blurred vision, a feeling of pressure in the eyes, redness of proteins, pain in the eyes, narrowing of the field of vision, itching, photophobia;
- irritability, anxiety, impaired coordination, nightmares, extrapyramidal disturbances, insomnia, spontaneous movements, nervousness, tremor, emotional arousal, impaired tone, hostility, memory impairment, depression, illegible speech, drowsiness, serotonin syndrome, dizziness, numbness, decreased attention, stupor, confusion, mood swings, depersonalization, claustrophobia, sensitivity to sounds, fever, hyperkinesia, impaired associative perception, apathy, euphoria, hallucinations nation, suicidal thoughts, paresthesias, seizures, parkinsonism, discomfort, lethargy, psychosis, akathisia;
- frequent urination, urinary retention, nocturnal urination, enuresis;
- nosebleeds, nasal congestion, rapid breathing, sore throat, shortness of breath, compression in the heart;
- arthralgia, stiffness and muscle spasm, myasthenia gravis, myalgia;
- changes in blood counts;
- cold hyperesthesia, asthenia, a tendency to excessive alcohol consumption, headache, impaired blood coagulation, weight gain or decrease, hot flashes, ringing in the head, hyperhidrosis, malaise, fatigue, impaired taste and smell, voice loss, hiccups, glossalgia;
- noise in ears;
- menstrual irregularities, decreased or increased libido, inflammation of the genitourinary organs, amenorrhea, impotence, decreased ejaculation;
- acne, edema, ecchymosis, hyperemia, pemphigus, alopecia, dryness, eczema, allergic manifestations, urticaria, thinning of nails, hematomas;
- diarrhea, irritable bowel syndrome, hypersalivation, nausea, blood discharge from the rectum, pain in the epigastric region, increased liver enzymes, xerostomia, constipation, flatulence, increased or decreased feeling of hunger, vomiting;
- galactorrhea, thyroid dysfunction, gynecomastia.
Drug interaction
Before using the drug "Buspirone", be sure to read the instructions. It provides the following information about the drug interaction of the medication mentioned:
- When combined with antidepressants, antihypertensive drugs, cardiac glycosides, anticoagulants, hypoglycemic and antipsychotics, as well as with oral contraceptives, strict medical supervision is required. Interaction with sedatives and benzodiazepines is unacceptable.
- Strong cytochrome P450 inhibitors increase the bioavailability of Buspirone.
- It is not recommended to take the drug with MAO inhibitors because of the possible occurrence of a hypertensive crisis.
- When taken with Cimetidine, the maximum concentration of Buspirone Sandoz is increased by 40%.
- "Rifampicin" reduces the maximum concentration of the drug by approximately 89.6%.
- When combined with medications that affect the maximum concentration of Buspirone, it is advisable to adjust the dose of the latter.
- "Ritonavir" and "Ketoconazole" block the biological transformation of "Buspirone", and also increase its plasma concentration.
- When the drug is combined with Diazepam, the content of the latter in blood plasma may increase. In addition, side effects such as nausea, dizziness, and headache may appear.
- The simultaneous administration of "Buspirone" with "Haloperidol" can increase its level in blood serum.
- You should refrain from drinking alcohol during treatment with “Buspirone Sandoz”.
The drug "Buspirone": reviews of people (consumers) and specialists
Most patients leave positive reviews about this drug. They note its high efficiency. Side effects have been reported extremely rarely.
Experts say that taking such pills does not very often cause undesirable effects. They can be observed only in a separate category of patients. In this case, side effects are manifested only in a mild form and pass quite quickly without discontinuation of the drug.