What is the preparation "Tyrosol" intended for? Instructions for use of this medication, its side effects and indications will be presented in detail in this article. In addition, we will tell you about whether this remedy has contraindications for use, in what form it is produced, what analogues exist, and so on.
The form of release of the drug and its composition
In what form does the drug “Tyrosol” go on sale? Instructions for use of this tool are always contained in the package with the medicine.
Currently, the presented medication is available only in the form of round tablets of light yellow color (covered with a film coating). This drug includes such an active substance as tiamazole. In addition to it, tablets also contain auxiliary components (sodium carboxymethyl starch, dimethicone 100, colloidal silicon dioxide, hypromellose, lactose monohydrate, magnesium stearate, cellulose powder, talc, hypromellose, corn starch, titanium dioxide, macrogol 400, yellow iron oxide).
Pharmacological properties of the drug
How does the drug "Tyrosol"? Instructions for use contain a lot of information on this subject. We will also consider it in the presented article.
The active substance of this drug is able to act on the thyroid gland, inhibiting the production of its hormones by blocking enzymes (for example, peroxidase, which is involved in the iodination of tyrone).
After taking the drug in a patient, the following changes are observed:
- acceleration of the excretion of iodides from the thyroid gland and a decrease in basic metabolism;
- increased activation of the secretion and synthesis of thyroid - stimulating hormone by the pituitary gland (may be accompanied by a barely noticeable increase in the size of the thyroid gland).
It should also be noted that the treatment of thyrotoxicosis with “Tyrosol” is very effective, especially with symptomatic therapy.
After a single dose of tablets, their duration is about a day.
Indications for use of the drug
In what cases can a Tyrozole medication be prescribed by a doctor? The instruction that is attached to this drug contains a list of the following indications:
- preparation for the treatment of thyrotoxicosis with radioactive iodine;
- thyrotoxicosis disease;
- therapy in the latent period of the action of radioactive iodine (carried out before the action of the substance in question for 4-6 months);
- preparation for surgical treatment of thyrotoxicosis (surgery);
- prevention of the disease after the administration of iodine preparations (including after taking radiopaque iodine-containing agents) if the patient has latent thyrotoxicosis, autonomous adenoma, or a history of thyrotoxicosis.
It is impossible not to mention that in exceptional cases, the drug under consideration is used for long-term maintenance therapy of hyperthyroidism. As a rule, this happens when there is no way to perform a radical treatment of the patient (for individual reasons or in connection with the general condition of the patient).
Contraindications to the use of the medication
Are there any conditions or pathologies in which it is forbidden to take the drug "Tyrosol"? The instruction of the drug gives an exhaustive answer to this question. It indicates the following contraindications for use:
- hypersensitivity of the patient to such an active substance as tiamazole and thiourea derivatives;
- granulocytopenia, especially in the anamnesis;
- agranulocytosis in the period of previous treatment with thiamazole or carbimazole;
- cholestasis, manifested before the immediate start of therapy;
- treatment with thiamozole in combination with Levothyroxine medication during pregnancy.
It should also be noted that the funds presented have relative contraindications. These include previously observed skin allergic reactions to thiourea derivatives.
In addition, the medication should be used with extreme caution to those patients who have very large goiter, accompanied by a narrowing of the trachea. In this case, the patient is prescribed only short-term therapy during preparation for surgery. It is also necessary to say that tablets "Tyrosol" should be taken with caution in patients with liver failure. To prescribe a safe dosage of the drug, patients should always consult an experienced doctor.
Medication "Tyrosol" and pregnancy
Few people know about this, but during pregnancy you can take this drug. However, this should be done very carefully and only under the supervision of a physician.
According to experts, the lack of proper treatment for such an abnormality as hyperfunction of the thyroid gland during pregnancy can adversely affect the development of the fetus. Moreover, ignoring the disease will lead to serious complications (premature birth, various deviations in the child, etc.).
Many women are interested in: “Tyrozole” means a hormonal drug or not? The answer to this question is obvious. This medication is hormonal. It should be noted that it quickly penetrates the placental barrier. Moreover, in the blood of the fetus, it can reach the same concentration as that of the expectant mother.
Due to the fact that the influence of the active component (tiamazole) on the developing intrauterine organism cannot be completely ruled out, hormone pills for pregnant women should be prescribed only after a full assessment of the risk and the benefits of its use, in minimally effective dosages, without the additional use of the drug “Levothyroxine”.
The danger of using the drug "Tyrosol" during pregnancy
Every woman who has obvious problems with the thyroid gland should know how to take "Tyrosol" during the period of gestation. This fact is due to the fact that the dosage of this drug, significantly exceeding the recommended, can cause hypothyroidism and goiter formation in the unborn baby, as well as contribute to low birth weight.
Lactation
Is it possible to take the drug “Tyrosol” during breastfeeding? Analogues of this tool, as well as the original itself, to use during lactation is not recommended. Why?
Due to the fact that the active substance tiamazole penetrates into breast milk quite quickly and is able to reach concentrations in it that correspond to that in the blood of a young mother, a newborn baby may develop such a deviation as hypothyroidism. In this regard, if it is necessary to continue the treatment of thyrotoxicosis during breastfeeding, the presented drug should be used in reduced dosages (up to 10 mg in fact) without additional prescription of the drug Levothyroxine.
The drug "Tyrosol": instructions for use
If the doctor prescribes this drug to the patient, he is obliged to consult the patient about the features of its use. As a rule, the medicine is taken only after eating food. At the very beginning of therapy, experts recommend using the medication at a strictly defined time.
During treatment of thyrotoxicosis, patients are usually prescribed 2-4 tablets of the drug per day (10 mg each). In this case, the duration of therapy should be at least 6 weeks.
After the thyroid function was fully or partially restored, doctors recommend switching to a maintenance dose. In this case, patients need to take 5-20 mg of the drug per day (simultaneously with the Levothyroxine medication).
In the period of preparation for thyrotoxicosis therapy with radioactive iodine, as well as for surgical intervention, patients are prescribed the same dosage as with the usual treatment of the disease (up to the euthyroid state). After this, patients are additionally prescribed Levothyroxine medication, beta-blockers and iodine preparations.
In the treatment that is carried out before the onset of exposure to radioactive iodine, patients are prescribed a dosage equal to 1-4 tablets (5 mg each). This medication should be administered within a month.
During long-term therapy (supportive), the dosage of the medication, according to the instructions, is from 1.25 to 10 mg per day. At the same time, a small dose of Levothyroxine is prescribed.
For the preventive purposes of the development of thyrotoxicosis during the period of taking iodine preparations, the Tyrozole medication is very effective in the following dosage: from 10 to 20 mg per day.
As a rule, for children, this drug is prescribed based on body weight. Usually, as an initial dosage, the drug is prescribed in an amount of 0.3-0.5 mg. If maintenance therapy is needed, then the child should take 0.2-0.3 mg of the drug. Moreover, Levothyroxine is prescribed only in case of urgent need.
The maximum single dose for adults is 10 ml, and the daily dose is 60 ml. The duration of the medication we are considering can be increased to 1.5-2 years (depending on the course of the disease). If therapy was interrupted, then until the patient recovers completely, he may develop a relapse of the disease.
In rare cases, after the end of taking the medicine, a person may experience late hypothyroidism, which is not a side effect, but is associated only with inflammatory and destructive processes that occur in the tissues of the thyroid gland.
Overdose cases
The drug "Tyrosol" and weight gain: what is the relationship between them? Due to the fact that this drug is hormonal, it can directly affect the patient's weight. However, most experts argue the opposite. According to them, the Tyrosol medication and weight gain are not interconnected things. Indeed, the mass of a person diagnosed with thyrotoxicosis increases only due to the presence of the disease itself. Moreover, the deviations themselves can cause severe swelling on the face and limbs. In this case, you should consult a specialist and take tests for hormones.
If the patient was prescribed the medication mentioned, then he needs to know about the method of its use. Indeed, in case of an overdose of the drug, the thyroid gland may increase in the patient, as well as a deviation such as hypothyroidism. In these situations, the medicine is urgently canceled.
By the way, in high doses (more than 120 mg per day), this remedy easily leads to the occurrence of myelotoxic effects.
Side effects after taking the medication
What reactions can appear after the use of tablets "Tyrosol"? Side effects of this drug are described in each instruction. We will talk about them in more detail in this section of the article.
In most cases, the drug is well tolerated by patients. However, it should be noted that sometimes while taking the medication, people may develop allergic reactions to the skin (in the form of itching, redness and rashes) and arthralgia, in addition, in rare cases, dizziness, weakness and vomiting can occur.
What other negative consequences can the drug “Tyrosol” provoke? Side effects, reviews about this medication are presented in this section of the article. So, we are talking about such unpleasant reactions:
- generalized lymphadenopathy;
- thrombocytopenia;
- neuritis;
- temperature rise;
- cholestatic jaundice, toxic hepatitis and arthralgia (develop very slowly);
- autoimmune syndrome in conjunction with hypoglycemia;
- marked increase in the glands of the salivary;
- pancytopenia;
- lupus-like reaction;
- change in taste sensations of a reversible nature;
- agranulocytosis (manifests itself immediately or several months after the start of therapy, which leads to the need to cancel the drug);
- polyneuropathy.
According to the reviews of those patients who take or have ever taken this medication, it can easily provoke an increase in body weight. As a rule, such a negative effect occurs after taking large doses of the drug.
In what cases should you stop taking the drug?
Now you know how the drug "Tyrosol" can affect the human body. Side effects in which you should immediately stop taking the drug are as follows:
- severe weakness;
- generalized skin rash and itching;
- difficulty swallowing;
- jaundice;
- sore throat;
- prolonged nausea or vomiting;
- subcutaneous hemorrhage or bleeding of unknown origin;
- signs of furunculosis or stomatitis;
- severe pain in the epigastrium.
Drug interaction
The drug “Tyrosol” (price is indicated below) produces a stronger effect with iodine deficiency, as well as while taking such drugs as “Lithium”, “Gentamicin”, “Reserpi”, “Amiodarone” and beta-blockers.
With therapy with this drug, the risk of developing leukopenia increases if sulfanilamides and metamizole sodium are taken together , and decreases with the use of folic acid and leucogen.
To date, there is no data on the effect of other drugs on the pharmacodynamics and pharmacokinetics of the presented drug. However, it should be remembered that with thyrotoxicosis in a patient, elimination and metabolism of substances are accelerated. In this regard, in some cases, mandatory dose adjustment of other drugs is required.
Simultaneous intake of alcoholic beverages and the drug "Tyrosol"
How do the drug "Tyrosol" and alcohol interact, are they compatible or not? By asking such a question to any specialist, you will immediately receive a definite answer.
The fact is that alcohol helps stimulate the brain and nervous system, regardless of whether a person is healthy or sick. After the joint administration of the drug and alcohol, a synergistic effect takes place, which helps to enhance the negative effect of the substances on the body. As a result, additional side effects occur and pathological processes are stimulated.
That is why patients should remember that until the completion of drug treatment of thyroid diseases (as, indeed, any other) and achieving the desired result, there can be no talk of any alcoholic beverages.
Analogues of a medical product, reviews about the drug, its price and storage conditions
Now you know what the drug "Tyrosol" is. The price of this drug may vary slightly depending on the margin of pharmacy chains. The average cost of such a medicine is about 200 Russian rubles for 50 tablets.
What to do if for some reason you were not able to purchase the drug "Tyrosol"? Analogs of it (for the active substance) are always available in the pharmacy. Among them, I would like to especially highlight the following drugs: Merkazolil, Tiamazol, Metizol and Tiamazol-Filofarm. The price of these funds is similar to the above (in some pharmacies may vary slightly).
Important! According to the attached instructions, this medication belongs to a number of antithyroid medications. In this regard, the medicine is dispensed only according to the prescription form, on which there is a personal seal of the attending physician.
Judging by the reviews of patients, this tool is quite effective. But this is only on condition that if you take it at the dosages that were prescribed by the doctor. In no case do not self-medicate and dose adjustment at your own discretion - this is fraught with serious trouble. In order not to be unfounded, we give a few generalized comments of patients who have experienced this tool on themselves.
Often people complain of hair loss, discomfort in the pancreas, allergic reactions (severe itching and soreness of the skin) that appear after a few weeks of taking the drug “Tyrosol”. Some patients mention an increase in heart rate. Satisfied many complaints come to nausea and pain in the stomach. Once again, we recall that with the development of negative reactions, you should stop taking the drug and consult a doctor.
It is advisable to store the medication in a dark place where direct sunlight does not fall. The shelf life of the tablets is no more than 4 years.