The drug "Fosfomycin" is available in the form of granules for the manufacture of a solution for oral administration, as well as for iv administration. The medicine has a wide range of antimicrobial effects. The antibiotic "Fosfomycin" has a bactericidal effect, suppressing the first stage of synthesis in the cell wall of pathogenic microorganisms. The medication has a high absorption rate from the digestive tract. After two to two and a half hours, the content of the product reaches its maximum level.
The bioavailability of the drug is 34-65%. The drug is not exposed to metabolism, does not bind to plasma proteins. It is excreted mainly in unchanged form with urine. A small amount (about 10%) leaves through the intestines.
Indications
The drug “Fosfomycin” recommends the use of the drug for bacterial cystitis, acute relapses, nonspecific urethritis, and massive asymptomatic bacteriuria in pregnant women. Indications include postoperative infectious lesions of the urinary tract (elimination and prevention against the background of transurethral diagnostic measures, surgical interventions).
Contraindications
The medication "Fosfomycin" (instructions for use warns about this) is not recommended for intolerance. During lactation or during pregnancy, the medicine is prescribed solely in accordance with vital indications and under the supervision of a specialist. Nursing patients are advised to stop feeding for the duration of therapy.
Dosage regimen
The drug is taken orally. To prepare the solution, the granules should be dissolved in 1/3 tbsp. water. The medicine is drunk once a day. It is advisable to use the medicine "Fosfomycin" (instructions for use indicate this) on an empty stomach, at bedtime and after emptying the bladder. Doses for adults - a bag once a day. For prevention during surgical interventions and diagnostic procedures, the dosage remains the same, while the drug is drunk three hours before the interventions and a day after. For children from 5 to 18 years, 2 g is recommended once a day. The duration of therapy is one day. In severe or recurrent course of the pathology, the drug is taken again after a day. Because of renal failure, the interval between doses is increased. An intravenous dosage regimen is established by a specialist.
Means "Fosfomycin." Instructions for use. Adverse reactions
When taking the medication, it is likely that an gastrointestinal upset, allergic reaction, nausea or vomiting, skin rash.
additional information
With an overdose, diarrhea develops. When signs of poisoning appear, symptomatic treatment is indicated. As practice shows, the likelihood of an overdose is unlikely. When taking the medication, the simultaneous use of Metoclopramide, which reduces the concentration of the drug in serum, should be excluded. Caution during therapy should be observed with diabetes. If adverse reactions not described in the annotation appear, you should visit a doctor.