Diseases of the nervous system are widespread in our country. For their treatment, there are many drugs. One such medicine is the Serenate medication. The instruction notes that before using the drug, a doctor’s consultation is mandatory.
The composition and form of release of the drug
It is produced in the form of film-coated tablets, the drug "Serenata". The instruction fully describes the composition of the medication, which includes the active substance of sertraline hydrochloride. As additional elements were involved:
- microcrystalline cellulose;
- sodium carboxymethyl starch;
- anhydrous calcium hydrogen phosphate;
- hyprolosis;
- magnesium stearate;
- polysorbate.
The tablet shell consists of hypromellose, titanium dioxide and propylene glycol.
The medicine is produced in tablets of 50 mg and 100 mg. They are a biconvex capsular shape. They are white and at risk on the one hand. Packed in 10 tablets in an aluminum blister. In a cardboard pack can be from 3 to 5 blisters, plus instructions for use.
The medicine is stored at a temperature not exceeding 25 ° C. The drug should be in a place protected from the sun and out of the reach of children. The shelf life of the drug is three years from the date of manufacture of the drug. Do not take pills after this period.
The medicine is dispensed from pharmacies only by prescription. A medicine is made in India.
Pharmacological features of the drug
The drug "Serenata" (instructions for use are sold with tablets and must be carefully studied before use) refers to antidepressants. It acts as a strong selective serotonin reuptake inhibitor. To a small extent, it affects the reuptake of dopamine and norepinephrine. If the drug is used in therapeutic doses, the active substance of the drug inhibits the uptake of serotonin in the platelets of the human body.
As a result of clinical trials, it was noted that the drug does not have a sedative, stimulating and anticholinergic effect. During the administration of tablets, no psychomotor disturbances were observed in the subjects.
The medication is not addictive and does not affect body weight, even with prolonged use of tablets.
Animal tests have shown that sertraline does not increase catecholamine activity. Not characterized by affinity for serotonergic, muscarinic, histaminergic, dopaminergic, GABA-, benzodiazepine and adrenergic receptors. It is noted that Serenata tablets do not have a cardiotoxic property.
Prolonged use of the drug in animals was used to stabilize the noradrenaline receptors that are located in the brain and are of the type of negative feedback. It is this action that is characteristic of many anti-obsessive drugs and antidepressants.
Serenat tablets (the instructions completely describe the method of taking the medicine and advise on the recommended dosage) are not addictive, so patients do not abuse them.
When should medicine be used?
The drug "Serenata" instruction advises to use for prolonged depressive states. The medicine is prescribed to prevent depression of various etiologies. The prescription for the use of tablets are obsessive-compulsive disorders that occur both in the adult population and in children from six years old. Prescribe medication for panic disorders, which may be accompanied by agoraphobia. Use pills for stress that has arisen as a result of a trauma. Indication for use is social anxiety disorder, which is also called social phobia.
Contraindications
The drug "Serenata" instruction for use does not recommend taking with hypersensitivity to sertraline and additional elements that make up the medication. Do not prescribe medication for children under six years of age, this applies to obsessive-compulsive disorders. In all other cases, the drug "Serenata" (tablets) is not prescribed until eighteen years of age.
It is forbidden to use sertraline simultaneously with monoamine oxidase inhibitors. In this case, there is a risk of serotonin syndrome, which can manifest as agitation, hyperthermia, as well as tremor of the extremities.
Treatment with tablets should begin after two weeks, after stopping monoamine oxidase inhibitors. Reception of “Serenata” must be stopped at least seven hours before the start of treatment of irreversible MAOI. It is forbidden to use the drug simultaneously with pimozide, tryptophan or fenfluramine.
Caution is necessary to use sertraline in patients suffering from organic brain pathologies, epilepsy, renal and liver failure. Having a pronounced weight loss. You should be careful when using sertraline with medications that increase serotonergic neurotransmission. This also applies to those drugs that affect platelets.
Patients taking tricyclic antidepressants and sertraline at the same time should be closely monitored.
The drug is forbidden to use during pregnancy and lactation.
Serenata medicine: instruction for use
Reviews (analogues are not always able to act as effectively as this medicine) note that tablets rarely cause side effects. Take the drug only orally, once a day, regardless of food intake, with a small amount of water.
For depression and obsessive-compulsive disorders, treatment begins with 50 mg per day. If panic disorder occurs, social phobia and a post-traumatic state of stress occur, then therapy is started with 25 mg per day. After a week, the dosage is increased to 50 mg per day. This use of the drug can reduce the occurrence of side effects at the first stage of treatment.
The dosage is selected with a gradual weekly increase. If the treatment is normal, 50 mg per day does not give any result, then the dose is increased by another 50 mg, but not more than once a week. The maximum daily dosage is 200 mg per day.
Within a week, the first results of treatment appear, but the full effect can be achieved after 2-4 weeks of continuous therapy. With obsessive-compulsive disorders, a longer medication is acceptable.
With maintenance treatment, the dosage should be minimally effective. In this case, it is adjusted depending on the therapeutic effect. If prolonged depression is observed, then the drug is taken for at least six months.
The patient should be constantly monitored for panic and obsessive-compulsive disorders. In this situation, relapse prevention is not carried out.
Serenata tablets (instructions for use indicate the conditions in which this drug cannot be used) is allowed to be used to treat obsessive-compulsive disorders in children from six years of age.
Adolescents, in the age category of thirteen to seventeen years, are prescribed an initial dosage of 50 mg per day. The initial dose for children from six to twelve years is 25 mg per day. After seven days of using the drug, the dosage can be increased to 50 mg. In the future, if therapy fails, the amount of the drug is increased by another 50 mg. An increase in dosage is carried out once every few weeks. The maximum allowable amount of the drug is 200 mg per day. The dose is changed no more than once every seven days.
When treating patients of the age group from six to eighteen years old, one should pay attention to body weight in order to avoid overdose symptoms.
The drug "Serenata" instructions for use does not recommend taking patients with impaired liver function. Patients with renal failure require dose adjustment.
Do not abruptly stop taking pills. If you need to stop therapy, then this should be done gradually, over fourteen days. Only in this case, the likelihood of withdrawal will be minimized. If withdrawal occurs, you should consult a doctor to prescribe the appropriate treatment.
Negative body reactions
Warns that with prolonged use, the drug "Serenata" can cause negative reactions of the body, instructions for use. Analogs in this case are able to replace the specified drug.
Among the side effects of the gastrointestinal system, dry mouth can occur. There was a decrease in appetite, which in isolated cases led to anorexia. Among the negative reactions there were dyspeptic disorders, including flatulence, vomiting, nausea, diarrhea, and abdominal pain.
In some cases, with prolonged use of tablets, an increased activity of transaminases in the blood was recorded. After drug withdrawal, this indicator returns to normal.
From the nervous system, patients were worried about drowsiness, dizziness, headache, tremor of the extremities. Patients complained of insomnia, agitation, the occurrence of feelings of anxiety, hypomania, impaired coordination of movement and insecure gait. Some felt weakness, extrapyramidal disorders.
There was dyskinesia, cramps in muscle tissue, a malfunction of the visual apparatus. Such disorders were most often found in patients who had a history of these pathologies or acquired them due to the simultaneous use of antipsychotic drugs.
When taking the drug there were malfunctions in the endocrine system. They were expressed in the disorder of ejaculation, decreased sexual desire, menstruation, galactorrhea and hyperprolactinemia.
In some cases, the drug "Serenata" (antidepressant) caused increased sweating. Sometimes, due to its effect on the body, weight loss occurred, which in isolated cases turned into anorexia. There are people who were worried about transient hyponatremia during treatment.
Among dermatological symptoms, redness of the skin, rashes, and itching are noted. In rare cases, erythema multiforme was observed.
special instructions
Notifies that they do not prescribe Serenata medication and instructions for use for two weeks after the cancellation of MAO inhibitors (reviews note that the drug will help to survive depression and relieve anxiety). At the same time, MAO inhibitors are not recommended for taking within fourteen days after discontinuation of sertraline therapy. There are insufficient studies on the use of the drug in patients undergoing electroconvulsive therapy.
It is believed that patients who are depressed can always resort to suicide. A similar risk persists until complete remission is achieved. Therefore, at the time of depression, the patient should be closely monitored by medical personnel.
Particular care should be taken with the complex use of Serenate tablets and drugs that are depressing to the central nervous system. In this situation, the patient should be monitored.
During Serenata therapy, it should be remembered that the simultaneous use of this medicine with any MAO inhibitors can lead to the most serious consequences and cause the progression of various complications, including serotonin syndrome.
Similar negative reactions of the body in isolated cases were fatal, occurred when using MAO inhibitors during treatment with antidepressants, which inhibit the neuronal uptake of monoamines. Side effects also occur after the withdrawal of these drugs.
From the complex use of selective inhibitors that perform neuronal reuptake of serotonin, rigidity, excessive irritability, hyperthermia, myoclonus, changes in mental status, mental confusion, agitation can develop. The combination of sertraline and coumarin causes an increase in the prothrombin period. Particular attention when taking the drug should be given to children from six years.
Warns that it is strictly forbidden to drink alcohol when using the drug "Serenata", instructions (reviews note that tablets can negatively affect vision).
When using sertraline, there are no failures in the work of psychomotor functions. Despite this, co-administration with other medications can cause impaired concentration of attention and a failure in coordination of movements. Because of this, it is not recommended to drive vehicles and engage in activities requiring increased concentration of attention during Serenata therapy.
The cost of the drug
You can buy Serenata tablets (antidepressant) in almost every pharmacy with a doctor’s prescription. Reviews of patients note that the drug is capable of causing headache and insomnia, as well as disturbances in the gastrointestinal tract. The cost of 30 tablets of 50 mg is 600 rubles. The price of 30 tablets of 100 mg varies in the region of one thousand rubles.
The drug "Serenate": analogues
If the drug for some reason did not fit, then the doctor prescribes analogues instead. The most common structural substitutes include:
- "Zoloft";
- "Stimuloton";
- "Depre default";
- "Aleval";
- Lustral;
- Asentra;
- "Serlift";
- Thorin
- Mistral
- Misol;
- Seralin;
- "Zalox";
- Sertiva;
- Zosert.
These and other drugs can replace the Serenata drug. Analogs should not be selected independently, without consulting a doctor, as this approach can harm health and cause a number of side effects.
Patient Reviews About Pills
The medicine "Serenata" (antidepressant) customer reviews caused a variety of different. Some patients are completely satisfied with the effect of this drug. They say that the effect after its use is observed already on the first day of treatment, and by the end of the week the result becomes more pronounced. They note that the medication is a mild antidepressant. It cheers up, gives peace and awakens the craving for life. After its use, depression, anxiety, fear and suspiciousness go away.
The medicine helps to cure mild neurosis. Removes panic. Patients note that the tablets are well tolerated and rarely cause negative effects. They can be drunk for a long period, but under the supervision of a doctor. The drug significantly improves mood, helps to cope with depression. Removes fear, panic. Helps to feel the craving for life.
But the Serenate medicine does not always give the expected result. Reviews of these people note a complete loss of appetite, headache, sleep disturbance. Some patients note that the drug negatively affects vision. May cause confusion and lack of coordination. Some patients had suicidal thoughts. There are people who, after consuming these pills, complained of increased depression and anxiety. It was noted that the drug is able to create internal discomfort.
Doctors often use this tool in their practice. According to them, this medicine belongs to the inhibiting antidepressants. May increase anxiety and aggravate anxiety depression. In the latter case, doctors recommend giving preference to antidepressants with a sedative effect. They remind their patients that the selection of an antidepressant is carried out individually for each patient, and what helped one may be completely useless for another.