Anyone who has experienced a prolonged gag reflex and nausea will not want anyone to experience such feelings. It is with a short vomiting that the body is cleansed of everything unnecessary, but if it becomes prolonged, the situation threatens with complete dehydration. Instructions for use "Metoproclamide" claims that the drug is able to stop this symptom and greatly facilitate well-being. It begins to act within a few minutes after application.
Means "Metoproclamide": release form and composition
The drug has two forms of release. These are tablets and injection solution. Fast and effective Metoproclamide. The composition of the drug in tablets includes the active substance metoclopramide hydrochloride in an amount of 10 mg. As additional elements used in the creation of the pill, lactose, corn starch, talc, sodium starch glycolate, magnesium stearate, colloidal anhydrous silicon are isolated.
In 1 ml of solution for injection contains about 5 mg of metoclopramide hydrochloride. Auxiliary components are disodium ethylenediaminetetraacetic acid, sodium acetate, sodium metabisulfite, acetic acid and water for injection.
Tablets are packaged in aluminum blisters of ten pieces. The cardboard packaging contains 50 or 100 tablets, as well as instructions for the use of “Metoproclamide”. Inside, the injection preparation is poured into 2 ml ampoules. The box can contain 5 or 10 glass ampoules.
Pharmacological effect of the drug on the body
Instructions for use "Metoproclamide" describes in detail all the subtleties of taking and exposure to the drug. The drug itself refers to antiemetic drugs. It has a direct effect on reducing nausea, vomiting and hiccups. Activates gastrointestinal motility. The antiemetic effect of the drug is associated with inhibition of dopamine D2 receptors and an increase in the index of trigger region chemoreceptors. The drug belongs to blockers of serotonin receptors. It removes the tone of the smooth muscles of the gastric organ and increases its cholinergic reflexes. The drug promotes the emptying of the stomach, as it does not allow the walls of the gastric organ to relax and stimulates its antrum part, the upper region of the small intestine. Reduces the reaction of food in the esophagus by increasing the pressure of the sphincter of the esophagus in a relatively calm state. Increases the clearance of stomach acid due to increased peristalsis.
Also, Metoclopramide activates prolactin production and provokes a transient increase in circulating aldosterone. A similar picture can cause temporary fluid retention in the body.
Accepted tablets are absorbed from the gastrointestinal tract in a short time. Combine with blood proteins by 30%. Biotransformed in the liver. The body secretes the active substance in unchanged form and in the form of metabolites by the kidneys. The half-life of the drug is from four to six hours.
"Metoproclamide": indications for use and contraindications
The drug is quite serious, it can not be used without a doctor's prescription. As a rule, the drug is used for nausea, vomiting, hiccups, provoked by various situations. It is prescribed for atony and hypotension of the gastrointestinal environment, including the postoperative, the drug "Metoproclamide". Indications for use note that the drug is effective in the treatment of biliary dyskinesia belonging to the hypomotor class. It is recommended to drink tablets for reflux esophagitis, functional pyloric stenosis and flatulence. The drug is involved in the complex treatment of stomach ulcers and duodenal ulcer, which are in the acute stage. The medicine increases the motility of the gastrointestinal tract during x-ray studies. The tool alleviates the condition with duodenal sounding. Here it enhances the movement of absorbed food through the small intestine and in every possible way contributes to faster emptying.
Warns that it is impossible to accept to people with hypersensitivity to the active substance and its auxiliary components, the drug "Metoproclamide", instructions for use. In ampoules and tablets, the medicine is not allowed to persons who underwent surgery on the organs of the gastrointestinal tract.
Specialists with extreme caution advise the drug to patients with bronchial asthma, having arterial hypertension and suffering from Parkinson's disease. Carefully use the medicine for patients with kidney or liver failure, as well as children and the elderly over the age of 65.
Dosage and recommended doses
The drug “Metoproclamide” can be used both orally and in injection form. Instructions for use of the tablet advises adults to drink 5-10 mg 3-4 times a day half an hour before a meal, drinking dragee with water.
If there is a strong vomiting reflex and nausea, then the drug is injected into the muscle area or intravenously in an amount of 10-20 mg. Also, the medicine can be administered intranasally at 10-20 mg in each nasal passage 2-3 times a day. The maximum dose that can be taken or administered to the patient at a time is 20 mg, the daily dose is 60 mg.
The average single dose for children over 6 years of age is 5 mg of Metoproclamide. Instructions for use recommend in this case to use the drug 1-3 times a day. The method of administration here may be either oral or parenteral.
Up to six years, children, as a rule, the drug is prescribed for the parenteral method of administration in an amount of 0.5-1 mg / kg. The regularity of admission is 1-3 times a day.
To prevent vomiting and in the treatment of vomiting reflex (nausea) when taking cytostatics or during radiation therapy, Metoclopramide is used at a dosage of 2 mg per kilogram of weight. The procedure for administering the drug is carried out 30 minutes before irradiation or the use of cytostatics. If necessary, the injection solution is administered again after two hours.
If there is an x-ray study for adults, then the drug is injected into a vein in an amount of 10-20 mg fifteen minutes before the procedure. Patients with renal-hepatic insufficiency should start taking it from the norm, which is twice less than the recommended one. The next injection of the drug is affected by the patient's condition and his reaction to the drug.
Side effects
Warns that side effects may occur after taking the drug "Metoproclamide", instructions for use. These are disorders of the digestive system, including diarrhea, constipation, and dry mouth. Disruptions in the use of this drug can be from the central nervous system. This feeling of fatigue, headache, drowsiness, depression, dizziness and akathisia. Extrapyramidal reactions may be present in children, as well as in young people. In some cases, spastic torticollis, spasm of the muscles of the face, hyperkinesis are observed. When using the drug, agranulocytosis may occur. Galactorrhea, malfunctions of the menstrual cycle, gynecomastia are quite rare. Some patients are concerned about skin rashes.
special instructions
Notes that with caution should take the medicine for people with asthma and hypertension, instructions for use. "Metoproclamide" can cause health complications in people with liver and kidney pathologies, as well as in the presence of Parkinson's disease.
Children should be under special control when using a medical device, since they have an increased risk of dyskinetic syndrome. The medicine can have a positive result with a vomiting reflex, provoked by the use of cytostatics.
In elderly patients, especially with prolonged use of the drug in high or medium dosage, the appearance of negative reactions in the form of extrapyramidal disorders, including parkinsonism or tardive dyskinesia , is possible .
Warns that the use of the drug "Metoproclamide", instructions for use, can distort laboratory indicators. Pills and injections can cause changes in the rate of aldosterone and prolactin in the blood. This feature must be taken into account by people when taking a blood test.
Experts do not recommend during the treatment with Metoproclamide (the annotation before using the drug should be carefully studied to avoid undesirable consequences) to engage in activities that require increased attention and quick reactions.
Drugs that can replace Metoclopramide
To date, there are not many drugs that can replace the Metoproclamide. Analogs contain the same active substance and have similar properties. These include:
- "Tserukal."
- Perinorm.
- "Metukal."
- "Raglan".
- Apo-Metoclops.
- "Metamol".
- "Cerulan."
- "Melomide hydrochloride."
In all of the above medicines, the main active ingredient is metoclopramide hydrochloride. Thanks to what exactly they and carry to direct analogs of "Metoclopramide". Medicines vary among themselves in cost and manufacturer. Some drugs are produced in Europe using modern equipment that has several degrees of purification.
Should I replace Metoproclamide? Analogs are approximately the same in their performance. They have identical effects on the body and, as a rule, are used in equal doses. Therefore, which remedy is best to choose or leave Metoclopramide should be decided by the patient after consultation with a doctor.
“Tserukal” as an analogue of “Metoclopramide”
Cerucal is the direct and most common substitute for Metoclopramide. The tool removes nausea, hiccups and vomiting of various genesis. It is used in radiation therapy and cytostatics. The medicine has contraindications and can cause a number of negative symptoms. Passes through the blood-brain barrier and breast milk. The highest concentration of the active substance is observed half an hour after the use of the medication.
The cost of medicine ranges from 200-300 rubles. Produce the drug in Germany and Croatia.
Reviews say that it not only relieves bouts of nausea and vomiting, but also effectively removes pain in the stomach with gastritis. Another remedy saves some people from a hangover.
Antiemetic drug "Tserulan"
Another fairly popular analogue of Metoclopramide is Cerulan. Its active substance is metoclopramide hydrochloride. Anti-vomiting agent stimulates intestinal motility, stops vomiting, nausea and hiccups. Normalizes the discharge of bile.
Available in ampoules for injection. It is administered not only intramuscularly and intravenously, but also intranasally. Contraindicated in pregnant and lactating women. The highest concentration of the active component in the blood occurs in half an hour.
It is made in India, by the Rusan Pharma company. The cost of the drug ranges from 200-300 rubles.
You can not use the drug simultaneously with antipsychotics. During the treatment with this tool, you can not drink alcohol, and also drive a car and perform actions that require a quick reaction.
Patient Opinions on Metoclopramide
Talk about the effectiveness and speed of the drug "Metoproclamide" reviews. Patients report only a positive result from its effect. They say that he should be in every medicine cabinet. His ability to stop prolonged vomiting and nausea is noted. Use it for gag reflex associated with oncology, as well as for vomiting and rotavirus infection in children. A medicine is also used for disorders of the gastrointestinal system, as well as for dyskinesia of the bile ducts.
A drug administered intravenously begins to affect the body within 1-3 minutes, which is somewhat faster than the drug in tablets, the effect of which occurs after 15 minutes. The result after taking the medication lasts about two hours.
Pregnant women take this drug for nausea and vomiting in the II and III trimesters. Patients claim that this medicine is often used by doctors to relieve the gag reflex in an ambulance and in a hospital.
After using the product, some people noted dry mouth, tinnitus, drowsiness, lethargy, anxiety, anxiety, and mood swings. They say that it’s good to sleep after taking the medication, then the side effects will pass unnoticed. The drug increases the prolactin in the blood. It is said that the drug does not help with migraines that are accompanied by vomiting.
Despite these shortcomings, patients note the high effectiveness of Metoclopramide. They say that it costs less than “Tserukal”, but, despite this, it is no less effective. So, the cost of this drug in tablets does not reach 50 rubles, and in ampoules it ranges from 60 rubles.