The drug is released in the form of tablets. Pharmacological action based on
antithyroid properties of the active substance - tiamazole (5 mg in 1 tablet). The medicine "Merkazolil", reviews of doctors confirm this, inhibits the action of the enzyme peroxidase, without which the reaction of iodination of thyroid hormones in the thyroid gland is impossible. The result of treatment is a violation of the formation of thyroxine and triiodothyronine.
Thiamazole is well absorbed from the gastrointestinal tract. The half-life is 6 hours. Metabolized in the body, completely excreted through the kidneys.
The drug "Merkazolil", instruction
The drug is prescribed:
- with thyrotoxic crisis ;
- with diffuse toxic goiter;
- with mixed toxic goiter as part of a comprehensive treatment with thyroid hormonal agents or with radioactive iodine preparations.
The medicine "Merkazolil": instructions for use
The doctor chooses the dosage of the drug individually, depending on the condition of the patient. Usually prescribed 20 mg to 40 mg of tiamazole per day. The daily dose is recommended to be divided into 2-4 doses. Normalization of thyroid function is observed after a course of treatment with Merkazolil lasting from 3 to 8 weeks. After the positive results are obtained, the patient is transferred to maintenance therapy with tiamazole in doses from 2.5 mg to 10 mg per day.
The therapeutic daily dose of the drug for children is from 300 mcg per 1 kg to 500 mcg per 1 kg. The maintenance daily dose of the drug for children ranges from 200 mcg per 1 kg to 300 mcg per 1 kg. A maintenance dose of thiamazole is prescribed once, in the morning after breakfast.
Means "Merkazolil": side effects
During clinical trials of the drug, rarely allergic reactions in the form of a rash or fever were observed; in single patients, symptoms of lupus-like syndrome were noted.
Disturbances in the hematopoietic system were rarely manifested by leukopenia, agranulocytosis; in single patients, symptoms of generalized lymphadenopathy were observed.
Disturbances in the digestive system were rarely manifested by a change in taste; in a few patients, liver pathology, vomiting, and nausea were detected.
Violations of the nervous system were found only in isolated cases, manifested by neuritis and polyneuritis, headaches.
Violations of the endocrine system were manifested by hyperplasia of the thyroid gland.
The drug "Merkazolil", instruction: contraindications
Do not prescribe the drug:
- with severe leukopenia or granulocytopenia;
- with increased sensitivity to tiamazole;
- during pregnancy;
- during lactation.
Contraindications to the use of the drug "Mercazolil" by pregnant women are associated with its ability to penetrate the placental barrier. Therefore, the use of thiamazole after the first trimester is fraught with the development of hypothyroidism in the fetus.
Contraindications to the use of the drug "Merkazolil" by breast-feeding mothers are associated with its ability to penetrate into breast milk.
The medicine "Merkazolil", instruction: special instructions
Treatment with thiamazole is associated with the need to regularly monitor the blood picture.
Treatment of large thyroid glands complicated by narrowing of the trachea should be prescribed for a short time. A long course of treatment can provoke struma growth.
It is imperative to consult a patient before starting treatment with Merkazolil to explain the need to see a doctor at the first negative signs of a change in condition. This fever, sore throat, inflammation of the oral mucosa, the appearance of a boil are characteristic symptoms of agranulocytosis.
With the upcoming operation, the appointment of Merkazolil is canceled in 1-2 weeks. Preparation for a stumectomy is carried out with iodine-containing drugs.
It is important to note that a lack of iodine in the patient's body increases the effect of tiamazole, and an excess of iodine reduces the effect of tiamazole.