"Formin": instructions for use, reviews

Currently, more and more people are suffering from diabetes and obesity of a complicated type. There are many drugs to treat these ailments. One of them is the medicine “Formmetin”. About its characteristic features will be discussed in this article.

Pharmaceutical category

"Formin", the instructions for use of which is given in this article, is a hypoglycemic drug of the biguanide group.

Description of the composition and form of release

One tablet contains:

Formetin is available in blister packs of 100, 60 or 30 tablets.
The color of the tablets is white, and the form depends on the dosage of the main substance. At 500 mg they have a cylindrical round shape with a notch and a chamfer. Also, the dosage of 1000 mg and 850 mg is “Formin”. The tablets in this case are convex and oval. They are with one-sided risk.

Pharmacodynamics

Metformin ("Formin") slows down gluconeogenesis that occurs in the liver, and also decreases the glycogen supply in it. This tool helps to complicate the absorption of glucose from the intestine, enhancing the excretion of sugar from the circulatory system. At the same time, the tissue response to insulin increases, without affecting the production of its endocrine part by the pancreas by B cells, bypassing the hypoglycemic reaction, since the production of this substance is not activated.

The drug "Formmetin", reviews of which speak of its effectiveness, reduces the amount of "bad" cholesterol and triglycerides in the blood. The content of high density lipoproteins in this case increases by 20-30%. With an ineffective diet, the drug “Formmetin”, the instructions for use of which are described in this article, helps to reduce and / or stabilize the patient’s weight. This happens due to the oxidation of glucose in an oxygen-free way, as well as a decrease in appetite. Also, the process of plasminogen activation of tissues is dulled by acting on its inhibitor, and there is a hemostatic effect.

Pharmacokinetics

Metformin assimilation begins in the gastrointestinal tract. The maximum content of this substance in the blood is achieved approximately 2.5 hours after use with a degree of absorption of a standard dose of 50-60%. The quality of drug absorption in the body is affected by the relationship between the active substance and the proteins in the plasma. Formetin tablets have no association with plasma proteins. This indicates its effectiveness. Since the lower the binding coefficient, the drug is better absorbed. Deposition occurs in the kidneys, liver, muscle tissue, and salivary glands. In the body, metformin does not undergo changes. It is subsequently excreted by the kidneys. Therefore, if their work is disturbed, cumulation is observed. The biological half-life is 1.5-4.5 hours.

Destination

The medicine “Formin” is used to treat a certain category of diseases. Namely, in the presence of type 2 diabetes, in cases of complicated obesity, when the diet does not help to keep the sugar level normal, even in combination with sulfonylurea. Also effective is "Formin" for weight loss.

How to use?

The doctor chooses the dose of this drug based on the amount of glucose in the blood. Oral administration must be carried out after a meal, while drinking a considerable amount of liquid and without exposing the tablet to mechanical treatment. As already mentioned above, the dosage is prescribed depending on the glucose content in the blood. It starts with a minimum amount of 0.5 g or 0.85 g per day. Two days after the start of treatment with this drug, a constant content of metformin in the blood is observed. If necessary, you can gradually increase the dose to the maximum value. It is equal to 3 grams.

Since the development of lactic acidosis is often observed in older people, the maximum daily dose level is 1 g for them. Also, the amount of the drug is reduced in case of metabolic disturbance, to prevent an allergic reaction, manifested in the form of a skin rash, and other possible side effects that will be discussed below.

Contraindications

In this regard, there are many nuances. The drug "Formin", the instructions for use of which are given in this text, are contraindicated in the presence of:

• Diabetic ketoacidosis, precoma, coma.
• Severe renal impairment.
• Heart and respiratory failure.
• The acute phase of myocardial infarction.
• Dehydration.
• Chronic alcoholism and other conditions that may contribute to the manifestation of the development of lactic acidosis.
• Acute cerebrovascular accident.
• Pregnancy and breastfeeding.
• Hypersensitivity to this affection.
• Serious surgery and injury when insulin therapy is prescribed.
• Severe infectious diseases.
• Impaired liver function.
• Acute alcohol poisoning.
• Lactic acidosis (including a history).
• Hypocaloric diet (less than 1000 kcal. Per day).
• X-ray or radioisotope studies with the introduction of an iodine-containing substance.

Also, it is not recommended to use the drug “Formmetin” for persons over sixty years of age who perform physical hard work. Since in this case they have an increased risk of developing lactic acidosis.

Side effect

The occurrence of such unpleasant symptoms as a “metallic” taste in the mouth, vomiting, nausea, diarrhea, gas, lack of appetite requires stopping the use of therapy and immediately contact a specialist. Long-term use of the drug causes a violation or complete cessation of absorption of vitamin B ₁₂ , which leads to the accumulation of the latter in the body, causing hypovitaminosis. In rare cases, the opposite develops - megaloblastic B ₁₂ deficiency anemia. With the wrong dose, hypoglycemia is possible. Allergic reactions in the form of a skin rash may also occur. Therefore, the drug "Formin", reviews about which on its appropriateness in use, are different, should be prescribed only by your doctor.

special instructions

Important criteria are determined by the peculiarity of the accumulation of the main substance “Formin” in the body and the consequence of this.

To prevent the accumulation of metformin and the prevention of lactic acidosis, it is necessary to monitor the indicators of kidney function and take tests to determine the amount of lactic acid in the body at least 2 times a year. Also, with the appearance of pain in the muscles, a second examination should be done.

The effect of this drug on the ability to control mechanisms and driving vehicles

In this case, there are also certain nuances. The effect of “Formin” on the ability to control mechanisms and transport takes place only if it is used together with drugs that affect work processes, requiring a quick response and an increased concentration of attention. This is important to know.

Use for breastfeeding and pregnancy

The drug "Formin", the instructions for use of which are described in this text, has a category of exposure to the fetus "B" according to the FDA. During pregnancy, this drug can be taken. However, its use can only be in certain cases. Namely, when the expected result from this therapy will exceed the presence of a potential risk to the fetus. Certain and specific studies on the use of such a drug as the drug “Formmetin” were not conducted during the period of pregnancy. At the time of treatment should stop breastfeeding. In any case, you should seek the advice of a qualified doctor.

Drug interaction

Metformin increases blood sugar. This is especially manifested with the simultaneous administration with non-steroidal anti-inflammatory drugs, sulfonylurea and clofibrate derivatives, monoamine oxidase inhibitors, acarbose, insulin, oxytetracycline, cyclophosphamide, adrenergic blocking inhibitors and angiotensin-converting type enzyme.

When used together with endocrine drugs (oral contraceptives, glucocorticosteroids, sympathomimetics, epinephrine, thyroid hormones, glucagon, thiazide and “loop” diuretics, phenothiazine derivatives, nicotinic acid derivatives), inhibition of metformin hypoglycemic process is possible.

With a combination of a drug such as the drug "Formmetin", with "Cimidine", "Nifedipine", the risk of lactic acidosis develops, which inhibits the excretion of metformin from the body. This is observed when taking alcohol-containing products, including as part of drugs.

Cationic agents (quinidine, amiloride, digoxin, procainamide, morphine, quinine, vancomycin, ranitidine, triamteren) formed in the tubules compete for transport systems and, with prolonged treatment, can increase the concentration of the drug up to 60%.

Overdose

An overdose of “Formin” was observed when taking 0.85 grams per day and provoked lactic acidosis. Also, the high content of metformin is due to malfunctioning of the kidneys.

The early symptoms of lactic acidosis are weakness of the whole body, bloating, lowering body temperature, pain in the stomach and muscles, lowering blood pressure, reflex bradyarrhythmia. In some cases, there are manifestations of frequent breathing, impaired consciousness, dizziness and, as a result, coma develops.

At the slightest occurrence of overdose symptoms, it is necessary to stop using the drug and consult a doctor to confirm the diagnosis of lactic acidosis. To remove the active substance of the specified agent and lactic acid from the body, hemodialysis with parallel symptomatic treatment will help.

"Formin": analogues

There are many funds of this type. Analogues of “Formin” are preparations containing in their composition as the main component of metformin hydrochloride. An example is the medicines of Russian manufacturers: Vero-Metformin, Gliformin, Metformin, Metformin Richter, and foreign ones - Glucofag, Glucofage and Glucofage Long (France), Langerin "(Slovakia)," Metfogamma "with different dosages of the active substance 0,100, 0,500 and 0,850 g (Germany).

Terms and conditions of storage

There are certain conditions in this regard. The drug "Formin" is potent, so it is dispensed only by prescription and requires storage at room temperature, out of the reach of children and sunlight. Its shelf life is 2 years.

Cost

The average price of the drug "Formmetin" is set depending on the dosage: from 59 rubles. per blister 0.5 g, 133 rubles. for 0.85 g and 232 rubles. for 1 g.

Conclusion

All of the above contains a lot of useful information. Having become acquainted with this article, everyone will be able to find the answer to the question of how to take “Formmetin” and what properties it has.