Nonsteroidal anti-inflammatory drugs occupy a strong leading position in pharmaceutical markets around the world. These complex effects have an antipyretic, anti-inflammatory and analgesic effect on the human body. One of such medicines is Ibuprom. The instruction regulates it as a very effective remedy for a variety of diseases.
Pharmacodynamics of the drug
Ibuprom is a phenylpropionic acid derivative. The mechanism of influence is based on the suppression of COX activity (an enzyme, a precursor of prostaglandins, which in turn dominate the processes of pathogenesis, the development of pain and fever). Moreover, the drug is characterized by non-selective inhibition of cyclooxygenase, that is, Ibuprom equally inhibits the activity of both isoforms of this enzyme - COX-1 and COX-2.
Instructions for use determine the analgesic effect of the Ibuprom medication by two mechanisms - peripheral and central. Pevy is manifested indirectly through inhibition of the production of prostaglandins. The influence of the second mechanism (central) is to suppress the production of the same prostaglandins in the central and peripheral regions of the NS. Due to a decrease in the lipid of physiologically active substances present in the focus of inflammation, the sensitivity of the perception of chemical stimuli by receptors is reduced. In the hypothalamus in the center of thermoregulation, suppression of prostaglandin synthesis leads to a decrease in body temperature in febrile states.
In addition, Ibuprom tablets (the instructions for the preparation contain such information) to some extent inhibit platelet aggregation (gluing).
The composition and form of release of the drug
Ibuprofen is the main active ingredient of Ibuprom. Crospovidone, silicon dioxide, polyethylene glycol and a number of other substances (gelatin, starch, vegetable oil, sucrose, etc.) can be called auxiliary components.
There are several forms in which the medicine is offered to consumers. The drug can be packaged in a sachet, in a polyvinyl bottle (50 tablets) or in blisters.
Depending on the volume of the main component in the drug, they speak of Ibuprom (200 mg of ibuprofen in one tablet) or the drug Ibuprom Max (400 mg of ibuprofen). However, this is not all. For such a variety as Ibuprom Sprint Caps, the instruction reports that the drug is available in capsules with a dose of 200 mg of the main active substance in each. Ibuprom Extra is also offered to patients in capsules, the volume of the main component in each is 400 mg. About Ibuprom Sinus, the instruction says that one tablet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine hydrochloride.
Indications for use
The description of all the symptoms, when a positive effect is obtained, contains instructions for such an agent as Ibuprom tablets. The composition (analogs of a medication with the same active substance will have approximately the same effect) suggests that the medication will give a positive result in the treatment of diseases such as any inflammatory and degenerative problems in the spine and joints. Arthritis (rheumatoid, rheumatic, psoriatic), osteoarthritis, ankylosing spondylitis is no exception. Assign "Ibuprom" for inflammation of the soft tissues and musculoskeletal system caused by injuries, with radiculitis, bursitis, tendonitis. In addition, the medication is able to cope with headache and toothache, with neuralgia, myalgia, and pain in infectious and inflammatory diseases of ENT organs. Health workers practice the appointment of "Ibuprom" in case of febrile conditions to lower body temperature, with pain of mild or moderate moderation and unclear origin.
"Ibuprom Max" application instruction recommends taking in the presence of the same symptoms, when an increased dose of the drug is required. Ibuprom Extra will also be effective in treating such symptoms.
"Ibuprom Sinus" (synonym - "Ibuprom Sprint Caps") is usually prescribed to provide analgesic, anti-inflammatory and antipyretic effects, as well as to reduce swelling of the mucous membranes of the nose and sinuses. That is, the drug will be effective in the symptomatic treatment of colds, acute respiratory infections and flu, accompanied by headache, sore throat and muscles, high body temperature and inflammation of the mucous membranes of the nose and paranasal sinuses.
Possible applications
"Ibuprom" (tablets) instructions for use recommends that you assign individually for each patient, depending on the intensity of the clinical manifestations of the disease. The standard dosage regimen for this drug is a single dose in a volume of 200 to 800 mg with a frequency of 3-4 times during the day. For young patients, the dosage is selected depending on body weight - 20-40 mg per kilogram of weight (this is the daily volume), divided into several doses throughout the day. The course of therapy usually lasts from 2 to 3 weeks. The maximum allowable dose per day for an adult patient is 2.4 g. Accepted during or after meals and washed down with a small amount of liquid. Dividing the tablet into parts is undesirable.
Ibuprom Max is taken regardless of food, and it is necessary to drink it with a sufficient volume of water. It is undesirable to crush a tablet into parts.
As for Ibuprom Sprint Caps, for patients older than 12 years of age, a single dose is 1-2 capsules with a frequency of every 4-6 hours. Take it during the meal or after. For people of advanced age, there is no need to specially select a dose, with the exception of cases of clearly manifested insufficiency of the functioning of the kidneys and liver.
"Ibuprom Extra" instruction recommends taking 1 capsule every 4 hours (talking about patients older than 12 years), but not more than 3 capsules during the day. The medication is taken after meals, do not chew. For elderly patients, there is no need to specifically select a dose.
"Ibuprom Sinus" is taken before meals 1-2 tablets and washed down with water. Frequency - every 4-6 hours. A maximum of 6 tablets is permissible per day.
Contraindications to taking the medication "Ibuprom"
"Ibuprom" (tablets), the instructions for use prohibit taking for those who have hypersensitivity to ibuprofen or any auxiliary components of the drug. It is unacceptable to prescribe a medication to patients suffering from lesions of the digestive tract of an erosive and ulcerative nature (especially in the acute phase). Ibuprom treatment is also prohibited in the presence of an aspirin triad and in some diseases of the optic nerve. Deviations in the functioning of the hematopoietic system are also grounds for refusing to use any drugs from the NSAID group. The prescription of this drug is not practiced for those patients who have severe impairment of kidney and liver function.
The purpose and use of Ibuprom in parallel with other medicines from the non-steroid group is unacceptable.
As for the Ibuprom Max medicine, the tablets for use prohibit taking the tablets for the same problems as Ibuprom itself.
“Ibuprom Extra”, in addition to all the contraindications described above, is not prescribed if patients have hemorrhagic diathesis, and heart failure. Also, you can not take this drug in violation of the dehydration of the body, provoked by vomiting, diarrhea or the use of an insufficient amount of fluid.
The drug "Ibuprom Sinus" has all the above contraindications. In addition, it is not used for bronchial asthma, diabetes mellitus, with an increased level of thyroid hormones (hyperteriosis). Contraindication is the presence in patients of pheochromocytoma (neoplasms in the tissues of the adrenal glands), prostatic hyperplasia (adenoma).
Negative manifestations
How is Ibuprom tolerated? The instruction contains information about the possibility of developing some side effects from different systems and organs while taking this drug. The largest number of reactions to the use of this NSAID is observed from the gastrointestinal tract. Patients talk about nausea, vomiting, discomfort in the epigastric region, the development of anorexia and ulcerative erosive lesions of the mucous membranes of the digestive tract.
From the side of the central nervous system, headaches, dizziness, agitation, deviations in the processes of sleep and visual perception are often observed. The likely reactions from the hematopoietic system when taking the medication for a long period are anemia, thrombocytopenia, agranulocytosis.
Various allergic manifestations at Ibuprom are possible. Tablets (the instruction contains such information) can provoke the appearance of a rash, the development of Quincke edema. In very rare cases, the appearance of aseptic meningitis is possible (people with autoimmune diseases are most affected), bronchospastic syndrome. As local manifestations, patients claim burning sensations and tingling sensations on the skin, and hyperemia.
“Ibuprom Sinus”, in addition to all of the above, can cause the development of shortness of breath, tachycardia, increased blood pressure, hyperhidrosis.
Exceeding the permissible dose: consequences
In case of an overdose of drugs such as Ibuprom and Ibuprom Max, the instructions for use report the possible development of nausea and vomiting, pain in the epigastrium. Also in this situation, drowsiness may occur, headache and dizziness may be felt, possibly lowering blood pressure and the development of arrhythmia. In severe situations, symptoms of metabolic acidosis are manifested, loss of consciousness with a violation of respiratory function may occur.
In such conditions, urgent gastric lavage and symptomatic treatment are recommended. Oral administration of enterosorbents is practiced. Convulsive syndrome is relieved with the help of "Diazepam", "Lorazepam."
In case of an overdose of Ibuprom Sprint Caps, in addition to all of the above, there is a possibility of disorientation, convulsions, and coma. Possible liver dysfunction. In patients suffering from bronchial asthma, the course of the disease may worsen.
Long-term use of the ibuprom sinus medication can cause pathological changes in the blood, such as hemolytic anemia (increased breakdown of red blood cells), granulocytopenia (decreased granulocytes), thrombocytopenia (decreased platelet count).
What should I look for?
"Ibuprom" instructions recommend taking with caution for those who have concomitant diseases of the liver, kidneys, chronic heart failure. If the patient has dyspeptic symptoms before starting therapy, or the patient has just undergone surgical intervention, Ibuprom treatment should also be started with great care. The presence of a history of information about bleeding of any nature, about diseases of the digestive tract, allergic manifestations associated with treatment with non-steroidal anti-inflammatory drugs, should also be a reason for attentive attitude to the patient's condition.
To avoid unpleasant surprises, it is necessary to constantly monitor the functions of the kidneys and liver, and the picture of peripheral blood during the use of Ibuprom.
Both Ibuprom and Ibuprom Max do not recommend the use in the 3rd trimester of pregnancy. In the 1st and 2nd trimesters, the use of this NSAID is justified only when the expected positive effect for the mother exceeds the possible negative consequences for the child.
Ibuprofen, the main active ingredient of Ibuprom, is excreted in small doses with breast milk, therefore it can be used during lactation to relieve pain and fever. However, if the question arises about long-term therapy with the help of Ibuprom or about the need to take large doses, you should discuss with your doctor the issue of refusal from breastfeeding.
The use of "Ibuprom Sinus" during gestation and breastfeeding is generally contraindicated.
Interaction with other drugs
Any form of Ibuprom (Ibuprom Max, Ibuprom Sprint Caps, Ibuprom Extra) is forbidden to take the instructions for use along with antihypertensive drugs and diuretics such as furosemide, hydrochlorothiazide, since their therapeutic effect can be significantly reduced.
The use of Ibuprom in tandem with antiplatelet and selective serotonin inhibitors increases the risk of developing LCD bleeding. Further, this NSAID is able to increase the content of glycosides in blood plasma and, thus, cause an exacerbation of heart failure. Ibuprom will enhance the effect of anticoagulants on the human body. For this reason, it is important to regularly monitor blood coagulation indicators, since ibuprofen significantly reduces platelet aggregation.
In parallel use with lithium preparations and Methotrexate, the level of these substances in the blood plasma will significantly increase. A tandem with cyclosporine will increase the nephrotoxicity of the latter.
The combination of "Ibuprom" with digitalis preparations (digitalis) can cause the development of cardiac arrhythmia. You can also not take this NSAID in tandem with acetylsalicylic acid (aspirin), since there is a possibility of an increase in negative side effects.
The combination of quinolone antibacterial agents and any NSAIDs (including Ibuprom, among others) increases the risk of convulsive syndrome. A combination with a medication such as Zinovudine increases the risk of developing hemarthrosis and hematomas in HIV-infected patients.
Patient opinions about the drug
Nonsteroidal PVA are serious drugs with, as a rule, a wide spectrum of effects. Therefore, patient reviews about such funds are always both positive and negative. Ibuprom is no exception.
The bulk of people taking the drug, was pleased with its effect. Pain sensations quickly stop and for a long time do not resemble themselves. The drug has worked well for painful menstruation, headaches and myositis, with myalgia and neuralgia.
At the same time, there are patients who were dissatisfied with the influence of the Ibuprom medication. The instruction states the rapid development of the effect of analgesia, but many consumers have not felt the effects of this drug at all. In addition, many complained of adverse reactions in the form of nausea and headaches.
A sufficiently large group of people complained that Ibuprom did not completely relieve toothache. Although in this case it is not worth saying that the drug is bad. The fact is that, for example, with acute pulpitis, no pain medication will help, except by injecting directly into the gum. In the case of toothache, Ibuprom is an opportunity to get to the dentist as quickly as possible without experiencing severe pain.
In any case, NSAIDs are a new generation of analgesic and anti-inflammatory drugs that are effective in a very wide range of pathologies. This is the opinion of most consumers and healthcare providers.