Infectious diseases, if left untreated, can pose a great threat to human life. Amoxicillin is a broad-spectrum antibacterial that is used to eliminate various bacterial infections. How to take "Amoxicillin" - with food or after?
Release form
"Amoxicillin" is made in the form of oval or oblong biconvex tablets from milky to yellow in color with risks on both sides.
Capsules have in their composition the main trace element - amoxicillin trihydrate.
Additional components are the following substances:
- sodium carboxymethyl starch;
- polyvidone;
- a salt of magnesium and stearic acid;
- talc;
- tetravalent titanium amphoteric oxide;
- hypromellose.
The properties
"Amoxicillin" refers to semisynthetic drugs from the penicillin group. The spectrum of action of this drug lies in its ability to inhibit strains of bacterial cell membranes, which leads to cell death and dissolution.
Amoxicillin is especially active against the following bacteria:
- staphylococci;
- streptococci;
- enterococci;
- Escherichia;
- Borrelia
- Salmonella
- Shigella
- hemophilic bacillus;
- chlamydia;
- clostridium.
The active substance is not destroyed under the influence of gastric juice and is completely absorbed from the digestive system. The maximum blood content reaches after two hours. With an increase in dosage, its concentration also doubles. The absorption process does not depend on the presence of food in the stomach.
The addition of the main trace element to blood proteins is 20%. "Amoxicillin" is distributed throughout all cells and body fluids. It instantly enters the lung tissue, as well as the middle ear fluid, urine and bile. With a high content, it accumulates in the liver.
The half-life is one and a half hours. In people of retirement age and babies, the half-life of the active trace element takes much longer. With kidney disease, this process lasts up to 20 hours. About 60% of the active substance is excreted in urine, a small part - in the intestine, together with feces.
In case of damage to the soft cerebral cavity, a small amount of the drug can easily penetrate a certain barrier and self-destruct during hemodialysis. The drug enters the placenta and is excreted in milk.
Indications
Amoxicillin tablets must be taken in the presence of the following disorders and diseases:
- Bacterial diarrhea (diarrhea).
- Dysentery is an infectious lesion that is characterized by general intoxication and inflammation in the stomach and intestines.
- Middle and external otitis media.
- Acute and subacute endocarditis is a disease that affects the inner lining of the heart, as well as aortic and cardiac valves.
- Sinusitis is an inflammation of the sinus mucosa.
- Acute pharyngitis is an inflammatory disease localized in the pharynx that affects its mucous layer.
- Chronic bronchitis is an inflammatory lesion of the bronchi that affects the mucous cavity or the entire wall of the bronchi.
- Inflammation in the bladder.
How to administer Amoxicillin before or after a meal?
Reception methods
The dosage regimen of Amoxicillin is individual for each patient. A single dosage for adults and children over ten years of age and weighing more than 40 kilograms is from 250 to 500 milligrams. With complex forms of the disease - up to one gram, according to the instructions. Do you take Amoxicillin before or after a meal?
For babies up to two years, a single daily dosage is 20 milligrams per kilogram of weight.
Children from five to ten years old must take 125 milligrams.
The time interval between doses of the medication should be approximately eight hours. In patients with impaired renal function, the interval increases from 12 to 24 hours.
How to take "Amoxicillin Sandoz" - before or after a meal, is described in the following sections.
Adult patients are prescribed 500 milligrams three times a day. With a complex course of the disease, it is recommended to take one gram three times a day.
Children aged five to ten are prescribed 250 milligrams three times a day. Small patients (two to five years old) are recommended to receive 125 milligrams per day. For babies up to two years, the medicine is prescribed at the rate of 20 milligrams per kilogram of weight.
The duration of treatment varies from 5 to 12 days. To eliminate acute gonorrhea, three grams of Amoxicillin are prescribed once. Representatives of the beautiful half of humanity need to repeat the treatment every other day. How to take "Amoxicillin" - before or after a meal, the attending physician should tell.
However, according to the instructions, in order not to expose the mucous cavity to the irritating effect of an antibacterial agent, it is necessary to take the drug during or after a meal.
Side effects
"Amoxicillin" has certain negative manifestations if used improperly, for example:
- nettle fever;
- erythema;
- damage to the mucous membrane of the visual organ;
- anaphylactic shock;
- Lyell's syndrome - the most severe variant of allergic bullous dermatitis;
- depression;
- cardiopalmus;
- acute or chronic inflammation of the venous wall;
- neutropenia;
- hemolytic anemia;
- pancytopenia.
In addition to these symptoms, others may occur, for example:
- inflammation of the tissues of the tongue;
- damage to the mucous membrane of the oral cavity;
- inflammatory liver diseases;
- pain in the stomach;
- pseudomembranous colitis;
- violation of the frequency and depth of breathing;
- interstitial nephritis;
- migraine;
- thrush.
Interaction with other drugs
When taking "Amoxicillin" with aminoglycosides, laxatives and antacids, a decreased absorption was recorded, and when used together with vitamin C, metabolism is enhanced.
Medicines that block the transport of substances from the blood into the lumen of the tubules become a source of increasing the concentration of Amoxicillin, and when used together with Methotrexate, the toxicity of the latter increases.
When using the medication with Metronidazole, nausea, vomiting, diarrhea, and pain in the stomach are intensified.
When used in conjunction with clavulanic acid, the following ailments may appear - cholestatic jaundice and hepatitis.
It is not recommended to combine with "Disulfiram". It is important to be careful when taking the drug with anticoagulants.
When using Amoxicillin with Probenecid, the serum content of the antibacterial agent increases and its excretion from the body worsens. Amoxicillin reduces the effectiveness of oral contraceptives.
Contraindications
The drug "Amoxicillin" has a number of prohibitions on use, such as:
- Hypersensitivity to trace elements of the drug.
- Severe damage to the digestive tract.
- Acute lymphoblastic leukemia.
- Acute anthroponotic infection caused by the Epstein-Barr virus.
- Bronchial asthma.
- The hereditary predisposition of the human body to the occurrence of certain pathological reactions or diseases.
Features
The drug should be taken with extreme caution if there is a tendency to allergies. Patients under the age of 18 and people who suffer from liver diseases should not use the medicine at the same time as Metronidazole.
In case of kidney failure, the dosage of Amoxicillin should be reduced, and the interval between procedures should be increased. When conducting therapy, it is important to periodically monitor the functioning of the liver, kidneys and blood formation organs.
So, how to take "Amoxicillin" - before or after a meal? To minimize the risk of complications from the digestive system, it is necessary to take the drug after eating or during it. There is no information about the negative effect of the drug on the ability to drive a car.
How to store the drug?
It is recommended to store Amoxicillin in a dark and inaccessible place for children at a temperature of no higher than 25 degrees. The drug is dispensed from pharmacy points strictly according to the prescription. Shelf life is 36 months.
Amoxicillin: analogues
The medicine has substitute drugs both in spectrum of action and in composition, these drugs include:
- Amosin.
- Amoxisar.
- Flemoxin.
- "Ecobol".
- Ospamox.
- "Ranoxyl."
The cost of Amoxicillin varies from 40 to 60 rubles. As for the analogues of the drug, they can be more expensive.