“Caposide" is a combined antihypertensive drug. The drug is made in tablet form. Milk-colored tablets, oval with a notch. A medication is produced in contour cells of 14 pieces. Photo "Caposide" and instructions for use are given in the article.
Structure
The structure of one tablet includes the following active trace elements:
- captopril;
- hydrochlorothiazide.
Additional substances are the following components:
- stearic acid;
- cellulose;
- magnesium stearate;
- starch;
- lactose.
Pharmacological properties
According to the instructions for use with Caposide, tablets are a complex medicine that has a diuretic and antihypertensive effect. Captopril (the active substance) is considered to be a delaying agent of the angiotensin-converting strain, it slows down the transition of the first kind of angiotensin to the second kind of angiotensin, reduces the process of aldosterone excretion, reduces peripheral vascular resistance, and normalizes blood pressure.
Captopril helps to expand the arteries, stimulates the renal blood flow. With prolonged therapy, a decrease in hypertrophy of arteries and myocardium is observed. And also the active substance prevents the integration of platelets and increases blood supply to the heart muscles.
Hydrochlorothiazide is a thiazide diuretic that exhibits moderate therapeutic activity. The substance reduces the degree of absorption of sodium ions, which is carried out in the cortical segment of the Henle loop, reduces blood pressure as a result of changes in the activity of blood vessels, weakens the effects of vasoconstrictor components of endogenous origin.
Hydrochlorothiazide enhances the hypotensive effect of captopril. The diuretic effect after taking the pill inside is observed after about two hours. The substance reaches its maximum concentration after four hours. The duration of pharmacological effects varies from 6 to 12 hours.
The safety of captopril when prescribed to small patients has not been proven to date. In the literature there are cases of limited use of the drug in pediatrics. In babies, the likelihood of hemodynamic adverse reactions increases. In rare situations, with therapy with this drug, patients had a prolonged increase in blood pressure, which is sometimes accompanied by complications, including a decrease in daily urine output.
Indications
When is such a drug prescribed? According to the instructions for use, "Caposide" at what pressure can be taken? recommended for use with persistent pressure increase of more than 140 to 90 units.
Contraindications
The drug has a number of limitations in use, for example:
- Angioneurotic edema.
- Aortic stenosis.
- An autosomal dominant disease characterized by thickening of the left ventricular wall.
- Liver disease.
- Clinical syndrome that develops as a result of excessive aldosterone production by the glomerular zone of the adrenal cortex.
- Lactose intolerance.
- Pregnancy.
- Age to eighteen.
- Hypersensitivity to the components of the drug.
The medication is recommended to be used with extreme caution (according to the instructions for use with “Caposide”) for certain diseases. The drug can take instructions for such ailments:
- Hypokalemia.
- Proteinuria
- Hypovolemia.
- Hyponatremia.
- Hyperuricemia
- Scleroderma.
- Systemic lupus erythematosus (systemic autoimmune disease affecting the vessels and connective tissue).
- Periarteritis nodosa.
- Myopia.
- Old age (over sixty five years old).
Instructions for use
The drug "Caposide" must be taken orally one hour before a meal. Daily dosing - one tablet.
Adverse reactions
A drug can provoke a number of undesirable reactions if used improperly, for example:
- Tachyarrhythmia is an abnormally fast heart rate.
- Tachycardia is an increase in heart rate (from 90 beats per minute).
- Angina pectoris is a clinical syndrome characterized by a sensation or discomfort behind the sternum.
- Postural hypotension is a syndrome of an instant drop in blood pressure to critical levels.
- Myocardial infarction is one of the clinical forms of coronary heart disease occurring with the development of ischemic necrosis of the myocardial site.
- Raynaud's syndrome is a vasospastic disease characterized by a paroxysmal disorder of arterial circulation in the vessels of the limbs.
- Vomiting
- Diarrhea.
- Constipation.
- Anorexia.
- Aphthous stomatitis.
- Stomach ulcer.
- Glossitis is a pathological inflammation of the tissues of the tongue, which is often a symptom of general diseases of the body.
- Pancreatitis is an inflammatory disease of the pancreas.
- Hyperbilirubinemia.
- Dizziness.
In addition to these side effects, in rare cases, the following may also occur:
- ataxia;
- paresthesia;
- syncope;
- stroke;
- eosinophilic pneumonitis;
- bronchospasm;
- rhinitis;
- polyuria;
- oliguria;
- arthralgia;
- myalgia;
- gynecomastia;
- impotence;
- erythroderma;
- hives;
- photosensitivity;
- agranulocytosis;
- neutropenia;
- pancytopenia;
- lymphadenopathy;
- anemia;
- alopecia.
Overdose
The following conditions can be attributed to signs of poisoning:
- kidney disease
- a sharp decrease in blood pressure;
- bradycardia;
- lethargic condition.
In rare cases, delayed activity of the gastrointestinal tract and irritation of its mucous cavities can be observed. If symptoms of an overdose occur, you must immediately take certain measures that will help bring the patient out of a state of stupor. Then it is necessary for a sick person to rinse the stomach, inject adsorbents.
Hemodialysis is effective in this situation, and with severe bradycardia, the use of atropine. The active substance (catopril) is not excreted from the body using peritoneal dialysis due to its inefficiency.
Interaction with other drugs
In order to avoid the occurrence of negative side effects and changes in pharmacological effects, before combined use with other medicines, it is necessary to consult a specialist, according to the instructions for use.
Analogs of "Caposide"
Substitute drugs are:
- "Co-Diroton";
- Normopres
- Lysiniton;
- "Metoprolol";
- “Kaptopres-Darnitsa”;
- Cordaflex
- "Atenolol";
- Ventavis;
- Corvitol;
- "Biprol";
- "Ionik";
- "Capotiazide."
“Caposide” is dispensed from drugstores strictly according to the prescription. Store the drug in a place inaccessible to children at temperatures up to 25 degrees. Shelf life is 36 months.
"Metoprolol"
The drug is a representative of the therapeutic group beta-blockers. "Metoprolol" is used to lower blood pressure and reduce the load on the cardiovascular system.
The tablets have a rounded shape, but depending on the dosage, they may have a pink or light yellow hue. The active component of the drug is metoprolol tartrate. Its concentration in one capsule is 50 and 100 milligrams.
Metoprolol is sold in blisters of 10 and 14 pieces. The package contains two, three and four blisters with the corresponding number of tablets.
After using the drug, an orally active microelement is instantly and absolutely completely absorbed into the blood from the intestinal lumen. It is evenly distributed throughout the tissues of the whole body, exchanged in the liver with the appearance of inactive decay products, which are excreted in urine. The cost of the drug is from 40 to 400 rubles.
Corvitol
A drug with antianginal and hypotensive effect. The drug is released in tablet form. Tablets are packaged in blisters of ten pieces, and in total there may be three, five and ten blisters in the package.
The medication must be taken orally after a meal. Tablets should be swallowed whole without chewing and drinking with water. If necessary, they can be divided in half. Corvitol should be used twice a day - in the morning and evening hours.
It is not worth adjusting the dosage regimen for patients of retirement age with functional kidney damage, and also if hemodialysis is necessary.
In case of functional malfunctions in the liver, the dosage of Corvitol must be reduced depending on the condition of the patient. The duration of therapy is not limited. The duration of treatment is determined by the characteristics of the disease and the condition of the patient.
Drug withdrawal must be carried out gradually, reducing daily dosing for ten days. With a sharp cessation of therapy, the withdrawal syndrome is allowed, which manifests itself in the form of an increase in angina attacks and an increase in blood pressure.
With angina pectoris, the dosage of the drug is selected so that treatment at rest improves the heart rate. Corvitol may “hide” certain signs of thyrotoxicosis.
Biprol
A medication from the group of adrenergic blockers, which is used to eliminate arterial hypertension, as well as coronary heart disease and heart failure. The main trace element of Biprol is bisoprolol.
If the use of the active substance is accompanied by not very good tolerance or a pronounced decrease in blood pressure, then the dosage is increased gradually - once every 30 days.
The use of the drug is not recommended to be interrupted abruptly, since serious negative reactions are likely to develop. If you skip at least one dose, you do not need to increase the dosage at the next dose.
Use "Biprol" is necessary in the morning: once every 24 hours before eating, washed down with water.
You can use the drug during pregnancy, but only when weighing the benefits and risks to the health of both the mother and the baby. But two to three days before birth, the use of the drug is stopped, since the likelihood of serious adverse reactions in the child increases.
With lactation, you can use "Biprol". In this case, it is necessary to carefully monitor the general condition of the child.
With a weak or moderate degree of damage to the renal and hepatic functions, dosage adjustment is not necessary. In a severe stage, therapy should be carried out carefully and with extreme caution.
The cost of Biprol is about 250 rubles.
Opinions
According to the instructions for use and reviews of "Caposide", the drug is considered highly effective. Among its advantages, people indicate instant exposure, as well as the possibility of application over a long period.
Some reviews are negative, and in them patients complain of side effects. The cost of "Caposide" is approximately 600 rubles.