"Doxycycline" refers to antimicrobials for systemic use. Like Doxycycline itself, analogues of this drug are part of the tetracycline group. They have a spectrum of fairly broad action aimed at combating microbes.
The most famous analogues of the Doxycycline drug are Unidox Solutab, Doxycycline Hydrochloride, Doxybene, Doxycycline Darnitsa and some others. Quite often, one can observe how a person doubts what he should get, Doxycycline or Unidox, for example. It should be noted that the pharmacodynamics of these drugs are the same. Thus, they are all active against gram-positive (Stamphylococcus spp., Streptococcus spp., Actinomyces Israeli, Clostridium spp., Listeria monocytogens, Bacillus anthracis) and gram-negative (Neisseria gonorrhoeae, Vibrio cholerae, Bordetpperppert peruss. Klebsiella spp., Escherichia coli, Salmonella spp., Shigella spp.) Microargonisms. Sensitive to Doxycycline and its analogues Mycoplasma spp., Rickettsia spp., Treponema spp., Borrelia burgdorferi, Chlamydia spp., Some protozoa (including Entamoeba histolytica, Plasmodium falciparum). The most sensitive to analogues of "Doxycycline" Haemophilus influenza (91-96%) and intracellular pathogens.
The only significant detail that distinguishes analogs from the Doxycycline preparation is that it is less than other tetracycline drugs that worsen the intestinal flora, and also has a longer duration of action and more complete absorption. Antibiotics from a number of tetracyclines penetrate into the cell and inhibit the reproduction of pathogens located there. According to the degree of bacterial activity, the drug "Doxycycline hydrochloride" is superior to all other tetracyclines, including natural ones.
Like the drug "Doxycycline", its analogues have the following indications for use:
- infections of ENT organs;
- respiratory tract infection;
- infection of the genitourinary system;
- infection of soft tissues and skin;
- infection of the biliary tract and gastrointestinal tract;
- osteomyelitis, brucellosis, whooping cough;
- syphilis, yersiniosis, malaria, frambesia, Q fever, legionellosis, typhoid, rickettsiosis, Lyme disease, chlamydia of various localization, bacillary and amoebic dysentery, cholera, tularemia, actinomycosis;
- as part of general therapy - granulocytic ehrlichiosis, leptospirosis, psittacosis, trachoma, ornithosis;
- subacute septic endocarditis, sepsis, peritonitis.
It is forbidden to use Doxycycline with strong sensitivity to tetracyclines, severe liver failure, porphyria, during pregnancy, lactation (breastfeeding should be avoided during the period of taking the drug), children under 12 years of age. With caution, it is worth taking this medication to people who have impaired liver function, leukopenia.
The drug "Doxycycline" may have side effects on:
- nervous system (toxic effect on the central nervous system, intracranial pressure above normal);
- hearing organs (a noise appears in the ears);
- digestive system (enterocolitis, vomiting and nausea, diarrhea or constipation, gastritis, dysphagia, glossitis, esophagitis, manifestation of the stomach and duodenum);
- from the cardiovascular system (edema, tachycardia);
- hemopoietic organs (thrombocytopenia, eosinophilia, hemolytic anemia, neutropenia, porphyria);
- reactions indicating allergies (skin hyperemia, pruritus, anaphylactoid reactions, maculopapular rash, Stevens-Johnson syndrome, antigioneurotic edema);
- other (hepatitis, jaundice, myalgia, arthralgia, photosensitivity, a strong change in the color of tooth enamel, inflammation in the anogenital zone, candidiasis, dysbiosis).
In case of an overdose of Doxycycline, the following symptoms can be noted: hepatotoxicity, more pronounced side effects. In this case, you should immediately seek medical help, discontinue the drug and conduct symptomatic therapy (since there is no specific antidote), it is also necessary to maintain and control how vital functions proceed.