In modern pharmacies, you can find a huge amount of medications designed to eliminate inflammatory processes and pain. One of the most effective among these drugs is deservedly considered candles "Indomethacin". This non-steroidal anti-inflammatory drug helps minimize swelling, inflammation and soreness.
General information
This medicine is made not only in the form of suppositories, but also in the form of a gel, capsules and ordinary tablets. Rectal suppositories are very effective in combating a variety of pathologies, including hemorrhoids and prostatitis. True, the drug helps in the treatment of not only male diseases.
For example, according to the instructions, Indomethacin suppositories can also be used in the treatment of gynecological defects in women. The drug is uniquely highly effective, and the numerous positive reviews of patients who used this tool are considered to be the main confirmation.
But at the same time, it is worth remembering that Indomethacin is a powerful medication, therefore its inappropriate use can cause extremely unpleasant consequences for the body. That is why, before proceeding with its use, you should definitely get a specialist consultation and learn about all kinds of contraindications and features of the drug.
Today, Indomethacin suppositories are in great demand in many areas of medicine.
Release form
The substance indomethacin is a derivative of indoleacetic acid. It has a pronounced anesthetic and anti-inflammatory effect. This drug is a non-steroidal medicine. Due to its effectiveness and accessibility, the tool has found wide application in the treatment of inflammatory processes of various etiologies.
Despite the variety of forms of release, it is Indomethacin suppositories that have the most powerful effect on the body, helping to prevent fever, eliminate swelling and remove inflammation.
As a rule, suppositories are used rectally - most often they are injected into the rectum. However, in some situations, gynecologists recommend that women use the drug vaginally.
Suppositories in contour packs of 6 and 10 pieces are available. The product contains 50 or 100 mg of the active ingredient. Candles have a cylindrical shape, a hard shell and a white or cream shade.
The composition of the drug
The main active ingredient of the drug is indomethacin. In addition, the composition of the medication includes auxiliary components.
- Semi-synthetic glyceride is an additional active ingredient. Its content reaches 2 grams. This ingredient along with indomethacin helps eliminate inflammation and relieve swelling.
- Solid fat, thanks to which suppositories have a stable form. When ingested, this component dissolves, and most importantly, the active substance easily spreads and penetrates the walls. Fat also helps soften tissues, making the surface of the intestine more sensitive to the drug. It is due to the presence of suppositories in the composition of this ingredient that a yellowish or whitish color is obtained.
- Corn starch. This component helps protect the mucous membrane from a powerful irritating effect, and also participates in the neutralization of acids and the enveloping of receptors by the resulting mucus. As a result, after complete dissolution, starch is converted to glucose and carbohydrates. In addition, this ingredient also helps nourish nearby tissues and nourish the body with energy.
Today, the drug is manufactured in several countries at once:
- in Germany by Berlin-Chemie;
- in Russia by Biosynthesis and Altpharm firms;
- in Bulgaria - Sofarma.
Pharmacological properties
After the suppository is introduced into the rectum under the influence of human heat, it begins to actively melt. As it dissolves, the active ingredient penetrates the intestinal wall, providing a therapeutic effect.
The tool has several effects in parallel:
- antipyretic;
- painkillers;
- anti-inflammatory;
- decongestant.
Penetrating directly into the bloodstream, completely avoiding the stomach and intestines, it is absorbed by the body and inhibits the production of the hormone prostaglandin. It is this element that controls the rapid progression of the pain syndrome and the inflammatory process.
With the systematic use of suppositories "Indomethacin" can eliminate all inflammations that are chronic in nature, while eliminating pain and a feeling of stiffness. After only a week of regular use of the drug, significant improvements can be noticed.
After penetration into the plasma, the main active substance of the drug is concentrated to a maximum after about 1-2 hours. It is noteworthy that during this period it is advisable to refrain from eating, as the result of the drug will be reduced, regardless of the amount of food consumed.
Indomethacin has an extremely high absorption rate. At the end of its action, the substance is excreted from the body through the digestive tract and kidneys. But women should know that against such a quick effect, derivatives of the drug are able to penetrate the placenta and breast milk.
Features
In addition, the use of Indomethacin suppositories helps:
- blood thinning;
- prevention of blood clots;
- minimize inflammation;
- separation of glued platelets and reduction of their aggregation;
- elimination of fever and stabilization of body temperature;
- blocking nerve receptors;
- eliminate pain 15 minutes after the introduction of the suppository.
Unlike tablets, suppositories have a significant advantage: they are not affected by enzymes and acids of the digestive system, but penetrate immediately into the blood circulation.
Indications for use
Suppositories are often prescribed not only by therapists, but also gynecologists, and even proctologists to help the patient get rid of various inflammatory processes of a local and general nature.
Indomethacin suppository indications are:
- gout;
- thrombophlebitis;
- myalgia;
- inflammation of the bone tissue of the musculoskeletal system;
- rheumatism;
- radiculitis;
- sciatica;
- inflammation of the ENT organs;
- osteoporosis;
- hemorrhoids;
- prostatitis in men;
- osteochondrosis;
- arthritis;
- neuralgia;
- Ankylosing spondylitis syndrome;
- disorders of protein metabolism.
As you can see, suppositories can help patients with a wide variety of problems.
Other applications
Vaginal suppositories "Indomethacin" are used to treat gynecological pathologies in women. This method of application is often recommended to alleviate the clinical manifestations of hemorrhoids.
Often, indomethacin suppositories are used as an effective painkiller for menstruation or serious inflammation, which are accompanied by endometriosis and cystitis. But it is worth noting that patients with such diagnoses cannot do only with this drug - it will be truly effective only as part of complex therapy.
In gynecology, Indomethacin suppositories are often prescribed even to pregnant women because of their relative safety and high effectiveness, to eliminate uterine hypertonicity. True, in this case, suppositories can be used both vaginally and rectally.
Most often, complex therapy is used to treat complex defects, one of the components of which is this drug, and the other is antibiotics.
With this treatment regimen, you can get rid of the symptoms:
- ovarian cysts;
- inflammation in the appendages;
- uterine fibroids.
Sometimes the remedy helps women with the threat of miscarriage.
In gynecology suppositories "Indomethacin" are used quite widely, allowing you to cope with the problems of various pathogenesis. However, as a rule, doctors recommend this drug in conjunction with other medicines, most often of the antibacterial type.
No less effective are Indomethacin suppositories for prostatitis in men, in particular its chronic form and seasonal exacerbations. Rectal suppositories positively affect the parameters of the prostate and bring a stable anti-inflammatory effect.
Suppositories "Indomethacin" during pregnancy
In the first trimester of gestation, the use of suppositories is not recommended, because in this period the internal organs of the embryo are formed. And the use of indomethacin suppositories can provoke pathologies of the development of the baby.
The second trimester is an exception, and if there is evidence, a short course of treatment with the help of suppositories is allowed.
In late pregnancy, Indomethacin suppositories are generally not prescribed.
During lactation, the use of suppositories is allowed only in case of interruption of breastfeeding.
Instructions for candles "Indomethacin"
Use the drug only for children over 14 years of age, and adults only on the recommendation of a doctor. Only a specialist is able to correctly select the appropriate dosage of the drug, the duration of treatment and the method of application.
But usually the drug is used one candle 1 or 2 times during the day for no longer than two weeks. Women are advised to use suppositories vaginally at bedtime. Men diagnosed with prostatitis are usually prescribed one suppository in the evening and morning.
Side effects
Due to the selection of the wrong dosage, the patient's body may react negatively to the incoming medicine. As side effects from suppositories, "Indomethacin" is most often manifested:
- migraine;
- Dizziness
- diarrhea and other indigestion;
- slight yellowing of the skin;
- excessive susceptibility to bright lighting;
- chronic weakness.
Sometimes a medication affects the body more and provokes other disorders:
- pain in the throat;
- nosebleeds;
- allergic reaction - rash, swelling, asthma;
- ringing in the ears or even complete lack of hearing;
- stress, depression, causeless anxiety, insomnia;
- lack of appetite;
- constipation or diarrhea;
- bloating;
- pain in the heart;
- arrhythmia.
Analogs
Substitutes for this drug include medications that have identical therapeutic properties. But at the same time they can have a different chemical composition.
The most popular analogs of Indomethacin suppositories are:
These drugs are very similar in their chemical structure, and indomethacin is also their active ingredient.
If the patient has an individual intolerance to this substance, medicines may be prescribed with identical properties, but with a different composition:
- Ibuprofen
- Diclofenac
- Butadion.