The medicine "Pradax" belongs to the category of anticoagulants, direct (immediate) thrombin inhibitors. The active substance is dabigatran etexilate. After penetration into the body, rapid absorption is noted. Isolation of the drug is carried out by the kidneys (mainly). A small amount leaves through the intestines. Means "Pradax" - a drug that helps to lengthen the partial activated thromboplastin time.
Appointment
The medication "Pradax" instruction recommends for the prevention of venous thromboembolism in patients who underwent extensive orthopedic surgery.
Dosage regimen
The drug is drunk on an empty stomach or with food. To prevent venous thromboembolism, the recommended dose of 220 mg once a day (two capsules of 110 mg). If the patient has a mild renal impairment, the risk of bleeding increases. In this regard, the Pradaxa remedy (instructions for use contains such data) is prescribed to such patients 150 mg per day (2 capsules 75 mg each). After hip arthroplasty is performed, therapy should be started 1-4 hours after the end of the intervention. The initial dose is a 110 mg capsule. Subsequently, a gradual increase in the amount of medication to 2 caps. 2 r / day Duration of admission is ten days. With unstable hemostasis, therapy with Pradaxa (the instruction recommends this) should be postponed. In case of delaying the start of treatment, the dosage is 2 caps. once a day.
Adverse reactions
The medication "Pradax" (the instruction warns about this) can cause disorders of the liver, changes in its functioning indicators of a transient type. The negative consequences include bleeding, hemorrhages, hematomas. The tool can provoke thrombocytopenia, epitaxis, anemia.
Contraindications
The Pradax medication is not recommended for hemorrhagic syndrome, severe renal failure, intolerance to one of the components. Contraindications include organic lesions due to clinically significant bleeding, including after a hemorrhagic stroke in the period of the last six months before the start of therapy. The medication is not prescribed for patients with a catheter in the spinal canal or epidural space, as well as during the first sixty minutes after its elimination. Contraindications to the use of Pradaxa (instructions indicate this) include lactation, pregnancy. Medication under the age of eighteen is not recommended.
additional information
When the capsules are released, they should not be squeezed out of the foil. The medicine is removed from the blister, peeling the package in the direction indicated by the arrows. It is recommended to remove the foil so that it is convenient to get the capsules. With the simultaneous use of Pradaxa (instructions indicate this) with medicines that affect coagulation or hemostasis, including vitamin K antagonists, a significant increase in the risk of bleeding is likely.