The article describes the characteristics of the drug "Lidase", instructions and patient reviews.
The tool is an enzyme preparation that is isolated from the seed appendages of cattle. Promotes the breakdown of hyaluronic acid, a decrease in its viscosity. It is able to increase the permeability of tissues and blood vessels, facilitate the penetration of liquids into interstitial spaces, reduce swelling, soften scars, reduce contracture, and increase articular range of motion.
Structure
According to the instructions for "Lidase", the basis for the production of the drug are cattle seed. The main active ingredient in its composition is hyaluronidase. In addition to it, some auxiliary components are also used.
Pharmacological forms
To date, the manufacturer produces the drug in several pharmacological forms:
- Powder intended for outdoor use.
- Lyophilisate, from which a solution is prepared, used topically and topically.
- Lyophilisate, intended for the preparation of a solution used subsequently locally and as an injection.
In addition, the medication is in the form of suppositories, however, they are not produced on an industrial scale, but are prepared by pharmacists in pharmacies according to a special prescription from a doctor. Instructions for use in gynecology suppositories "Lidaza" consider below.
pharmachologic effect
Hyaluronic acid is a specific substrate that is part of hyaluronidase. Hyaluronic acid, in turn, is a mucopolysaccharide, which consists of acetyl glucominase and hyaluronic acid.
Due to its viscosity, hyaluronic acid is of great importance to the human body. It is able to strengthen the intermediate spaces of connective tissue, thereby improving articular mobility. In addition, it helps resorption of hematomas, softens scars, reduces or eliminates contractures.
Under the influence of hyaluronic acid, the permeability of tissues improves, the movement of fluids in the spaces between the tissues is facilitated, tissue swelling is reduced. The best effectiveness of the medication is observed if you use it in the initial stages of pathologies. So it says in the instructions. Lidase injections in gynecology are also used.
Pharmacodynamics and pharmacokinetics
The movement of interstitial fluids and tissue permeability are stimulated by the breakdown of hyaluronic acid into two substances - glucosamine and glucuronic acid.
As the concentration of hyaluronidase decreases, the viscosity of hyaluronic acid is restored.
Indications for use
According to the instructions for Lidase, suppositories and injections can be used to treat a wide range of pathologies and specific symptoms. Its application is shown:
- With hemophthalmia.
- With neuritis and plexitis.
- In inflammatory processes localized in the upper part of the respiratory system and accompanied by obstructive processes.
- In order to eliminate hematomas of soft tissues that are localized on the surface.
- With a hyphema.
- With retinopathy.
- With myocardial infarction.
- With hydrocephalus.
- With skin diseases, with scleroderma.
- In diseases that affect the lumbar spine.
- With ankylosing spondylitis.
- In chronic tenosynovitis.
- For the treatment of osteoarthritis.
- With contracture of the joints that arose as a result of inflammation or trauma.
- For the treatment of ulcerative lesions with a prolonged healing period.
- With joint stiffness.
- With scars of various etiologies (resulting from surgery, trauma, burns).
Contraindications
As the instructions indicate, "Lidase" has a number of contraindications. This enzyme preparation should not be used for:
- vitreous hemorrhages;
- pulmonary hemorrhage;
- respiratory failure;
- any form of tuberculosis;
- regular hemoptysis;
- ongoing bleeding;
- malignant tumors;
- patient age up to 18 years;
- inflammatory and infectious pathologies in acute phases;
- intercurrent diseases in acute forms;
- previous hemorrhage;
- hypersensitivity to any component of the drug.
Side effects
Most often, patients tolerate Lidase very well, even if they have a sensitivity to the drug, and the diseases have a complex shape. In exceptional cases, an allergic reaction can occur, which manifests itself in the form of skin lesions.
Usage and Dosage
What does the instruction for Lidaza injections tell us? Injections with a solution are carried out in accordance with the following schemes:
- For the purpose of scar treatment, the drug is administered subcutaneously or intramuscularly. With intramuscular use, administration is carried out in close proximity to the affected area. If subcutaneous administration is expected, then the injection must be performed under the scar. The introduction is carried out every day, once, for up to 30 days. The drug is used in an amount of 1 ml. With shallow cicatricial lesions, the use of the drug every other day is permissible.
- In ophthalmology, the electrophoresis method with Lidase is used. Can be used to instill a solution of "Lidase" (0.1%). Therapy should be comprehensive and involves the parallel use of antibiotics.
- For traumatic lesions of the peripheral nerves, as well as plexuses of the nerves, subcutaneous administration directly to the lesion area is recommended. The medicine is used in an amount of 1 ml together with a solution of procaine. The procedures are carried out every other day, most often the course of therapy involves 15 injections.
- Tuberculosis and other pathologies of the respiratory system suggest the use of Lidase for inhalation and injection. If the case is severe, then both methods are used in combination. Inhalations are carried out for 25 days using 5 ml of the substance. In the absence of the necessary effect, the course should be repeated after 2 months.
- The use of "Lidase" in gynecology instruction recommends in the form of suppositories and injections. Candles are made according to the prescription in pharmacies; they are not available on sale. One should inject from one into the vagina every three days. The full course of treatment involves the introduction of 10 suppositories.
The solution can be used to soak dressings. We give instructions on how to breed Lidazu. To prepare the solution, mix boiled water, 10 ml of sterile sodium chloride (9%) and 1 ml of the drug. Mixing is carried out in a sterile container, where then a sterile dressing is placed for impregnation. Then it is applied to the affected area, covered with wax paper and fixed with a bandage.
It can also be used according to the instructions "Lidazu" for electrophoresis.
Not many people know how to prepare and use a solution for electrophoresis or phonophoresis. To prepare the solution, mix 300 IU of Lidase, 60 ml of distilled water, 5 drops of hydrochloric acid (0.1%). Dilution by buffer solution is admissible. The drug is injected into the affected area using the anode. The duration of such a procedure is no more than half an hour. The best therapeutic effect is achieved with 20 procedures.
Overdose
The instruction to "Lidase" explains in great detail that sometimes an overdose of a medication may occur. An overdose can occur in the form of such symptoms:
- Hives.
- Tachycardia.
- Changes in blood pressure.
- Vomiting.
- Nausea.
- Skin rashes.
- Puffiness localized at the injection site.
- Dizziness.
- Chills.
If at least one of the listed symptoms of an overdose is observed, the patient should immediately enter "Epinephrine", ensure the administration of GCS and antihistamines.
Interaction with other medicines
In accordance with the instructions for "Lidase", with parallel use, the effect of local anesthetics is enhanced. Often used to stimulate drug absorption.
Doctors recommend using the medication with caution in conjunction with other medicines, since an increase in absorption, which cannot be predicted, is not excluded. Increased systemic effects may be observed.
Analogs and cost
There are not many drugs similar in therapeutic effect to Lidase. Among them: “Ronidase”, “Lidase-M”, “Lidase” (for injections), “Hyaluronidase”.
The cost of Lidase injection is more than affordable. The average price may vary depending on the pharmacy and the region of sale, is about 20 rubles.
A set of lyophilisate and solution can cost about 250 rubles. The average price of Lidaza in the form of suppositories is 200 rubles.
Reviews about "Lidaz"
The vast majority of reviews of the drug indicate the high effectiveness of the drug, even despite the fact that the initial stages of treatment are accompanied by some side effects. However, over time, they decrease and then completely disappear, after which patients experience noticeable improvements. Subsequent examinations by specialists confirm that Lidase is really effective in treating, for example, adhesive processes.
Most often, doctors recommend Lidase in the form of a solution for injection, including in the field of gynecology. Patients in their reviews report that the first injections bring discomfort and even pain. However, doctors claim that this situation is normal and not dangerous.
Experts believe that Lidase is especially effective in the treatment of various gynecological pathologies. Despite the skepticism of many patients, the medication is actively prescribed and allows you to achieve the desired result.
It is also reported about the effective use of the drug for inflammation in medical cosmetology, in order to improve the absorption of medicines that are indicated to be administered under the skin or intravenously.
Separately, patients noted the excellent tolerability of the drug, its affordable price and affordability.
Despite the proven effectiveness and a large number of positive recommendations, one should not resort to the independent use of Lidase. The drug should be prescribed by a specialist who can eliminate contraindications and determine the feasibility of using this particular drug. Compliance with the doctor's recommendations will help to avoid the occurrence of overdoses, side effects, negative interactions with other medicines and unwanted reactions of the body.