Nimesil powder is a representative of a group of non-steroidal anti-inflammatory drugs. It refers to a chemical derivative of sulfanilamides. The medication is used to reduce the severity of inflammation and its signs in various pathological processes.
Structure
The drug is in the form of a powder for the manufacture of a suspension, which is intended for oral administration. It has a light yellow tint, large grain and orange aroma. The main active ingredient of the drug is nimesulide, its concentration in one powder sachet is 100 milligrams.
The product is packaged in bags of aluminum foil in 2 grams. In total, the package contains nine, fifteen and thirty sachets.
Pharmacological actions
The main component of Nimesil refers to the selective antagonists of the cyclooxygenase-2 enzyme that inhibit its activity. Cyclooxygenase accelerates the reaction of conversion of omega-6-unsaturated fatty acids into the main mediators of the inflammatory reaction - prostaglandins.
A decrease in the concentration of prostaglandins can lead to a decrease in signs of inflammation, which include pain, tissue swelling, and blood stasis in the capillaries of the microvasculature.
After using a suspension made from Nimesil, the main substance is instantly and completely absorbed inside the blood. The drug is evenly distributed throughout all tissues, where it has a pharmacological effect. The active substance is exchanged mainly in the liver with the formation of inactive products that are excreted in urine.
The elimination time from the body of half the dosage of the drug for nimesulide is approximately six hours.
Indications
Is it possible to "Nimesil" with a headache? Drinking a suspension that is prepared from powder is recommended to reduce the severity of the inflammatory process and pain in certain diseases and conditions, which include:
- Pain in the back, lower back.
- Pathological processes in the structures of the musculoskeletal system.
- Tendonitis (an inflammatory disease in the tendon. It can be both acute and chronic).
- Sprains.
- Dislocations (complete displacement of the articular ends of the bones relative to each other).
- Toothache.
- Migraine (a neurological disease, the most frequent and characteristic symptom of which is episodic or regular severe headaches).
- Dysalgomenorrhea (a pathological process in women, which is characterized by severe pain during menstruation).
Based on the evidence, "Nimesil" with a headache you can drink. But the powder for migraines is intended only for the complex and pathogenetic treatment of pain and inflammation. The drug does not have any effect on the main cause of the pathology.
Contraindications
The powder can not be used if the patient has the following pathological processes or physiological conditions:
- Duodenal ulcer.
- Gastrointestinal bleeding.
- Nonspecific ulcerative colitis (a chronic inflammatory disease of the colon mucosa that occurs as a result of the interaction between genetic factors and environmental factors).
- Febrile conditions.
- The presence of allergic diseases.
- Hypersensitivity (a complex of symptoms that occur in response to contact with certain substances due to impaired immune system function).
- Allergic bronchitis (inflammation of the bronchial mucosa, which occurs when the mucosa comes in contact with an allergen, which leads to its irritation).
- Inflammation of the nasal mucosa.
- Nettle rash.
- The recovery period after coronary artery bypass grafting.
- Pregnancy.
- Lactation (the process of formation, accumulation and periodic excretion of milk in humans and mammals).
- The patient's age is up to twelve years.
With special care, Nimesil powder is used for headaches in the following diseases and conditions:
- Diabetes mellitus (a metabolic disease characterized by chronic hyperglycemia that develops as a result of a violation of the interaction of insulin with tissue cells).
- Arterial hypertension (a disease in which sustained high blood pressure is noted).
- Ischemia.
- Chronic vascular disease with predominant damage to the arteries of the legs: gradual obliteration - narrowing of the vessels up to the complete closure of their lumen with the death of tissue deprived of blood supply.
- Smoking.
How to breed powder?
One sachet is dissolved in one glass of water with a volume of 100 milliliters. The finished mixture must be consumed immediately, it is not subject to storage.
The average pharmacological dosage is 100 grams of nimesulide (one sachet) twice a day. The maximum duration of Nimesil therapy should not be longer than fifteen days. Dose adjustment for adolescents over twelve years of age, people of retirement age, as well as people with concomitant mild renal failure, as a rule, is not required.
Adverse reactions
When using a suspension that is prepared from Nimesil powder, the appearance of negative phenomena from various organs and systems is possible:
- Nausea.
- Intermittent vomiting.
- Diarrhea (a pathological condition in which the patient has frequent bowel movements, while the stool becomes watery).
- Abdominal pain.
- Constipation (delayed, obstructed or systematically insufficient bowel movements).
- Flatulence (excessive accumulation of gases in the intestines. Manifested by bloating, abundant secretion of a large amount of digestive gases is possible).
- Hypertension (a disease in which sustained high blood pressure is noted).
- Tachycardia (increase in heart rate from 100 beats per minute).
- Sensation of hot flashes.
- Dizziness.
- Migraine (a neurological disease, the most frequent and characteristic symptom of which is episodic or regular severe pain).
- Nervousness.
- Hepatitis (inflammatory liver disease).
- Dyspnea.
What adverse reactions does the drug cause?
"Nimesil" at the wrong dosage can cause the following diseases:
- Bronchial asthma (chronic inflammation of the airways involving a variety of cellular elements).
- Hematuria (the presence of blood in the urine in excess of the values that make up the physiological norm).
- Dysuria (violation of the urination process).
- Visual impairment.
- Eosinophilia (a condition in which there is an absolute or relative increase in the number of eosinophils).
- Thrombocytopenia (a condition characterized by a decrease in the number of platelets below the standard, which is accompanied by increased bleeding and problems with stopping bleeding).
- Itching
- Skin rashes.
- Increased sweating.
- Urticaria (acute reaction of the body to an allergen).
- Quincke's edema (a reaction to the effects of various biological and chemical factors, often of an allergic nature).
- Anaphylactic shock (severe systemic allergic reaction of an immediate type, developing upon contact with foreign antigen substances).
The occurrence of any of the symptoms of adverse reactions after starting to use the suspension is the basis for stopping treatment.
Features
Does Nimesil help with headaches? Before starting therapy, you must thoroughly familiarize yourself with the instructions for use with the drug. There are several features of the correct use of Nimesil, which include:
- The active component of the drug can interact with drugs of other therapeutic groups, so when using them, you must consult a doctor.
- The possibility of the appearance of negative effects decreases with the use of the drug in the minimum dosage.
- Kidney disease of moderate severity requires a decrease in the concentration of an active trace element.
- An additional component of the drug is sucrose, which must be taken into account when prescribing to patients with diabetes.
- It is not recommended to use the powder in conjunction with other non-steroidal anti-inflammatory drugs.
- The effect of the drug on the activity of the nervous system has not been studied, therefore, when using Nimesil, special care should be taken when engaging in activities that require a quick reaction.
In drugstores, Nimesil is dispensed with a prescription from a medical specialist. You can not take the medicine yourself without a doctor's prescription.
Poisoning
A significant excess of dosing can provoke nausea, vomiting, apathy, drowsiness, abdominal pain, and gastrointestinal bleeding. Therapy of poisoning must be carried out in a hospital. It is symptomatic, as there is no special antidote for today. In addition, gastric and intestinal lavage are carried out, intestinal sorbents are used.
Substitutes
The following drugs are considered similar in structure and pharmacological action for Nimesil:
- Nimesulide;
- Nemulx
- "Kostral";
- Aponil;
- Mesulide;
- Nimulide;
- "Ameolin";
- "Aulin."
Storage conditions
The shelf life of Nimesil for headache is twenty-four months. The prepared suspension cannot be stored. The medication should be stored in a dry, inaccessible place for children at a temperature of no more than +25 ° C. The average price of a drug varies from 250 to 800 rubles.
Opinions
People are satisfied with the cost of the drug, the constant presence in drugstores, the speed of the drug. Among the negative opinions there are complaints of pain in the stomach with a small amount of water in the preparation of the suspension.
The drug is characterized by consumers as one of the few drugs that helped them. In most cases, Nimesil is well used for headaches and for acute viral diseases, flu, and colds.
Negatively speak about the appearance of severe sweating during therapy. Medical experts warn of a large number of adverse reactions that occur when the drug is improperly combined with other drugs, as well as diseases that are incompatible with Nimesil. And they warn against frequent use of medication for tolerable pain and low body temperature.
Does Nimesil help or not from a headache? In the reviews, patients talk about its increased effectiveness for severe headaches, as well as for pain in the back, legs, toothache, colds, and postoperative pain.