At the first symptoms of a cold, doctors recommend taking a shock dose of an analgesic right away. In the future, you need to maintain your immunity, and the infection will recede.
General information
What kind of analgesics do you know? If you do not know which drug should be taken with a cold, then we will help you with this.
The most common and popular remedy for the treatment of such diseases is the Maxicold medication. Instructions for the use of this medication, its contraindications, side effects and release forms will be discussed in this article.
Forms, composition, packaging and description
There are several forms of the drug in question. It can be purchased in the following forms:
- Maksikold oral medication (tablets). The instruction for use reports that such a medication has a pinkish-orange color, a film membrane and a biconvex oval shape. The active substances of this medication are paracetamol, ascorbic acid and phenylephrine hydrochloride. As auxiliary components, croscarmellose sodium, hyprolose (hydroxypropyl cellulose), calcium hydrogen phosphate, magnesium silicate, ethyl cellulose, talc, dye yellow "Sunny sunset" are used. The medicine is issued in cell packs and cardboard boxes, respectively.
- Crystalline substance "Maksikold" (powder). Instructions for use states that this drug has a specific smell and light yellow color. In it, the presence of white crystals and decaying lumps is permissible. After dilution, the solution opalesces and has a pleasant aroma of orange. The active components of this tool are also paracetamol, ascorbic acid and phenylephrine hydrochloride. In addition to them, the composition of the powder includes auxiliary ingredients (colloidal silicon dioxide, sodium citrate, sodium saccharin, potato starch, citric acid, lactose, flavoring, quinoline yellow dye). The medication in question is packaged in 5 g sachets (from a combination material) and sealed in cardboard boxes.
- Aerosol "Maxikold Lor" (spray). Instructions for use indicate that the medication in question is a transparent and almost colorless liquid that has a characteristic menthol odor. The active substance of this tool is hexetidine. As auxiliary components, sodium saccharinate dihydrate, glycerol, citric acid monohydrate, sodium hydroxide, lauromacrogol, ethanol, levomenthol, cineole, peppermint leaf oil and purified water are used. The spray goes on sale in aluminum aerosol cans with a metering pump, which is equipped with an atomizer for oral use and a protective cap.
Pharmacological properties
What is the MaxiCold Medication? Instructions for use indicate that it is a combination agent that has analgesic and antipyretic effects, designed to alleviate the symptoms of flu and colds.
According to experienced specialists, the effect of this drug is due to the properties of the substances that make up its composition.
- Phenylephrine is called an alpha-1-adrenostimulator, which practically does not affect beta-adrenergic receptors of the heart. Also, it is not catecholamine. This substance causes a narrowing of the arterioles, which greatly facilitates breathing, reduces hyperemia of the mucous membrane and swelling of the nasal cavity.
- Paracetamol is a non-narcotic analgesic. It has antipyretic and analgesic properties, which are caused by the blockade of cyclooxygenase in the central nervous system and the effect on the centers of thermoregulation and pain. This substance reduces the effects of fever, as well as muscle and headaches.
- Ascorbic acid enhances the body's resistance to infections, and replenishes the body's need for vitamin C, especially with flu and colds.
Pharmacokinetics
What kinetic parameters does the Miksikold drug have? Instructions for use states that each component of this product has its own absorption properties.
Paracetamol is absorbed from the intestines. Its maximum concentration is observed after 30-180 minutes. Communication with plasma proteins is 15%. The metabolism of this substance occurs in the liver. Its elimination half-life varies between 1-4 hours. The medication is excreted mainly through the kidneys.
After taking the drug inside, phenylephrine is poorly absorbed from the digestive tract. Its metabolism occurs with the participation of monoamine oxidase in the intestinal walls, as well as during the first passage through the liver. The bioavailability of phenylephrine is very low.
Vitamin C is absorbed from the digestive tract, mainly in the small intestine. Its highest concentration is observed after 4 hours. The drug quite easily penetrates into platelets and leukocytes, and then into all body tissues.
The maximum concentration of this substance is observed in glandular organs, the lens of the eye, white blood cells and the liver. It also crosses the placenta. The metabolism of ascorbic acid is carried out in the liver, where it is converted to oxaloacetic and deoxyacorbic acid and ascorbate-2-sulfate. Excretion of vitamin C occurs through the kidneys, intestines, sweat and breast milk.
Indications for use of spray, powder and tablets
For what purpose can the drug “Maxikold” (spray) be prescribed? The instructions for use state that all forms of the mentioned drug must be used for the symptomatic treatment of inflammatory and infectious diseases. Also, this tool is used for influenza and SARS.
Contraindications
What human conditions are forbidden to use the Maxikold Rino medication? Instructions for use indicate that any form of the drug in question is not prescribed for:
- arterial hypertension;
- renal and hepatic insufficiency (expressed);
- heart diseases (including acute myocardial infarction, severe stenosis of the aortic mouth and tachyarrhythmia);
- hyperthyroidism, as well as thyrotoxicosis;
- the simultaneous use of other drugs containing paracetamol, as well as drugs designed to relieve signs of flu, colds and nasal congestion;
- prostatic hyperplasia;
- simultaneous administration of monoamine oxidase inhibitors, beta-blockers and tricyclic antidepressants, including a period of 2 weeks after their withdrawal;
- angle-closure glaucoma;
- hypersensitivity to any of the substances of the drug;
- in children under 9 years old, and also with a weight of less than 30 kg.
With caution, this medication is recommended for pregnant women, people with a deficiency of glucose-6-phosphate dehydrogenase, as well as during breastfeeding, with benign hyperbilirubinemia and in old age.
The drug "Maxikold Rino": instructions for use
Powder for the preparation of a medicinal solution in the amount of 1 packet is poured into a glass of hot boiled water and thoroughly stirred until crystals are dissolved.
For adult patients, this drug is not recommended to be taken more often than every four hours. The maximum daily dose of this medicine is 4 packets per day.
Powder should be given to children every six hours and not more than 3 packets per day.
In order to avoid the development of adverse reactions, the drug in question is forbidden to be used for more than five consecutive days as an anesthetic and more than three days as an antipyretic.
Method of administration and dosage of tablets
At what dose are Maxicold tablets prescribed? The instruction for use reports that this medication is taken orally before a hearty meal or two hours after it (it is recommended to drink it with plain water).
For adolescents and adults, the drug is prescribed in the amount of 2 tablets every four or six hours.
The dose of the medicine for children 9-12 years old is 1 tablet with the same multiplicity.
According to experts, the medication in question is not recommended for more than five consecutive days for pain relief and more than three days to lower the temperature.
The drug "Maksikold" (spray): instructions for use
For children, an aerosol is prescribed only from three years old. In this case, the medication should be used only under the supervision of adults or a pediatrician.
So how should you use a tool like MaxiCold Lore? Instructions for use indicate that the drug in question is intended for local injection. Using an aerosol, all affected areas in the pharynx and oral cavity are treated. The procedures are carried out between meals.
How to inject the drug "Maksikold" (spray)? Instructions for use indicate the need to perform the following actions:
- remove the cap from the bottle and install the sprayer;
- when using the aerosol for the first time, it is required to make short pressures and direct the jet into the air;
- insert the nozzle into the oral cavity and press the sprayer 2-4 times until it stops (hold your breath).
Side effects
Now you know how to use MaxiCold Lor. Instructions for use were presented a little higher.
The use of the agent in question can contribute to the appearance of the following adverse reactions:
- violation of blood formation;
- migraine, nausea, decreased blood pressure, vomiting, increased blood pressure, irritability;
- angina pectoris, palpitations, bradycardia, dyspnea, ventricular arrhythmia, tachycardia;
- gastrointestinal mucosa irritation, glucosuria, hyperacid gastritis, microangiopathy, urticaria, hyperprothrombinemia, hyperoxaluria, insomnia, erythropenia, neutrophilic leukocytosis, thrombocytosis and others.