The drug "Ganaton" refers to the pharmacological group of drugs that lead to the activation of intestinal motility. The medicine is used for lesions of the upper intestines, accompanied by a decrease in wave-like contractions of the walls of the hollow organs.
Structure
According to the instructions for use, "Ganaton" is dispensed in the form of capsules coated with a film enteric coating. The tablets are round, milky and at risk on one side. The active trace element of the drug is itoprida hydrochloride, the concentration of which in one capsule is fifty milligrams. And also additional substances are included in the structure of the medicine, for example:
- starch;
- lactose;
- carmellose;
- magnesium stearate;
- anhydrous silicic acid;
- hypromellose;
- titanium dioxide;
- macrogol 6000;
- carnauba wax.
Tablets are packaged in blisters of seven, ten and fourteen pieces. The package can contain from one to five blisters with the appropriate number of capsules and instructions for use.
Pharmacological properties
The main active microelement "Ganaton" is considered to be itoprida hydrochloride, it increases intestinal motility. This therapeutic effect is due to the antagonistic action of the active substance on D2-dopamine nerve endings.
In addition, it inhibits the strain of acetylcholinesterase, which leads to an increase in the content of acetycholine in the intestine, which in turn leads to the stimulation of peristaltic movements of its walls.
Due to this therapeutic effect of itopride, hydrochloride enhances gastric emptying and the movement of food into the lower intestine.
According to reviews and instructions for use with Ganaton, tablets help to suppress vomiting and nausea caused by apomorphine.
After ingestion of the capsule, the active component is almost completely absorbed from the small intestine. When the active substance passes through the liver, half of its dosage is decomposed.
Itoprida hydrochloride is evenly distributed throughout all body tissues, in a small amount it enters the structures of the nervous system. And also the active substance passes into the fetus during pregnancy and into breast milk during lactation. It is metabolized in the liver with the formation of decay products, which are excreted in the bulk with urine by the kidneys. The elimination half-life is six hours.
Indications
According to the instructions for use with Ganaton, tablets are recommended for use in non-ulcer lesions of the stomach, including chronic gastritis, accompanied by flatulence, as well as dyspepsia, sensation of instant satiety, vomiting, pain and discomfort in the upper abdomen, lack of appetite and heartburn.
Contraindications
Take Ganaton capsules is prohibited in a number of pathological and physiological conditions of the body, which include:
- Individual intolerance.
- Increased sensitivity to the substances in the drug.
- Gastrointestinal bleeding.
- Intestinal obstruction.
- Perforation of the wall of the stomach or intestines.
- Forming a through hole.
- Pregnancy.
- Age to sixteen years.
With extreme caution, the medication is recommended for patients for whom an increase in the level of acetylcholine can affect the course of the concomitant disease. Before using the medicine, it is important to make sure that there are no contraindications.
Mode of application
According to the instructions for use, "Ganaton" 50 mg must be taken orally, regardless of food intake. The average therapeutic dosage should be one hundred and fifty milligrams per day, which can be divided into three doses (one tablet three times a day). The duration of treatment is determined individually. For patients of retirement age, the daily dosage is reduced.
Adverse reactions
According to the instructions for use with the drug "Ganaton", the use of a drug can contribute to the appearance of adverse events in the body, these include:
- Nausea.
- Pain in the abdomen.
- Diarrhea.
- Increased salivation.
- Migraine.
- Dizziness.
- Hand shake.
- Thrombocytopenia (a condition characterized by a decrease in platelet count below standard indicators, which is accompanied by increased bleeding and problems with stopping bleeding).
- Leukopenia (a decrease in the level of white blood cells in a person’s blood below the standard).
- Hyperprolactinemia (a condition in which the level of the hormone prolactin in the blood is elevated).
- Gynecomastia (breast enlargement).
- Redness of the skin.
- Hives.
- Quincke's angioedema (an acute condition characterized by the rapid development of local edema of the mucous membrane, subcutaneous tissue and the skin itself).
- Anaphylactic shock (acute pathological condition that occurs with repeated penetration of the allergen).
If side effects occur, discontinue therapy.
Features
Before you start using the drug, it is important to carefully read the instructions for use for the drug "Ganaton". There are several features regarding its use, for example:
- Caution is needed to take medication for patients with diseases of the nervous system, in which an increase in acetylcholine levels can greatly affect the pathological process.
- The use of tablets during pregnancy in the late stages is sometimes permitted only as prescribed by the doctor, if the expected positive effect for the expectant mother exceeds the potential threat to the fetus.
- With increased intestinal motility, the drug may adjust the absorption rate of other drugs if they are taken concurrently.
- Cholinolytic drugs can reduce the pharmacological effect of Ganaton.
- The drug does not affect the speed of psychomotor reactions and attention.
In drugstores, the drug is sold only by prescription. If you have questions or doubts, you should consult with a medical professional.
Generics
It can be argued, based on the instructions for use for "Ganaton", the analogs of the tablets are similar both in active microelement and in pharmacological action:
- "Brulium Lingvatabs".
- Itopra.
- Tropisetron.
- Domidon.
- Motilak.
- Domperidone
- Motilium.
- Passasics.
Motilium
A broad-spectrum antiemetic that blocks dopamine nerve endings. Motilium is produced in the form of biconvex round milk-colored tablets coated with a film coating.
The medicine is very quickly absorbed from the gastrointestinal tract, reaching a high plasma content sixty minutes after ingestion. Motilium is characterized by a very low bioavailability - only fifteen percent. With low acidity, the absorption of domperidone decreases.
The active substance binds to blood proteins by ninety-three percent, extensively spreading through tissues, but, unfortunately, weakly concentrating in the brain.
It is excreted together with feces at sixty-six percent and with urine at thirty-three percent, unchanged. The half-life of the drug is from seven to nine hours. In people who suffer from kidney failure, this rate rises. The cost of the drug is 400-700 rubles.
Motilak
The spectrum of the drug is determined by the interaction of antagonism to dopamine nerve endings. Under the influence of Motilak, the time of peristaltic contractions increases in the antrum of the stomach and duodenum, in case of slowing down, the emptying of the stomach increases, the tone of the sphincter increases, and nausea and vomiting are eliminated. Motilak is made in the form of tablets.
Resorption capsules are recommended to be used before meals, for fifteen to twenty minutes. Adults and children over five years of age with dyspeptic symptoms need to take the medicine three to four times a day, ten milligrams. The cost of the drug is 250 rubles.
Domperidone
The medication is dispensed from pharmacy points in the form of tablets for oral use, which are coated with a protective film coating. Capsules are convex on both sides of a milky shade. Domperidone is packaged in blisters of ten tablets, all in a package from one to five pieces.
The medicine is prescribed to receive one capsule one to three times a day thirty minutes before meals. "Domperidone" is recommended to be swallowed immediately, washed down with water. With frequent nausea and vomiting, a drug is prescribed for taking two tablets three to four times a day under the supervision of a doctor.
For patients with kidney disease or liver failure, the daily dosage of the medication is selected individually by a medical specialist. The duration of therapy is determined by the doctor depending on the severity of the disease.
"Domperidone" is allowed to take children whose weight exceeds twenty kilograms, but not less than one year old. The cost of the medicine is 120 rubles.
Passasics
Tablets must be taken orally, preferably thirty minutes before a meal, because food slows down the absorption of the active ingredient. Adult patients, depending on the appointment of a specialist, are advised to take ten milligrams three times a day for chronic dyspepsia and, if necessary, before going to bed.
In severe conditions, which are accompanied by nausea and vomiting, twenty milligrams are prescribed three times a day. Children from five years old, depending on the doctor’s prescriptions, are recommended to use two and a half milligrams per ten kilograms of weight three times a day for chronic dyspepsia. The price of the drug is 250 rubles.
Storage conditions "Ganaton"
The average cost of Ganaton tablets depends on their quantity:
- Ten tablets - 300 rubles.
- Forty pills - 600 rubles.
- Seventy tablets - 900 rubles.
The shelf life of the drug is sixty months from the date of manufacture. It is important to keep the drug in a dark, dry, inaccessible place for children at a temperature of no more than twenty- five degrees, according to the instructions for use with the Ganaton.
Reviews
Ganaton analogs, like the drug itself, are evaluated on the positive side. The medication does a great job of heartburn and gastritis pain, vomiting, flatulence. Capsules are small in size, so they are convenient to use. Of the minuses, patients indicate a high price of the drug.