The prostate, or prostate, is located under the bladder. She takes an active part in the work of male genital organs, is responsible for erection, and also synthesizes the substances that make up sperm. Malfunctions in the work of this body significantly reduce the quality of sexual life, increase the risk of infertility and lead to hormonal failure. Most often diagnosed with prostatitis and adenoma. The first is an inflammatory process, and the second is a benign neoplasm in the gland. The article will consider which drugs for the treatment of prostate adenoma are used in medical practice.
Properties of drugs used to treat prostate tumors
Conservative therapy often involves taking several medications with the following properties:
- Removal of inflammatory processes that are able to intensify pain during urination.
- Normalization of the hormonal background.
- Improving immunity and improving the condition of the individual.
- Decreased urethral tone.
It is important to remember that drug therapy is prescribed only by the attending urologist after a full examination and diagnosis.
Symptoms of prostate adenoma in men
Drug treatment is especially effective in the early stages of the development of the disease. In order to timely identify the pathology, it is necessary to know its signs:
- To release urine, you have to push.
- The jet during the outflow of urine is intermittent.
- Concerned about the frequent urge to urinate, including at night.
- In case of overflow of the bladder, which is characteristic for the late stage of the disease, the individual is not able to hold it.
- Not all urine is excreted during urination, part of it is retained in the bladder. As the disease develops, its volume increases, which contributes to the development of the inflammatory process, which is a frequent companion of adenoma.
An increase in a prostate neoplasm of a benign nature provokes the occurrence of stagnation. The prostate gland in the presence of adenoma is more prone to prostatitis.
Symptoms of Prostatitis
The disease can be infectious and non-infectious in nature, as well as acute or chronic. In the first case, the clinical picture is as follows:
- pain in the inguinal region;
- inability to completely empty the bladder;
- frequent urination;
- temperature rise;
- weakness;
- small daily volume of urine;
- pain in the perineum, aggravated by outflow of urine or bowel movement.
In the second case, the symptoms are as follows:
- a feeling of incomplete emptying of the bladder, but at the same time frequent urges;
- discomfort in the perineum caused by pain, which intensifies during urination;
- decreased libido.
Prostatitis therapy
For the treatment of prostatitis, the most effective and modern are medicines that have the following dosage forms:
- Tablets and capsules - they are taken orally. Preparations in this form of release have an analgesic and a wide antibacterial spectrum of action, regulate the functioning of the genitourinary system.
- Suppositories - they act in close proximity to the lesion, providing an analgesic and anti-inflammatory effect.
- Solutions for injection - they are administered intravenously or intramuscularly and are used for severe intoxication.
- Microclysters with a decoction of St. John's wort, calendula, chamomile, motherwort or with sea buckthorn, sunflower, peach oil.
Doctor's recommendations: in what cases is pharmacotherapy indicated?
Medications for the treatment of prostate adenoma are recommended as both primary and secondary therapy. When they are prescribed, the condition of the individual, the features of the manifestations of the disease, as well as contraindications for taking medications, are taken into account. Indications for medical treatment are:
- The inability to perform surgical intervention.
- The absence of complications from the renal system.
- Re-occurrence of a benign mass after surgery.
Pharmacotherapy is prescribed at the first stage of the onset of pathology, that is, during the period when the dysfunction is minimal and there are no complications that adversely affect the work of the kidneys. And also if there are contraindications to surgical treatment, such as problems with the cardiovascular system and the advanced age of the individual. Currently, about 80% of men receive treatment for prostate adenoma without surgery. Preparations of different pharmacological groups do an excellent job with this problem:
- 5-alpha reductase inhibitors - “Prosteride”, “Avodart”, “Alphinal” help to cope with the symptoms of the disease, are effective for large tumors.
- Hormones - "Sustanon", "Prostatilen" are not prescribed to all patients.
- Alpha-adrenergic blockers - "Adenorm", "Omnic", "Lokren" relax the muscles of the prostate and normalize urination.
- Antibiotics - "Gentamicin", "Levorin" are indicated when an infection of a bacterial nature is attached.
- Herbal remedies - “Prostagut”, “Tykveol”, “Trianol” improve the process of outflow of urine, relieve swelling, and remove inflammation.
Contraindications to medication
Pharmacotherapy is not carried out in the following cases:
- Bladder stones
- The volume of residual urine is more than 100 ml.
- Acute urinary retention.
- Serious violations of the outflow of urine.
- Hematuria, i.e. the presence of blood in the urine.
Preparations for the treatment of prostatitis and prostate adenoma
The following groups of medicines are used to eliminate the causes and signs of prostatitis and adenoma:
- Antibiotics - Summamed, Azithromycin, Amoxicillin, Oxytetracycline, Ofloxacin, Levofloxacin.
- NSAIDs - Nimesil, Ibuprofen - relieve pain, inflammation and temperature.
- Relaxants - “Midokalm”, “Drotaverin” relieve the tone and motor activity of smooth muscles.
- 5-alpha-reductase inhibitors - "Alphinal" reduces the negative effects of androgens on the gland.
- Alpha-adrenergic blockers - Tamsulosin weakens the smooth muscles of the neck of the bladder, also the urethra. As a result, pain disappears.
To improve blood flow in the pelvis, Pentoxifylline and Vinpocetine drugs have proven themselves well. To strengthen the body and the immune system, such drugs as Fitadiol and Combibipen are indicated.
Alpha1-adrenergic antagonist drugs
They relax the smooth muscles of the organs entering the urinary system and improve the outflow of urine. The most famous and effective of this group is the Omnic drug. In the treatment of prostate adenoma, capsules and tablets are used. The last dosage form is more progressive, as it provides a gradual release of the active active substance tamsulosin. As a result, it enters the blood evenly and is in the body of the individual in constant concentration.
Omnic does not affect vascular tone, has a small number of undesirable reactions and is approved for use by patients suffering from chronic hypertension. The drug selectively acts on the alpha1-adrenergic receptors of muscles located in the prostate, bladder and prostatic urethra. Relaxing muscle tone improves urine output and relieves some of the unpleasant symptoms of prostate adenoma in men. Treatment with Alfuzosin, Urorek, Omsulosin, Tamzelin, Sonizin, where the active ingredient is tamsulosin, allows for a long period of time:
- Reduce the risk of surgery.
- Reduce the risk of acute urine retention.
- Remove the severity of signs of filling and emptying of the bladder.
Medicines of this group due to lower peripheral resistance can reduce pressure. This fact should be taken into account when prescribing these drugs to patients with hypertension. A properly selected dose of the drug minimizes undesirable effects and gives a good therapeutic effect.
Medicines included in the group of reductase inhibitors
The most famous drugs for the treatment of prostate adenoma in men:
- "Avodart" - inhibits the activity of isoenzymes responsible for the conversion of the hormonal substance testosterone into five alpha-dihydrotestosterone. The latter is responsible for the proliferation of glandular tissue in the prostate. The effectiveness of the treatment is evaluated two weeks after the start of treatment.
- "Dutasteride" - reduces the risk of acute delay in urine and improves its outflow. As a result, the need for surgical treatment is removed.
- “Finasteride” is a drug for the treatment of prostate adenoma, in which the active substance helps to block the conversion of testosterone to a more active hormone called dihydrotestosterone. As a result, the concentration of the latter decreases in the tissues of the prostate and in the blood serum. The volume of the gland decreases, the rate of urination increases, the signs of the disease become less pronounced.
- "Penester" - the effect of the drug is similar to the previous one.
- “Alfinal” - this drug for the treatment of prostate adenoma belongs to antitumor hormonal medicines. Thanks to the use of this drug, the stimulating effect of testosterone on the development of the tumor process is blocked. With regular use, the effect is visible after three months - the volume of the gland decreases, after four - the maximum speed of the outflow of urine increases, and after seven - the general signs of pathology, as well as symptoms of obstruction of the urinary tract are reduced.
"Finasteride" and "Dutasteride" in the treatment of prostate adenoma
These are effective drugs for treating prostate adenomas that inhibit the cellular enzyme to prevent the conversion of testosterone to a more active form. It is this transformation that causes the enlargement of the prostate gland. Reception of "Finasteride" or "Dutasteride" is indicated for:
- Reduce the risk of surgical therapy.
- Improvement in urination.
- Eliminate the occurrence of acute urine retention.
- Removing signs of the disease.
- Control of prostatic hyperplasia.
Due to the fact that these drugs reduce the concentration of male hormones in the blood, they should be taken carefully, i.e. strictly according to the recommendation of the treating urologist.
Painkillers and antispasmodics for exacerbation of prostate adenoma
Among the honey. preparations for the treatment of prostate adenoma in the acute stage, experts prefer:
- NSAIDs - Ibuprofen, Diclofenac, which have an analgesic and anti-inflammatory effect. They well relieve unpleasant pain during urination, as well as constant pain in the perineum, in the groin. Taking medications of this pharmacological group helps to cope with the symptoms of the disease, lower the temperature, reduce the inflammatory process, and remove swelling of the gland.
- Analgesics are drugs for the treatment of prostate adenoma, which can remove pain. They are used in different dosage forms - tablets, suppositories. The simplest and most affordable is Metamizole Sodium, which is known to everyone under the trade name Analgin. Combined agents are also effective, for example, Procto-Glivenolum, Ichthyolum.
Conclusion
After reading the article, you got acquainted with the best drugs for the treatment of prostate adenoma, as well as their pharmacological action and release form in accordance with the official instructions for medical use. Modern drugs can prevent the need for surgery and stop the growth of the prostate gland. It is important to remember that self-treatment of this ailment is not only ineffective, but also dangerous for men's health.