"Pancreatin" (lat. Pancreatin) - an enzyme-containing preparation, which is obtained from pancreatic secretion formed in the pancreas of cows or pigs. Pancreatin is a non-crystalline light powder, usually grayish or yellowish in color, it is poorly soluble in water, has a slightly specific smell. It is found in many drugs that are used to improve the digestibility of food. A similar drug to Pankeatin is Pancytrate.
Tablets "Pancreatin": instructions for use
Pharmacological properties. The tablets contain certain enzymes, such as alpha-amylase, trypsin, lipase, chymotrypsin. The medicine "Pancreatin" is used to facilitate digestion, since the substance contained in it helps to break down fats to fatty acids or glycerol, proteins to amino acids, starch to monosaccharides or dextrins. Pancreatin tablets are coated with a protective coating that prevents them from breaking down inside the stomach. Pancreatin is absorbed in an alkaline environment when it enters the small intestine.
The use of the drug "Pancreatin". It is used for disorders of the natural functioning of the pancreas: Remkheld’s syndrome, cystic fibrosis, dyspepsia, chronic pancreatitis, pancreatectomy, cholecystitis, flatulence, gastritis, digestion disorders, duodenitis, diarrhea, intestinal infections, various diseases of the liver and bile ducts. It is often used before diagnostic tests of the gastrointestinal tract, for example, before an ultrasound or X-ray, in order to reduce the amount of gas formation.
Dosage. The dose of the drug is determined taking into account the age, as well as the degree of enzyme deficiency. The daily norm for an adult is about 150,000 units, with acute failure 400,000 units, for children from 50,000 to 100,000 units. lipases. The duration of treatment varies (it can be used for several days or a couple of years). Pancreatin tablets are taken at or before meals, and cannot be chewed. Drink preferably alkaline liquid (fruit juice, water). The maximum concentration of pancreatin in the body occurs after 35-40 minutes. With especially long-term use of the drug "Pancreatin" it is recommended to additionally drink a course of drugs with iron. Before taking a consultation with a doctor is required.
Interaction. A strong decrease in the effectiveness of the drug was found when used together with antacids that contain calcium carbonate or magnesium hydroxide. Iron absorption worsens when taken with iron-containing drugs.
Contraindications Pancreatin tablets are contraindicated in people with hypersensitivity or individual intolerance to pork, in the presence of acute pancreatitis, one of the hepatitis or in acute forms of chronic pancreatitis. Pancreatin tablets should be used very carefully during pregnancy or while breastfeeding, as the result may be unpredictable.
Special recommendations. In the presence of cystic fibrosis, it is not recommended to take more than 10,000 units per day. Also, there is a high probability of constipation in children.
Side effects. With strict adherence to the doses of the drug, side effects are very rare (about 1% of cases). The main side effects are: diarrhea, constipation, nausea, discomfort, abdominal pain, perianal irritation. Sometimes redness appears on the skin. With long-term use of the drug, hyperuricosuria, an increase in the amount of uric acid in the blood plasma can be observed.
The most common medications containing pancreatin:
- "Festal" (6000 units of lipase);
- Digestal (6000 units);
- Penzital (6000 units);
- Creon (8000 | 25000 units);
- Mezim-Forte (3500 | 10,000 units);
- Panzinorm (10,000 | 20,000 units);
- Mikrazim (10,000 | 25,000 units);
- Hermitage (10,000 | 25,000 | 36,000 units);
- Enzistal (6000 units).