High plasma cholesterol contributes to the development of atherosclerosis and heart disease.
For lipid-lowering treatment, special means are used, one of which is the Atokor drug. The instruction for this medication describes its hypocholesterolemic and hypotriglyceridemic role in reducing the concentration of harmful cholesterol and other fats in the human body.
general characteristics
The medicine refers to 3-methylglutaryl-3-hydroxy-coenzyme A reductase inhibitors. Manufactured by the Indian company Dr. Reddy's Laboratories.
The drug "Atokor" dosage can be 0.020 and 0.010 g.
Release form
The product is produced in tablet form with a film white coating. The tablets are squeezed in the form of a triangle with biconvex surfaces, one of which has the letter "A", and the other has a dose designation of "10" or "20".
Structure
The active ingredient of the drug is atorvastatin, which is represented by micronized calcium trihydrate. At Atokor, the dosage and composition of the quantitative active ingredient are slightly different. Each 0.01084 or 0.02168 g of atorvastatin calcium trihydrate is equivalent to 0.01 or 0.02 g of pure atorvastatin.
Milk sugar, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate formed the structure of the tablet.
The film shell is formed from 15 cps hypromellose, propylene glycol, purified talc, titanium dioxide.
The composition of Atokor is the same for both dosages, and their instructions are common.
Tablets of 0.01 or 0.02 g are produced in 10 pieces in a blister packaged in a cardboard box.
Mechanism of action
The medicine for use refers to selective, competitive inhibitors of 3-methylglutaryl-3-hydroxy-coenzyme A reductase. It is an important enzyme compound for the conversion of 3-hydroxy-3-methylglutarylcoenzyme A to the mevalonic acid, which precedes styrenes and cholesterol.
If patients have hypercholesterolemia of homozygous, heterozygous, familial and non-familial types, as well as mixed dyslipidemia, then taking the Atocor medication helps to reduce the concentration of total cholesterol, cholesterol particles found in low and very low density lipoproteins, triglycerides and apolipoproteins B.
Atokor drug description of the drug indicates the ability of tablets to unstably increase the level of useful sterol in high density lipoproteins.
In liver cells, triglyceride and cholesterol molecules become an integral part of lipoprotein substances having a very low density. They are sent to the plasma, with which they penetrate the peripheral tissue. Low-saturated lipoprotein compounds are formed from them, which can be catalyzed by interaction with high-affinity receptor formations. All of these substances can enhance the development of atherosclerosis.
The action of atorvastatin is characterized by a pronounced and persistent increase in the effectiveness of LDL receptor complexes, a decrease in the concentration of harmful cholesterol with increased cholesterolemia of a homozygous hereditary species.
Means "Atokor" instruction indicates its ability to lower plasma levels of cholesterol and lipoprotein due to inhibition of HMG-CoA reductase enzyme. It slows the formation of cholesterol in the liver cells, increases the number of receptor formations of lipoproteins with low saturation in the cell membranes. This enhances the uptake and catabolism of cholesterol molecules from low concentration lipoproteins.
Why use
Atokor Medication recommends taking the pill with the primary signs of increased cholesterolemia of the heterozygous type, local and non-local increase in the concentration of cholesterol, mixed heterlipidemia, an increased number of plasma triglyceride molecules.
They are prescribed in combination with dietary prescriptions to lower high cholesterol in low saturated lipoproteins, apolipoproteins B and triglyceride compounds.
Tablets reduce the plasma concentration of cholesterol in LDL with high cholesterolemia of the homozygous family type, when dietary nutrition and other non-pharmacological methods are ineffective.
How to use
Atokor medication recommends drinking only after prescribing to a sick person a standard hypocholesterolemic diet, which should be used during therapy. Dosage is set for each patient separately, which is calculated by the initial level of cholesterol in low saturated lipoproteins. It is important to consider the purpose, the effectiveness of therapy with the Atokor drug, and indications.
Typically, the initial dosage is equal to 0.010 g per dose per day. The use of tablets does not depend on the time of day or the use of food.
The daily dosage dosage from 0.010 to 0.080 g is selected based on the initial indicators of bad cholesterol, target conditions and personal effectiveness. At the initial stage of application and with an increase in the concentration of the drug, the level of plasma fats should be checked after half a month, and if necessary, adjust the dose.
Primary hypercholesterolemia and combined hyperlipidemia are treated with a daily dosage of 0.010 g.
Therapeutic activity occurs after 14 days, and maximum effectiveness is possible after one month. Long-term use allows you to save a therapeutic effect.
Medications "Atokor" instruction in Russian contains information on the treatment of hypercholesterolemia by homozygous family type. Usually, a daily dosage of 0.080 g is prescribed. With this application, the cholesterol value in LDL is reduced to 40%.
Treatment features
On Atokor tablets, the instructions for use strongly recommend that, before starting to use the drug, the cause of the secondary increase in cholesterol should be found. Such factors include poor therapy for diabetes mellitus, hypothyroidism, nephrotic process, dysproteinemic changes, obstructive liver disease. This may include treatment with other drugs and alcohol dependence. Only after getting rid of the above reasons, you can start using Atokor tablets.
Even before therapy, a lipid balance is determined between total cholesterol, cholesterol in LDL, in HDL and triglycerides.
There is no data on the use of the drug in pediatric practice, so these tablets are not prescribed for children.
In the treatment of elderly patients, whose age is more than 60 years, there is an increase in the plasma level of the active component of the drug to 40%.
In case of impaired renal function, it is not necessary to adjust the dose, since this condition does not affect the atorvastatin content in the bloodstream and the effectiveness of reducing harmful cholesterol.
There is evidence that the use of drugs of this class cause the development of rhabdomyolysis myopathy and insufficient kidney function in acute form. With such diseases, the medication should be abandoned for a while.
Atorvastatin-based drugs must be taken carefully to people who abuse alcohol or have had liver disease in the past.
Under the action of inhibitors of the HMG-CoA reductase enzyme, changes in the biochemical parameters of the liver are possible. For the timely installation of such disorders, it is necessary to evaluate the liver activity before treatment, and then, after 3 months after taking the tablets, re-check.
Atokor medication instructions in Russian include information on a marked increase in the plasma value of the active ingredient in patients with liver diseases who suffer from alcoholism. Temporary or complete refusal of therapy returns transaminase activity of the liver to its original framework. Many patients have not been canceled the use of the drug in small doses, and no adverse reactions have occurred.
During treatment, a dizziness may develop, a drowsy state may develop, therefore, while using the tablets, patients are prohibited from driving vehicles or other complex devices.
Who should not be used
Contraindications to the Atokor drug include hypersensitivity to each ingredient in the medication.
It is not taken in acute liver diseases and with high activation of transaminase serum enzymes, when their activity is 3 times higher than the upper limit of normal values.
The drug is not prescribed for women of reproductive age who do not use adequate contraceptives. Contraindication is the state of bearing a child and breastfeeding.
The medicine does not treat children and adolescents under the age of 18 years.
Due to the presence of milk sugar in the composition of Atokor tablets, the instructions for use prohibit their use for hereditary intolerance of galactose molecules, with a lack of lactase and malabsorption of galactose-glucose.
Analogs
There are a large number of atorvastatin-based drugs. The hypocholesterolemic role is assigned to the Atokor preparation by instructions for use. Analogs are also able to lower the level of bad cholesterol in human blood.
One of these medicines is the Atoris Slovenian medicine, which is manufactured by the joint-stock company Krka, Novo mesto. Available in the form of tablets with an active ingredient content of 0.010 g, 0.020 g, 0.040 g.
The medicine is intended to eliminate the hyperlipidemic state, in which it is necessary to reduce the total cholesterol, cholesterol in lipoprotein compounds with low saturation, the amount of apolipoprotein and triglyceride molecules in the bloodstream.
The drug treats people with hypercholesterolemia of a polygenic, heterozygous homozygous family type.
With the help of Atoris, the concentration of cholesterol in high saturation lipoproteins is increased.
Another Slovenian counterpart is the drug Tulip, which is produced by the Lek Pharmaceutical Company. There are three dosages of film-coated tablets: 0.01 g, 0.02 g and 0.04 g each.
The drug is prescribed to eliminate the primary form of hypercholesterolemic and combined hyperlipidemic conditions, for the treatment of increased cholesterol of a heterozygous and homozygous family type.
A similar remedy is considered to be the Indian medicine "Astin", which is produced by the company "Micro Labs Limited". Available in two doses: 0.010 g and 0.020 g of atorvastatin.
The drug is prescribed for increased lipid content, when there is no positive effect of dietary nutrition and other activities.
Indian production is the medicine "Storvas" based on the calcium salt of atorvastatin. It is produced by Ranbaxi Laboratories Limited in the form of a tablet with a shell coating in two dosages: 0.010 g and 0.020 g each.
The medicine “Storvas” reduces the increased content of total cholesterol, cholesterol molecules in LDL, the concentration of apolipoprotein and triglyceride compounds in the primary, heterozygous familial and non-familial hypercholesterolemic state, as well as in mixed hyperlipidemic disease.
The medication reduces the possibility of developing myocardial infarction, strokes, and changes in cerebral circulation. Tablets slow the progression of coronary atherosclerosis.
The American counterpart is Liprimar, which is manufactured by Pfizer. It is available in the form of coated tablets in three dosages: 0.010 g, 0.020 g, 0.040 g each. The drug is also used to eliminate the hypercholesterolemic state of different types of origin.
Reviews
The medicine "Atokor" describes the instructions for use as a tool with high proven effectiveness. Many patients suffering from an increased concentration of plasma harmful cholesterol, after course use, get better. The values of total cholesterol, as well as LDL, are reduced to a normal level, at which the likelihood of developing an atherosclerotic and ischemic condition decreases.
The drug refers to drugs with good tolerance, but in some patients it can cause stool retention, bloating, pain in the abdomen, nausea, and digestive upset. There are headaches, sleep disturbance. A convulsive, asthenic, and myalgic state may develop.
In rare cases, side effects are manifested by myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, hepatitis, cholestatic jaundice.
Tablets can cause anorexia, vomiting, hepatotoxic manifestations, alopecia, itchy manifestations in the form of a rash, impotence, cataracts, hyper- or hypoglycemia.