In the article, we consider the instructions for the Zoflox tablets. The drug refers to antimicrobial medicines. It has a fairly wide spectrum of action. Its bactericidal properties are explained by the fact that it is able to block the enzyme DNA gyrase of pathogenic microorganisms.
Release form
Dosage forms in which this medicinal product is produced:
- Pills, white and elongated with transverse risk, coated. Pack 5 or 10 pieces in blisters, one blister in a cardboard box.
- The solution for infusion - from light yellow to colorless, transparent. Poured into colorless glass bottles of 100 ml, one bottle in a cardboard box.
The composition of the drug
According to the instructions for use with Zoflox tablets, the medication contains the main active substance ofloxacin (200 or 400 mg each), as well as minor components: lactose, starch, hydroxypropyl cellulose, sodium carboxymethyl cellulose, magnesium stearate.
The composition of 100 ml of the solution for infusion included the main substance ofloxacin in an amount of 200 mg, as well as auxiliary elements - hydrochloric acid, water, sodium chloride.
pharmachologic effect
As the instructions for use indicate, Zoflox is a broad-spectrum antimicrobial drug from the class of fluoroquinolones, which affects the bacterial enzyme, DNA gyrase, produces a pronounced bactericidal effect. The main active substance of the drug is active against microorganisms that produce beta-lactamases, as well as atypical mycotic bacteria. The following types of bacteria are sensitive to the effects of a drug:
- Escherichia coli;
- Bordetella pertussis;
- Stafhylococcus epidermidis;
- Neisseria meningitides;
- Enterobacter spp .;
- Proteus spp .;
- Hafnia;
- Bordetella parapertussis;
- Vibrio parahaemolyticus;
- Staphylococcus spp .;
- Salmonella spp .;
- Campylobacter jejuni;
- Aeromonas hydrophila;
- Vibrio cholera;
- Legionella spp .;
- Haemophilus ducreyi and others.
On Treponema pallidum, this medication does not work.
Pharmacokinetic properties
In accordance with the instructions for use with Zoflox, after oral administration of the medication, complete and rapid absorption of the main substance is observed. Communication with plasma proteins is 24%, bioavailability is 97%, it takes 1 to 2 hours to reach maximum concentration. The maximum concentration directly depends on the dosage of the drug.
Food does not affect the bioavailability of the drug, but may slow its absorption. After a single intravenous infusion, after 60 minutes (with a dosage of ofloxacin 200 mg), the maximum concentration in the blood is 2.8 μg / ml, and after 12 hours - 0.3 μg / ml. Equilibrium concentration is achieved after the introduction of four doses. The distribution of the active substance occurs in the respiratory system, soft tissues, skin, bones, bile, pelvic organs, urine, prostate secretion, and saliva. The medicine penetrates well through the placental barrier and can be excreted in breast milk. It is also able to penetrate into the cerebrospinal fluid.
Metabolism of the substance occurs in the liver with the formation of N-oxide ofloxacin and dimethylofloxacin. The half-life of the dosage is independent and is in the range from 5 to 8 hours. It is excreted, as a rule, by the kidneys unchanged (up to 90%), as well as with bile (about 5%).
What else does the instruction for Zoflox tell us?
Indications for the appointment of the drug
The drug is prescribed for the following pathologies:
- infectious and inflammatory diseases of the kidneys, urinary, genital and biliary organs (pyelonephritis, cystitis, urethritis, endometritis, salpingitis, colpitis, orchitis, oophoritis, cervicitis, epididymitis, parametritis, prostatitis);
- infections of the respiratory and ENT organs, joints, bone tissue, skin (bronchitis, laryngitis, pneumonia, pharyngitis, sinusitis, otitis media;
- meningitis;
- gonorrhea, chlamydia;
- septicemia (solution for infusion);
- prevention of infectious pathologies in people with impaired immunity.
Contraindications
Instructions for use with Zoflox indicate that the absolute contraindications to the use of this medication are:
- glucose-6-phosphate dehydrogenase deficiency;
- reduction of the convulsive threshold, as well as the state after head injuries, strokes and inflammatory diseases of the central nervous system;
- epilepsy (history);
- lactation, pregnancy;
- the presence of intolerance to the components in the composition of the drug.
Use of the drug with caution
Also, the instruction for Zoflox (400 mg, 200 mg) reports that caution when using the medicine is required in the case of the following conditions and diseases:
- organic lesions of the central nervous system;
- cerebral arteriosclerosis;
- chronic renal failure;
- circulatory disorders in the brain;
- children under 18 years old.
Dosage and route of administration of the drug
The dosage of the drug in each case will be determined individually by the doctor. The medicine is prescribed taking into account the severity and localization of the pathological process, the sensitivity of microorganisms to the effects of the drug, liver and kidney functions, as well as the general condition of the patient. This confirms the instructions for use for the Zoflox preparation.
Methods of use: tablets are taken orally as a whole, washed down with water, preferably before or during meals. Adults, as a rule, are prescribed 200-800 mg, the multiplicity is 2 times a day, the course of treatment is 7-10 days. In the treatment of gonorrhea - once in a dose of 400 mg.
The solution is administered intravenously dropwise at an initial dose of 200 mg, the infusion duration is up to 60 minutes, only fresh solutions are allowed to be administered.
For infections of the urinary and genital organs, the drug is taken 100-200 mg 2 times a day.
The daily dosage for the prevention of infectious diseases with a decrease in immunity is 600 mg. After eliminating the symptoms of the disease and completely normalizing the temperature, treatment should be continued for another three days.
In childhood, the drug can be used only in case of a life threat, when the intended benefit is higher than the risk to the child's health.
Consider how to choose a dosage if kidney function is impaired. In this case, the amount of antibacterial drug should be reduced. That with creatinine clearance of 20-50 ml per min. the dosage should not exceed 100-200 mg per day, if this indicator is less than 20 ml per minute, then not more than 100 mg. Patients who are on hemodialysis or peritoneal dialysis should not take more than 100 mg per day.
Persons diagnosed with severe liver disease should not consume more than 400 mg.
Adverse reactions from the use of the drug
According to the instructions and reviews about Zoflox, this medication can cause the following negative reactions of the body:
- high urea, hypercreatininemia, interstitial nephritis, impaired renal function;
- increased intracranial pressure, phobias, blurred consciousness, headache, tremor of the extremities, dizziness, impaired coordination, psychomotor agitation, depression, convulsions, paresthesia of the extremities;
- pseudomembranous enterocolitis, cholestatic jaundice, gastralgia, anorexia, dyspepsia, diarrhea, flatulence, hyperbilirubinemia;
- myalgia, tendosynovitis, tendonitis, arthralgia, tendon rupture;
- tachycardia, vasculitis, collapse, low blood pressure;
- bullous hemorrhagic dermatitis, petechiae, papular rash, which indicates vascular damage;
- diplopia, impaired taste, balance, hearing, color perception and smell;
- hemolytic anemia, pancytopenia, agranulocytosis, leukopenia, anemia, thrombocytopenia;
- urticaria, fever, eosinophilia, allergic nephritis or pneumonitis, bronchospasm, Quincke's edema, anaphylactic shock, photosensitivity, exudative erythema multiforme;
- vaginitis, dysbiosis, hypoglycemia, thrombophlebitis.
The main symptoms of an overdose with this medication are lethargy, vomiting, confusion, drowsiness, dizziness, disorientation. In this case, symptomatic therapy is prescribed, including washing the stomach and intestines. Side effects can occur regardless of whether a dosage of 200 or 400 mg is prescribed. In the instructions for use with Zoflox, everything is described in sufficient detail.
Special instructions for the use of the medication
The drug is not the drug of choice for pneumonia caused by pneumococci. For the treatment of acute tonsillitis, it is also not indicated. It is undesirable to use the medication for more than two months. If during the treatment period there are side effects from the central nervous system, allergic symptoms and pseudomembranous colitis, Zoflox should be canceled.
In cases of colonoscopic or histological confirmation of pseudomembranous colitis, Metronidazole and Vancomycin (oral) are used. Tendonitis, which is rare, but occurs in some cases during treatment with this drug, can provoke tendon ruptures, most often in elderly patients.
Women are not recommended to use hygienic tampons during therapy, which is associated with an increased likelihood of developing vaginal candidiasis.
In some patients, an increased frequency of porphyria attacks and a complication of the course of myasthenia are noted.
Drug interaction
In accordance with the instructions to Zoflox, the drug in the form of an infusion solution is compatible with a solution of sodium chloride, dextrose and fructose, as well as with Ringer's solution. At the same time with heparin, it should not be used because of the risk of precipitation. When combined ofloxacin with cimetidine, furosemide, methotrexate and drugs that are responsible for blocking tubular secretion, its plasma concentration increases. Instructions for use with Zoflox (200 mg) confirm this.
The absorption of ofloxacin with the formation of insoluble complexes decreases with antacids. When used with glibenclamide, its concentration increases, with vitamin K antagonists, control of blood coagulation functions is required, with theophylline, its clearance decreases, with anti-inflammatory non-steroid drugs, as well as with nitroimidazole metabolites and methylxanthines, the likelihood of developing neurotoxic reactions increases, with glucocorticosteroids impaired tendon integrity, with urine alkalizing preparations, including citrates, carbonic anhydrase inhibitors, sodium bicarbonate - increases the likelihood of crystalluria and nephrotoxic effects.
This is stated in the instructions for use with Zoflox.
Analogues of a drug
Drugs similar in composition and therapeutic effect in this case are:
- Ashof;
- Ofloxacin;
- "Tarid";
- "Zanocin";
- Danzil
- Ofloxabol;
- "Tariferide";
- Ofloks;
- Roflo
- Oflo;
- Phloxal.
Analog drugs and price
Analogous products include: Oflobak, Ofloxacin-Promed, Tarivid, Ofloxin, Meneflox, Taritsin.
How much is the drug? We will examine in more detail in this matter.
Solution for injection can be purchased for 250 rubles. Zoflox tablets (200 mg) for 150 rubles. And in the blister there will be 5 pieces. 400 mg tablets for 200 rubles. (5 items). The cost of the drug largely depends on the region and the pharmacy network.
Reviews on this drug
The reviews about this medication contain a lot of information about the poor tolerance of this medicine, but its high effectiveness. Patients note that with the development of some dangerous infectious and inflammatory pathologies, the drug quickly helped them not only to get rid of the symptoms, but also to cure the disease itself. Nevertheless, they note that it is best used strictly according to the recommendation of a specialist, since the drug has high toxicity and causes a lot of serious side effects. These symptoms include stool disorders - in some patients, taking it has led to prolonged diarrhea, impaired heartbeat, and even cardiac arrhythmias, a change in psychological state - irritability, insomnia, anxiety, etc.
Based on expert reviews, we can conclude that this medication is advisable to use only in extreme cases, with the development of severe infectious pathologies and only for the intended purpose, since this medication is very dangerous with uncontrolled intake and can cause a wide variety of negative effects of an irreversible nature. Nevertheless, doctors note that the drug is highly effective, it is widely used in clinical medicine for the treatment of diseases indicated in the indications for the use of this medicine. In addition, they recommend that the dosage of the drug be carefully observed.
The article was presented instructions for use and reviews of "Zoflox."