The drug "Buserelin-Long" is an artificial analogue of the natural GnRH hormone. The basis of the action of this drug is competitive binding directly to the pituitary cell receptors and a subsequent short-term increase in the level of sex steroids in the plasma, which ultimately leads to the complete blocking of the so-called gonadotropic
function of the pituitary gland. As a result of the use of the Buserelin-Long preparation, hormone synthesis is directly suppressed in the gonads, which manifests itself in the form of a decrease in testosterone levels (to post-castration parameters) in men and a decrease in blood estradiol to post-menopausal characteristics in female patients. In the first case, we can talk about pharmacological castration, in the second - about postmenopause or ovariectomy.
This medicine is currently available in the form of a lyophilisate, specially designed for the preparation of a suspension. The composition of this drug as the main element includes about 4 mg of buserelin acetate. Auxiliary components are sodium carmellose, a copolymer of glycolic and dl-lactic acids, polysorbate-80 and d-mannitol.
As for the area of use of this medication, Buserelin-Long is prescribed for the treatment of breast cancer and hormone-dependent prostate cancer. In addition, this drug can be used during the treatment of endometriosis. For the treatment of uterine fibroids and infertility (as part of the IVF program), the use of Buserelin-Long should also be started . Reviews of doctors indicate good results of its use for the treatment of endometrial hyperplastic processes.
If we talk about the main contraindications to the appointment, then using this drug is strictly contraindicated for people with individual intolerance to buserelin acetate, as well as any of its other auxiliary components. In addition, lactation and pregnancy are contraindications.
Separately, it should be said about the possible side effects of using Buserelin-Long, since it can, for example, cause the appearance of urticaria, angioedema and hyperemia. In addition, conditions such as demineralization, sleep disturbance, headache, and depression can be observed.
Female patients have lower abdominal pain, a change in libido, excessive sweating,
menstrual bleeding and dryness of the vaginal mucosa due to the use of the synthetic drug Buserelin Long. Side effects in men are mainly associated with an exacerbation of the underlying disease, urinary retention, gynecomastia, and "renal edema." In addition, there may be a decrease in potency, increased sweating, muscle weakness in the limbs, and bone pain. In a small number of patients, reactions such as
dyspeptic disorders and pulmonary thromboembolism may occur.