The article discusses the instructions for use and reviews for the Platifillin medication.
The drug is included in the group of blockers of M-cholinergic receptors. The drug has a predominantly antispasmodic and very mild sedative effect. Doctors often prescribe medication for patients who have certain problems with intestinal function. Among the indications, specific diseases of the cardiac and vascular systems, lung diseases were also noted. Instructions for the use of "Platifillin" in injections are very detailed.
Release form
"Platifillin" is made in transparent glass ampoules, inside which the solution is administered parenterally. Each bottle with a volume of one millimeter and its concentration is 0.2%.
Ampoules during production are packed in cardboard honeycomb boxes of ten units each. The pack also has an instruction, a knife, with which an ampoule is opened, that is, a scarifier. There may also be ampoules with openings or dots, in which case the knife is not included.
Structure
Among the constituents, only two milligrams of platifillin hydrotartrate are indicated by the manufacturer. Instructions for use indicate that there is also water for injection in each ampoule. The liquid externally has no color, a specific aroma, a uniform consistency.
Indications
According to the instructions for use, "Platifillin" is prescribed to patients when they diagnose a number of conditions or diseases:
- cholelithiasis and cholecystitis;
- colic in the stomach, intestines, liver and pylorospasm;
- duodenal or stomach ulcers;
- angiotrophoneurosis;
- algodismenorea.
As an integral part of complex treatment, with angina pectoris or arterial hypertension, bronchorrhea, cerebral artery spasms. As a prophylactic for laryngo- and bronchospasm, if the patient has bronchial asthma.
In addition, the instructions contain information that this drug can be prescribed to patients in the treatment of a number of ophthalmic diseases. The list of such conditions includes traumatic damage to the organs of vision and acute stages of the inflammatory process. In addition, in ophthalmology, “Platifillin” can be prescribed before diagnostic procedures, when it is necessary to expand the pupils of the patient.
Contraindications
As the instructions for use for "Platifillin" indicate, there is an extensive list of contraindications that you must familiarize yourself with before treatment with the drug. Given this fact, it is not recommended to drink the drug on its own, without first consulting with a specialist.
In accordance with the instructions for use, injections of "Platifillin" are not given intramuscularly.
Intravenous injections are strictly prohibited in the following cases:
- an increased degree of sensitivity to the main active component of the drug and the possibility of allergic reactions;
- severe form of atherosclerosis;
- angle-closure glaucoma;
- heart failure of a chronic form of the second and third degree;
- disturbed or unstable heart rhythm, tachycardia;
- symptoms of liver or kidney failure;
- benign prostatic hyperplasia;
- diaphragm hernia with signs of reflux esophagitis;
- elderly age;
- intestinal atony;
- ulcerative colitis;
- bleeding from the intestines or stomach.
The drug is prescribed with extreme caution to patients when carrying a baby and breastfeeding. Such patients should be carefully monitored, in the history of which there are: mitral stenosis, thyrotoxicosis, coronary heart disease, arterial hypertension, diseases of the digestive system with obstruction, high temperature.
It is necessary to monitor the treatment process in patients after forty years, since there is a risk of uncertain glaucoma. Very carefully, the medicine is prescribed for patients with diagnosed ulcerative colitis, with urine retention, with myasthenia gravis, chronic pulmonary diseases, cerebral palsy, and with Down's disease.
Instructions for use with "Platyphylline" must be strictly observed.
Required dosage
The drug is administered both subcutaneously and intravenously. Compared to other forms of the drug, the onset of the injection is much faster.
With the introduction of the medication by the subcutaneous method, the patient can eliminate spastic pain that occurs with a prolonged attack of bronchial asthma, as well as with peripheral and cerebral angiospasm. It is advisable to use 1-2 milliliters of the drug with a concentration equal to 0.2%. The procedure is done 1-2 times throughout the day.
With the task, to eliminate acute pain that develops with renal, intestinal or hepatic colic, duodenal ulcer and stomach in the acute stage, the drug is administered to patients subcutaneously in the same concentration. Such a frequency of manipulations as three times a day is recommended. The amount of funds administered is from one to two milliliters.
What else can you learn from the instructions for use with Platifillin?
To reduce blood pressure and dilate blood vessels, this drug is best administered intravenously.
Regarding the use of the drug in pediatrics, it must be said that the instructions contain information with the necessary norms. For newborns and infants, the dose is determined taking into account body weight according to this formula: for each kilogram, 0.0175 ml. For children from one to five years, the volume of the drug is 0.015 ml, respectively. From the age of six to the age of ten, children are already given 0.0125 ml per kilogram. 11-14 years old - dosage of 0.01 ml also per kilogram of body weight.
Interaction
According to the instructions for use, "Platifillin" in ampoules interacts with other drugs as follows:
- analgesics - increases the effect of "Platifillin" to eliminate pain;
- “Haloperidol” - the antipsychotic effect in schizophrenic patients may decrease;
- Cardiac glycosides - a positive bathmotropic effect ;
- "Proserin" - "Platifillin" in this case acts as an antagonist;
- "Morphine" - the inhibitory effect of "Platifillin" on the vascular and cardiac system is increased;
- “Phenobarbital” - the duration of sleeping pills is increasing.
All this information should be considered in combination treatment.
Reviews about the injections "Platifillin" in the instructions for use are not indicated. We will consider them below.
Side effects
Patients and doctors among the negative manifestations noted the occurrence of the following conditions:
- intestinal atony;
- constant thirst and dry mouth;
- lowering blood pressure;
- dilated pupils, dizziness, pain, accommodation, paralysis;
- tachycardia;
- convulsions, acute psychosis, photophobia, excitement of the central nervous system;
- pulmonary atelectasis;
- urination disorders and urine retention.
The likelihood of the onset of the above negative manifestations becomes higher with increasing minimum dosage, which is required to achieve a therapeutic effect. Special studies regarding the determination of negative symptoms during treatment of pregnant women and during lactation have not been conducted.
Given the fact that this drug acts on the central nervous system, patients need to refrain from activities with complex mechanisms throughout the period, to avoid processes that require a high degree of concentration for a long time, and not to drive a car on their own. And it is important to remember that injections are not administered intramuscularly.
Instructions for use with "Platifillin" does not end there.
Overdose
If an overdose of the drug has occurred, the side effects described above are amplified in patients. For therapeutic purposes, in order to eliminate the symptoms of overdose, patients are advised to perform forced diuresis and prescribe the administration of cholistenase inhibitors, which are represented by Proserin, Galantamine, and Physostigmine. These medications cause a weakening of intestinal paresis and reduce tachycardia.
With a moderate degree of excitation of the nervous system or moderate to mild seizures, patients are injected with magnesium sulfate. However, in cases where an overdose of the drug is classified as severe, sodium oxybutyrate is prescribed, oxygen therapy is performed, the person is connected to an artificial lung ventilation device. If there is a threat to the patient's life, with tachycardia, "Propranolol" or quinidine sulfate should be taken.
Reviews
The drug "Platifillin" is truly highly effective, which is noticeably confirmed by reviews on medical forums about its use.
The reviews also confirm the effectiveness of the drug, but the process requires very great care, since Platifillin is able to affect smooth muscle, a person cannot control its relaxation and tension - he only feels the consequences of increasing tone or atony.
Timely stopping by a qualified specialist who is able to correctly regulate medical interventions in such an area without causing significant harm to health is necessary.