Bismuth tripotassium dicitrate (trade name - the drug "De-Nol") is an effective anti-ulcer drug with pronounced bactericidal activity against microorganisms of the Helicobacter pylori species. In addition, this medicine has antacid, anti-inflammatory and astringent effects. Taking this remedy significantly improves the protective characteristics of the gastrointestinal mucosa, forming a special insoluble coating directly at the site of the ulcer. Also, bismuth tripotassium dicitrate increases the resistance of the membrane of the stomach and intestines to the negative effects of enzymes, pepsin and hydrochloric acid, increases mucus production, secretion of bicarbonates and the synthesis of type E prostaglandin. In addition to all of the above, experts note its ability to stimulate the activity of cytoprotective mechanisms.
As for the pharmacokinetics of this anti-ulcer agent, as a result of its course application, equilibrium blood concentrations are reached after four to five days, and the half-life is about five days. In this case, the fully active component is excreted from the body only twelve weeks after the start of taking such an agent as bismuth tripotassium dicitrate. Analogues of this tool - capsules "Bismay", "Desmol" and "Novobismol" - have a similar mechanism of action.
This anti-ulcer drug is produced mainly in the form of conventional coated coated tablets. Take De-Nol tablets (bismuth tripotassium dicitrate), the price of which is very affordable, the manufacturer recommends exclusively for the treatment of duodenal ulcers or stomach ulcers. People suffering from chronic gastritis should also start taking this medication regularly. In addition, bismuth tripotassium dicitrate will quickly help in case of dyspepsia, not associated with organic diseases of the gastrointestinal tract.
Doctors categorically prohibit taking this antiulcer drug in severe forms of impaired renal function, as well as during pregnancy. Hypersensitivity and the period of breastfeeding of a newborn baby are likewise included in the list of strict contraindications. Patients who have not reached the age of twelve should also not start taking medications that include bismuth tripotassium dicitrate. In addition, it is always necessary to remember that in people with various kinds of abnormalities in the work of the kidneys as a result of prolonged use of high dosages of this drug, encephalopathy may develop.
If we consider the most common adverse reactions, the appearance of which can be caused by taking this antiulcer drug, then vomiting, nausea and diarrhea should be highlighted first. In addition, there is a fairly high risk of skin rash, itching, redness of the skin and angioedema.