Anaprilin is a cardiological drug used to eliminate arrhythmias and high blood pressure. The therapeutic effect develops over time, so the patient should take the medicine regularly and for a long time.
Structure
According to the instructions for use, Anaprilin is a medication belonging to the group of beta-blockers. The active component in its composition is propranolol, which can reduce the frequency and power of heart contractions. As additional substances are used: colloidal silicon dioxide, hypromellose, microcrystalline cellulose, talc, calcium stearate, milk sugar, starch.
Is Anaprilin permitted during pregnancy? About it below.
Pharmacological forms
The manufacturer produces the drug in two pharmacological forms - tablet. Tablets may have a dosage of 10, 40 mg. Packed in contour plastic packaging with cells, or in containers made of plastic or glass. Each package may contain 10, 50, 100 mg.
Indications for use of the drug
In accordance with the instructions for use with Anaprilin, the main indications for the use of the drug are pathological disorders in the CVS, which are accompanied by high blood pressure. The drug can be prescribed for the treatment of atrial or sinus tachycardia, mitral valve prolapse, myocardial infarction.
The medication for arrhythmia is quite effective, it is also able to relieve the symptoms of an oncoming migraine. Initially, the drug was created only for adult patients, but now it is also used in the treatment of children, if there are indications.
The main indications of Anaprilin are pathological conditions such as:
- Pheochromocytoma.
- Coronary heart disease.
- Cardiomyopathy
- Tachycardia.
- Angina pectoris, characterized by instability.
- Arterial hypertension.
- Frequent discomfort and pain in the heart.
Pharmacological effects of the drug
In accordance with the instructions for use with "Anaprilin", the active component in the composition is capable of exerting a hypotensive, antiarrhythmic, antianginal effect. Regular use of the drug leads to a decrease in the intensity of heart contractions, a decrease in the oxygen demand of the heart muscle.
Under the influence of "Anaprilin" arterial pressure normalizes, peripheral resistance of various vessels improves. In addition, against the background of the action of propranolol, uterine muscular contractions increase, bleeding stops after operations and childbirth, digestive function is stimulated, and calcium ions enter the cells.
The antihypertensive effect normalizes on average 2 weeks after the start of the drug. Antianginal effect is realized by reducing the need for myocardial oxygen (due to the occurrence of a negative chronotropic effect). The use of "Anaprilin" leads to a decrease in the severity of ischemia, a decrease in the likelihood of death as a result of antiarrhythmic effects.
Propranolol is able to prevent migraines by reducing the expansion of arterial lumens. When using the drug, tremor is reduced.
When using the drug in high doses, its sedative effect is manifested. How long does Anaprilin work?
The active substance enters the bloodstream rapidly, half the entire dose is excreted in an average of 5 hours, if the drug is used for a long time, the half-life is increased to 11 hours. Propranolol metabolites are evacuated via the kidneys. Positive dynamics in patients can be observed after a month of using the medication.
The use of a drug
As indicated by the instructions for use, Anaprilin should be used solely on the recommendation of a doctor, in no case should it be used as part of self-medication. It is recommended to take tablets before meals, in about half an hour, drinking plenty of water. Do not break or chew tablets. The effect develops a couple of hours after application, lasts about 5 hours.
To accelerate the onset of the effect, sublingual use of tablets is allowed, however, it must be borne in mind that this method of application can cause numbness of the tongue.
The frequency of applications per day, as a dosage and a long therapeutic course, is determined by a specialist taking into account the type of disease, its course, age of the patient. As a rule, the therapy of vascular and cardiac pathologies takes up to 4 weeks. If necessary, the doctor may recommend resuming the course.
For the purpose of therapy of arrhythmic manifestations, it is indicated to take up to 30 mg of propranolol three or four times a day.
Therapy of arterial hypertension should begin with a minimum dosage of 80 mg, the drug should be taken twice a day. Then, depending on the condition of the patient, the dosage may be doubled.
For the purpose of migraine therapy, Anaprilin must be taken in an amount up to 160 mg per day.
If angina is treated, the patient is recommended to take 20 mg of propranolol four times a day in the first three days, and in the next three days, the dosage should be doubled, and the frequency of doses reduced to three. On the seventh day of therapy, one should return to the initial dosage. If necessary, the frequency of doses can be increased to 6, and the dosage to 40 mg.
Against the background of a heart attack, 40 mg of propranolol is shown four times a day.
For the treatment of essential tremors, it is shown to use the initial dosage, which is 20 mg, and the frequency of doses is up to 4 times a day. Over time, the dosage must be doubled.
"Anaprilin" can be used in the treatment of children, however, therapy can be carried out from 3 years old, only as prescribed by the doctor, and exclusively in small doses. The calculation is based on 0.25-0.5 mg / kg. Application should carry out up to 4 times a day. Extreme caution should be exercised when using the medicine in children, and therapy using Anaprilin should be carried out under stationary conditions and under the supervision of a doctor.
"Anaprilin" with tachycardia is very effective. The drug can be used in panic attacks, effectively lowering the frequency of compression of the heart, normalizing blood pressure, which during a panic attack, as a rule, decreases, relieving baseless fears, reducing anxiety attacks in a short time.
What is the compatibility of Anaprilin? It can be successfully combined with cardiac glycosides. Drug withdrawal should be carried out gradually, otherwise myocardial ischemia is not ruled out.
Indications "Anaprilina" we reviewed. Next, let's talk about contraindications.
Contraindications to the use of this drug
The medication should not be used if there are the following contraindications:
- Bradycardia
- Hay fever.
- Arterial blood flow disorders.
- Severe myocardial infarction.
- Diabetes.
- Colitis.
- With blocking of the atrioventricular type, which is accompanied by insufficiency, activity of the left or right ventricle.
The use of Anaprilin during pregnancy is unacceptable, since clinical practice currently does not have enough information confirming the safety of propranolol when used in this period. A contraindication to the use of the drug is the lactation period, since the components are able to penetrate into breast milk.
You should not use the drug for bronchial asthma, in parallel with tranquilizers.
It is strictly forbidden to use drinks containing alcohol as part of Anaprilin therapy, since ethanol and propranolol are incompatible substances. Such a combination can provoke complications up to death, and the therapeutic effectiveness of the drug is minimized. With the parallel intake of alcohol and propranolol, the patient immediately develops the following negative symptoms: vomiting and nausea, chills, low blood pressure, fainting.
It should be noted that therapy with Anaprilin containing propranolol can provoke exacerbation and intensification of psoriasis. This must be taken into account for patients suffering from this pathology.
Analogs of Anaprilin should be selected by a doctor.
Negative impact
Against the background of the use of the drug, the following negative reactions may develop:
- Insomnia.
- Leukopenia
- Respiratory failure.
- Alopecia.
- The inflammatory process in the large intestine.
- Visual impairment.
- Decreased libido, potency.
- Heart failure.
- Bradycardia
- Depressed state.
- Depression.
- Muscle weakness.
- Cramps in the stomach.
- Vomiting, nausea.
- Itchy skin.
- Diarrhea.
- Pharyngitis.
- Dyspnoea.
- Coughing.
If negative effects occur, you must inform your doctor about them.
Overdose
In case of an overdose of Anaprilin, the patient develops the following symptoms:
- Acrocyanosis.
- Arrhythmia.
- Bronchospasm.
- Respiratory failure.
- Dizziness.
- Cramps.
- Headache.
Very often, an overdose develops when the patient takes the medication for panic attacks and without a doctor's prescription. This is due to the patient's inability to independently choose a safe dosage.
With the development of overdose symptoms, the patient should undergo gastric lavage and begin symptomatic treatment.
Cost
The average cost of Anaprilin packaging in Russian drugstores is 20 rubles. The price depends on the number of tablets in the package, their dosage, the region of distribution and the pricing policy of the pharmacy chain.
Analogs of Anaprilin
If necessary, Anaprilin can be replaced with one of the following drugs: Inderal, Lokren, Niolol, Ganfort, Xonef, Phenazel, Noloten, Obzidan, Propamine, Stobetin.
However, it must be borne in mind that each of these medicines has a number of its own contraindications and negative effects, so any replacement of the drug should be agreed with the doctor. This will make the therapy as effective as possible and avoid complications.
Reviews
“Anaprilin”, judging by the feedback from users, is not only inexpensive, but also an effective medicine. The drug is often used for VSD, it allows to lower blood pressure, stabilize the activity of the heart, and normalize the heart rhythm.
A negative characteristic of the drug is that it is only a means of symptomatic therapy and is not able to stop the cause of the pathology. Often there are messages indicating the ability of Anaprilin to provoke the development of negative manifestations.
It is important to remember that therapy with this drug should be prescribed by a specialist.