Longidase suppository is a long-acting drug with enzymatic proteolytic activity (like the natural enzyme hyaluronidase), as well as immunomodulating, antioxidant and anti-inflammatory effects. The long-term effect of longidase is due to the fact that when it enters the body, it binds to a high molecular weight carrier that prevents its destruction. Longidase prevents the acute course of the inflammatory process from developing by regulating the production of substances that provoke inflammatory reactions (tumor necrosis factor, interleukin-1). Compared with hyaluronidase (an enzyme produced in the body), longidase is more stable. In contrast to the natural enzyme, longidase not only destroys the connective tissue, which grows rapidly during inflammation, but also adsorbs substances that activate the inflammatory process (copper, iron, heparin ions).
The effect of longidase is manifested in flattening of scars, reducing swelling of the tissue, increasing joint mobility, preventing the formation and reduction of already formed contractures, and suppressing the adhesion process. The drug "Longidase suppository" does not affect normal connective tissue, but destroys only altered connective tissue in the area of fibrosis. The drug is well tolerated, rarely causes side effects with increased individual sensitivity. It does not have mutagenic, teratogenic, embryotoxic and carcinogenic effects.
The use of "Longidase suppository" does not cause deterioration of the patient after surgery, does not interfere with the restoration of bone tissue, does not exacerbate infectious diseases. The use of longidase in the complex treatment of diseases accompanied by active proliferation of connective tissue (the main cause of which are inflammatory processes) is shown. In urology, such situations can occur with interstitial cystitis, chronic prostatitis, strictures of the urethra and ureters, Peyronie's disease, after operations on the ureters, bladder or urethra. In gynecology - with adhesions that occur during inflammation after operations on the pelvic organs, gynecological manipulations, with chronic endomyometritis, intrauterine synechia. In dermatovenerology - with limited scleroderma, the prevention of complicated fibrotic infections. In surgery - for the prevention and treatment of adhesions after operations on the organs of the abdominal cavity, for the treatment of nonhealing wounds for a long time. Contraindications to the use of longidase are malignant neoplasms, pregnancy, and hypersensitivity to the drug. With caution, the drug should be used for kidney diseases, especially renal failure, in the presence of a history of pulmonary hemorrhage .
Side effects are rarely detected. More often it is an allergic reaction. With increased sensitivity to the drug, "Longidase suppository" is used, 1 suppository after 1-3 days, depending on the disease. Course - 10 suppositories. If necessary, additional supportive therapy is prescribed. A second course is possible in three months. Maintenance therapy can take up to several months (up to four). If allergic reactions occur, discontinue treatment with the drug immediately. In the presence of a concomitant infectious disease, it is necessary to combine longidase with antimicrobial agents prescribed by a doctor. The drug is dispensed without a doctor’s prescription.
The drug "Longidase suppository", there is an analogue - this is Polyoxidonium.
If you yourself, without a doctor’s prescription, purchase Longidaza suppositories, you should carefully study the instructions for their use in order to avoid undesirable consequences.