Ranisan is a drug that can reduce the secretion of the gastric glands. The drug helps many patients from heartburn and stomach pain. Reviews about the medication are only positive. The article will describe “Ranisan” and instructions for applying to it.
General information
The manufacturer produces the medication in tablets that have a film membrane, a round and convex shape on both sides, light pink or almost white. The dosage of tablets can be 75 and 150 mg. They are packaged in blisters of 10 pieces. Additionally, blisters are placed in cardboard packs. Each pack of tablets with a dosage of 75 mg contains one blister, with a dosage of 150 mg - 1 or 2 blisters.
According to the instructions for use, Ranisan includes ranitidine hydrochloride. This is the main active substance. Auxiliary components are:
- microcrystalline cellulose;
- corn starch;
- magnesium stearate;
- copovidone;
- povidone 25.
The composition of the film membrane contains:
- hypromellose 15;
- hypromellose 5;
- titanium dioxide;
- magnesium stearate;
- dye red iron oxide;
- dye yellow iron oxide;
- emulsion of simethicone.
Pharmacokinetics, pharmacodynamics
The active ingredient in Ranisan is ranitidine, a second-generation H2-histamine receptor blocker. The mechanism of its effect is determined by the ability to block H2-histamine receptors located in the membranes of parietal cells of the gastric mucous membranes.
Under the influence of the drug, basal and stimulated secretion of gastric juice is inhibited. The tool helps to reduce the volume of hydrochloric acid, which increases under the influence of biogenic stimulants (caffeine, pentagastrin, gastrin, histamine, acetylcholine), hormones, due to food stretching of the stomach.
Hepatic enzymes in the process of reducing the volume of hydrochloric acid are not suppressed.
Effect on pepsin activity
In addition, under the influence of "Ranisan" pepsin activity decreases. It does not affect the process of mucus secretion, the concentration of gastrin in the plasma, the level of prolactin, the content of calcium ions does not reduce. The concentration of aldosterone, androgens, estrogens also does not affect the synthesis of pituitary hormones (thyrotropic, somatotropic, gonadotropic hormones).
The agent is absorbed in the digestive tract quickly enough. Pharmacokinetic properties, plasma concentration, absorption rate do not depend on the simultaneous intake of food.
In accordance with the instructions for use with Ranisan, the maximum concentration in the blood is noted 2-3 hours after using the product, the availability of the substance is about 50%, the connection with blood plasma proteins is 15%.
The half-elimination period is 2.5 hours, in patients with reduced creatinine clearance it can increase to 9 hours.
What else does the application instruction for Ranisan tell us?
Indications for use
The medication is prescribed for the symptomatic treatment of dyspeptic disorders, which are associated with an increase in the acidity of gastric juice, for example, nausea, heartburn, acid burping.
Contraindications in the instructions for use of "Ranisan" are also described.
Who should not take it
The drug is absolutely contraindicated for use if the patient has such physiological or pathological conditions:
- Increased susceptibility to substances in the composition of the drug.
- The lactation period.
- Age up to 3 years.
- The presence of malignant ulcerative lesions of the stomach.
It is important to exercise caution when using the product in the following cases:
- Pregnancy.
- Acute forms of porphyria, as well as the presence of information about such a history.
- Renal failure.
- Liver failure.
- The presence of a history of information about liver cirrhosis, accompanied by portosystemic encephalopathy.
- Oppression of immunity.
- Age 3-12 years.
Drug use
As indicated by the instructions for the use of "Ranisan", it should be taken orally. It is necessary to swallow the tablet whole, avoiding crushing and grinding. It is recommended to drink plenty of water with plenty of water.
As a rule, a medicine is taken if such a need arose - heartburn or other dyspeptic symptoms appeared. Take one tablet. During the day, no more than two pills are allowed.
In the absence of other doctor's recommendations, therapy should be continued for two weeks.
Negative impact
Instructions for use with "Ranisan" confirms that, against the background of use, the patient may develop the following side symptoms:
- Exfoliative dermatitis, toxic type epidermal necrolysis, exudative erythema multiforme, bronchospasm, angioedema, anaphylactic shock, urticaria, skin rash, itching.
- Mixed, hepatocellular or cholestatic hepatitis, acute pancreatitis, jaundice, increased activity of liver transaminases, vomiting, nausea, abdominal pain, dry mouth, constipation, diarrhea.
- Hyperprolactinemia, decreased libido, potency, gynecomastia, amenorrhea.
- Vasculitis, atrioventricular block, decreased blood pressure, arrhythmia, bradycardia, tachycardia.
- Hallucinations, irritability, confusion, tinnitus, depression, hyperthermia, dizziness, anxiety, anxiety, nervousness, insomnia, drowsiness, emotional lability, headache, increased fatigue, involuntary movements.
- Neutropenia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, hemolytic immune, aplastic anemia, aplasia, hypoplasia.
- Myalgia, arthralgia.
- Blurred vision, paresis of accommodation.
- Alopecia, hypercreatinemia.
With the development of this negative symptomatology, you should refuse to use the medication and seek the advice of a doctor.
Overdose
The instructions for use with Ranisan tablets indicate that the use of excessive doses can lead to intoxication, which is manifested by the occurrence of seizures, bradycardia, ventricular arrhythmia.
In case of intoxication due to an overdose, it is recommended to provoke vomiting. Therapy of intoxication is symptomatic. Effectively hemodialysis. In order to eliminate ventricular arrhythmias, the use of Lidocaine preparations is indicated, and for the purpose of stopping bradycardia, Atropina. In case of seizures, the patient is shown the intravenous administration of Diazepam.
Special instructions for use
According to the instructions for use with Ranisan, if the patient has a history of cases of unmotivated weight loss, the development of porphyria, cardiac arrhythmias, functional disorders of the heart, kidneys, stomach ulcers, he should consult a doctor before use. The same applies to cases of simultaneous use with other medicines.
Before starting therapy, it is recommended to be examined to exclude the presence of malignant pathologies of the duodenum, stomach, and esophagus.
For the period of therapy "Ranisan" should abandon the use of drugs, food, drinks, which can provoke irritation of the mucous lining of the stomach.
Long-term use of the drug by patients with poor health and in stressful situations can cause the development of bacterial lesions of the stomach and the subsequent spread of infection.
The use of ranitidine can cause false positive reactions when tested for the presence of protein in the urine.
Against the background of the use of Ranisan, the level of creatinine, gamma-glutamyl transferase, and glutamyl transpeptidase in the blood serum increases.
Ranitidine preparations interfere with the effects of pentagastrin and histamine on the acid-forming functions of the stomach, therefore it is not recommended to take the medicine during the day before the test.
Means that are H2 histamine receptor blockers can significantly reduce the absorption of Itraconazole and Ketoconazole. If there is a need for parallel therapy with these drugs, a minimum of two hours between their use should be maintained.
Ranitidine has the ability to suppress skin reactions to histamine, which is the reason for false positive results. You should stop using the medication if you have to undergo diagnostic skin tests in order to identify immediate allergic reactions.
The effectiveness of “Ranisan” (a decrease in the nighttime secretion of gastric juice) may decrease due to smoking.
It is not recommended to abruptly refuse to use ranitidine, since there is a likelihood of withdrawal syndrome.
Patients whose activity is associated with the management of complex mechanisms, vehicles and requires the speed of psychomotor reactions should be careful during medication.
This is confirmed by the instructions for use. Photo "Ranisana" presented in the article.
Use in the lactation period, during pregnancy
It is allowed to use the drug during pregnancy, however, therapy should be carried out with caution and under the supervision of a specialist.
Ranitidine is able to pass into breast milk. The concentration of the active component in it is much higher than in the blood. Therefore, the lactation period is a contraindication for the use of Ranisan.
Interaction with other medicines
In accordance with the instructions for use with "Ranisan" in tablets, parallel use with "procainamide" leads to an increase in its concentration in the blood plasma.
When used together with "Theophylline" there is an increase in its concentration in the blood plasma. As a result, a feeling of depression may arise, tachycardia may develop.
Joint use with "Ketoconazole" and "Itraconazole" leads to a decrease in their absorption.
When used with agents that can inhibit bone marrow activity, the likelihood of neutropenia increases.
Ranitidine preparations are able to inhibit the hepatic metabolism of the following drugs: Phenytoin, Propranolol, Metoprolol, Warfarin, Metronidazole, Theophylline, Aminophenazole, Hexobarbital, Nifedipine, Glipizide Aminophylline "," Buformin "," Phenazole "," Diazepam "," Lidocaine ", indirect anticoagulants.
In the instructions for use, analogues of "Ranisan" are not indicated. Consider them below.
Analogs
If necessary, Ranisan can be replaced with one of its analogues. The most popular are: “Famotidine”, “Ranitidine”, “Kvamatel”, “Zantak”, “Histak”, “Atzilok”.
It should be remembered that all of these drugs have their own list of contraindications and can cause the development of side symptoms, so the possibility of replacing the medicine should be discussed with your doctor.
Patients' Opinions About Ranisan
According to reviews, Ranisan is an effective means of eliminating various dyspeptic manifestations if they are associated with high acidity in the stomach. The medicine is fairly well tolerated, negative symptoms rarely develop. Most often, patients use Ranisan if heartburn occurs.
An important advantage of the tool is its democratic value. In Moscow, a package of 20 tablets can be bought for only 50 rubles.
Many patients write that the medication eliminates pain in the stomach in just a few minutes. Therefore, many people have this drug in their home medicine cabinet. We reviewed the instructions for use and reviews of "Ranisan".