Cheap analogues of "Vesicar": list of drugs, instructions for use

"Vesikar" is a medication that helps reduce the tone of the smooth muscles of the urinary tract. The drug belongs to the group of antispasmodics. Used for the treatment of urological diseases.

"Vesikar" is produced in tablet form, in dosages of 5 and 10 milligrams. The main component is solifenacin succinate.

Additional substances are:

• lactose monohydrate;
• corn starch;
• hypromellose;
• magnesium stearate;
• macrogol;
• hypromellose;
• talc;
• titanium dioxide;
• dyes.

What analogues of medicine "Vesikar" exist?

pharmachologic effect

The active substance has an intense antispasmodic effect. A component of a specific competitive inhibitor of muscarinic cholinergic receptors.

The pharmacological effect of the drug is observed already in the first week of therapy, normalizes in the next twelve weeks of using "Vesicar". The maximum therapeutic effect is achieved on average after 4 weeks of treatment. The effectiveness of therapy lasts up to a year.

The maximum content of solifenacin in the blood is reached after 3–8 hours after taking the tablets. In this case, the maximum content increases in proportion to the increase in dosage from 5 to 40 milligrams. The absolute bioavailability of solifenacin is ninety percent.

Indications

"Vesikar" is used in the symptomatic treatment of people with overactive bladder syndrome, which is accompanied by:

1. Urinary urinary incontinence.
2. Imperative urination.
3. Frequent urination.

Limitations

Prohibitions on the use of medicines are:

1. Urinary retention.
2. Severe kidney disease.
3. Angle-closure glaucoma (a pathological process that leads to injury to the optic nerve).
4. Severe digestive diseases.
5. Myasthenia gravis (an autoimmune neuromuscular disease characterized by pathologically rapid fatigability of striated muscles).
6. Severe liver disease.
7. The implementation of hemodialysis.
8. Hereditary galactose intolerance (a hereditary disease in which congenital insufficiency of enzymes that convert galactose into glucose is observed).
9. Lactase deficiency (violation of lactose cleavage due to insufficiency of the lactase enzyme of the small intestine mucosa, accompanied by clinical symptoms).
10. Glucose-galactose malabsorption (a rare metabolic disease in which the cells lining the intestine are not able to absorb two specific sugars, such as glucose and galactose).
11. Individual intolerance.
12. Childhood.

How to take medication

According to the instructions for use with Vesicar, the recommended concentration of the drug for adults (from 18 years old) and elderly patients is 5 milligrams per day. If necessary, the concentration of active substances increases to 10 mg per day. Tablets are taken orally, whole, daily, regardless of food intake. Washed down with water.

Adverse reactions

When using "Vesicar" in rare situations, negative effects may occur:

1. Mild headache.
2. Moderate dizziness.
3. Mild dry mouth.
4. Drowsiness.
5. Delirium (a disorder of thinking with painful arguments inherent in a given state, perceptions, conclusions that do not correspond to reality).
6. Confusion.
7. Hallucinations (an image that occurs in the mind without an external stimulus).
8. Violation of accommodation (the problem of adapting an organ or an organism as a whole to a change in external conditions).
9. Dry mucous membranes of the eyes.
10. Glaucoma (a large group of eye diseases characterized by a constant or periodic increase in intraocular pressure (IOP) with the subsequent development of typical visual field defects, decreased vision and atrophy of the optic nerve).
11. Nausea.
12. Heartburn.
13. Flatulence (a pathological condition of the body that occurs due to excessive gas formation and accumulation of gases in the gastrointestinal tract).
14. Pain in the abdomen.
15. Constipation.
16. Gastroesophageal reflux disease (a chronic relapsing disease caused by spontaneous, regularly repeated reflux of gastric and / or duodenal contents into the esophagus, leading to damage to the lower esophagus).
17. Intestinal obstruction.
18. Coprostasis (fecal congestion, which causes blockage of the lumen of the large intestine).
19. Loss of appetite.
20. Vomiting.
21. Violation of the liver.
22. Change in laboratory parameters of liver tests.
23. Difficulty urinating.
24. Infectious urinary tract inflammation.
25. Cystitis (inflammation of the bladder, a widespread urological disease of the urinary system).
26. Acute urinary retention.
27. Renal failure.
28. Dry nasal mucosa.
29. Swelling of the legs.
30. Fatigue.
31. Dry skin.
32. Itching and rash.
33. Urticaria (skin disease, dermatitis of predominantly allergic origin, characterized by the rapid onset of severely itchy blisters).
34. Erythema multiforme (acute immune-mediated inflammatory reaction of the skin and, in some cases, mucous membranes to various stimuli, characterized by target-like lesions with peripheral localization, prone to recurrence and self-resolution).
35. Exfoliative dermatitis (a whole group of diseases manifested by extensive lesions of the skin in the form of redness, thickening, thickening and strengthening of their pattern).
36. Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
37. Mydriasis (the state of the pupil, in which this element increases in diameter and ceases to respond to light).
38. Acute urinary retention.

Recommendations for use

From the instructions for use with "Vesicar" it is known that with extreme caution, the drug is prescribed for patients with certain concomitant diseases, including:

1. Obstruction of the outlet of the bladder (a pathological condition in which there is a violation of the outflow of urine).
2. Obstructive diseases of the digestive tract (including stagnation of food in the stomach).
3. Slow motility of the digestive tract.
4. Hernia of the esophagus.
5. Gastroesophageal reflux (reflux of gastric (gastrointestinal) contents into the lumen of the esophagus).
6. Autonomic neuropathy (disorders of the nervous system associated with a lesion in diabetes of small blood vessels).
7. Hypokalemia (a human condition characterized by a low potassium content in the blood).

During therapy with "Vesicar" it is necessary to pay attention to the following nuances:

1. Before treatment, you need to make sure that there are no other reasons that provoke involuntary urination.
2. If urinary tract infections are detected, antibiotic therapy is required.
3. There is no need for dosage adjustments for patients of retirement age.
4. Up to 18 years of age, the drug is contraindicated.
5. After therapy with "Vesicar" it is necessary to take a week break before using drugs of the M-anticholinergic group.
6. The medicine can provoke a visual impairment to clearly distinguish between objects, fatigue, so care should be taken during therapy to people whose activities require increased attention.

Drug interaction

When combined with M-cholinomimetics, the pharmacological effect of solifenacin is reduced.

With the simultaneous use of "Vesicar" with M-anticholinergic drugs, the therapeutic effect and adverse reactions of solifenacin increase.

When interacting with solifenacin, "Vesikar" reduces the pharmacological effect of medications that activate the motility of the digestive system.

"Ketoconazole", "Itraconazole", "Ritonavir" increase the bioavailability of solifenacin, therefore, when combined with these medicines, the maximum dosage of "Vesicar" should not exceed 5 mg. And people with kidney and liver diseases are not recommended to take these medicines.

You can not combine Vezikar with Verapamil, Diltiazem, Rifampicin, Carbamazepine, Phenytoin.

Pregnancy and breastfeeding

Clinical information about the safety and effectiveness of the use of "Vesicar" in women is not available, therefore it is necessary to use the drug with extreme caution during an "interesting situation.

There is no information on the release of solifenacin into breast milk. The medication should not be used during lactation. What analogues and cost does Vesikar have?

Substitutes

Generics, in the structure of which solifenacin is included, is considered the medicine "Zevesin".

To cheap analogues of "Vesicar" include:

1. "Novitropan".
2. "Driptan."
3. "Detruzitol".
4. "Urotol".

Before replacing the drug, consult a specialist. The cost of the studied medication varies from 800 to 1300 rubles.

"Urotol" or "Vesikar", which is better

A medication with antidysuric, as well as m-anticholinergic action. According to the annotation, “Urotol” is recommended to eliminate bladder hyperreflexia, which manifests itself in the form of frequent urges to urinate, urine incontinence.

Tablets are taken orally, regardless of food. Recommended drug concentration: 2 mg twice daily.

"Urotol" is considered a cheap analogue of "Vesikar". This is the advantage of the drug, its cost. The effectiveness of "Urotol" is no worse than that of "Vesikar".

With individual tolerance, a single dosage can be reduced to 1 mg. In the same dose, the medication is prescribed for diseases of the liver and kidneys. The cost of the drug varies from 500 to 700 rubles.

"Detruzitol"

Blocker of m-cholinergic receptors, lowering the tone of the smooth muscles of the urinary tract. The drug is suitable for the treatment of bladder hyperactivity, which are characterized by increased urination.

Detrusitol is a cheap analogue of Vesicar. Before therapy with Detrusitol, a patient should be examined to exclude the organic causes of frequent urination. The daily concentration of the drug must be reduced to 2 mg if necessary, the simultaneous use of antibiotics of the macrolide group, as well as antifungal agents.

The medication should not be prescribed to children, since the safety of its use in this age group of people has not been fully studied. Representatives of childbearing age should use contraception during therapy.

There are few comments on Detrusitol. Many of them tell about the increased effectiveness of the medication. It is noted that when using long-acting capsules in comparison with treatment with tablets, the pharmacological effect is more pronounced.

Adverse reactions are reported extremely rarely. Dry mouth, as a rule, is unexpressed. The cost is from 500 to 700 rubles.

"Driptan" or "Vesikar", which is better?

The drug is a medicine whose pharmacological effect is aimed at lowering the tone of the smooth muscles of the urinary tract. The medication is available in tablets.

Driptan is recommended with extreme caution to people with kidney or liver disease. And also to persons who suffer from cardiac ischemia, hyperthyroidism, arterial hypertension, benign prostatic hyperplasia.

In the first three months of pregnancy, “Driptan” is not recommended for women, since there is no reliable information on the safety of the components of the drug on the fetus, in addition, in the first twelve weeks all important organs and systems of the unborn baby are laid, and the use of any medication can adversely affect this process. The price of a medicine ranges from 600 to 900 rubles.

Novitropan

An antispasmodic that affects the frequency of urination and is effective for urinary incontinence. Available in tablet form.

The drug has antispasmodic effectiveness, with the help of which it helps to eliminate stenosis and reduces the tone of the smooth muscles of the biliary tract, gastrointestinal tract, uterus, exerting myotropic and m-anticholinergic effects. The medication increases the injectivity of the bladder, reduces the frequency of involuntary contractions and restrains the urge to urinate.

Children and the elderly, Novitropan is recommended to use, taking special care. In addition to this, precautions should be observed with autonomic neuropathy, severe disorders of gastric motility, and liver diseases.

In case of damage to the gastrointestinal tract, the use of anticholinergic drugs can weaken the motility of the digestive system, which should be taken into account in the treatment of patients with intestinal atony and ulcerative colitis. The cost of Novitropan is 600 rubles.

Spazmeks

The medicine has an antispasmodic effect, which helps to reduce the tone of the smooth muscles of the bladder. What is more effective - "Spazmeks" or "Vesikar"? Both drugs act in the same direction. That one, that the second medication has the same pharmacological activity. The cost of Spazmeks is much cheaper than that of Vesikar - it starts at 300 and ends with 900 rubles.

Zevesin

The medication refers to antagonists of cholinergic receptors. As a rule, Zevesin is prescribed for patients who suffer from bladder hyperactivity.

The average cost of the drug is 3800 rubles. "Zevesin" is necessary for the treatment of frequent urination, urine incontinence, which are recorded in people with high activity syndrome. The drug is consumed whole, washed down with water. Zevesin is taken regardless of food.

Storage conditions

"Vesikar" should be kept away from moisture and the sun, away from children, at a temperature of no more than 25 degrees. Shelf life is three years. It is not recommended to use the drug at the end of the shelf life. Vesikar has no Russian analogues.

Opinions

Responses about “Vesikar” on medical Internet resources tell that the medication could not prove itself as the most effective remedy for urinary incontinence. Most patient reviews do not report onset of relief after taking the drug. In addition, most people report frequent adverse reactions. From the reviews it is known that cheap analogues of "Vesicar" without side effects do not exist.

But there is information about the situation when the best result was noted precisely after the use of the studied medication.

It must be remembered that the treatment of overactive bladder syndrome is considered complex, and largely depends on the individuality of each organism.