Currently, the pharmaceutical market has a huge variety of drugs that are used to treat diseases of the gastrointestinal tract. So, one of the most modern drugs is the Nolpaza remedy, which can eliminate the increased acidity of the stomach. The production of this medicine is carried out by the pharmaceutical company KRKA (Slovenia).
Structure
Instructions for use "Nolpazy" contains information that in one tablet may contain 20 or 40 mg of pantoprazole (in the form of sodium salt) - the main component, due to which the drug has a therapeutic effect.
The remaining components are excipients. These include sorbitol, mannitol and salts (calcium stearate, sodium carbonate).
Mechanism of action
The active substance of the drug is pantoprazole. This is a representative of the latest generation of proton pump inhibitors.
The mechanism of action of the drug is that it prevents the development of an enzyme responsible for the transport of hydrogen ions into the lumen of the stomach. If there are few of them, then hydrochloric acid simply is not produced. As a result, the environment of the stomach does not become very acidic. This is the therapeutic effect of Nolpase.
It is worth noting that the medicine does not completely eliminate the acid, the environment of the stomach will still remain below 7, but within acceptable limits.
Release form
The drug is available in the form of tablets, which are coated with an enteric coating.
The dosage forms and the number of tablets in one package differ. Nolpase is 20 mg and 40 mg pantoprazole in each pill.
Tablets, in turn, are packed in blisters and cardboard boxes of 14, 28 or 56 pieces.
There is another form of release of the drug - lyophilisate for the preparation of an injection solution. Its use is relevant in severe clinical cases, as well as in chronic pathological processes in the digestive system.
Pharmacodynamics
"Nolpase" is used orally, then pantoprazole is excreted from the tablet and absorbed into the systemic circulation.
The bioavailability of the drug is quite high and is approximately 75-80%. Moreover, it does not depend on food intake.
The maximum concentration of the drug component is detected in the body after 2 hours.
Pantoprazole is almost completely dissolved in the liver, after which it is excreted in the urine and partially with feces (about 5%).
Indications for use
Due to its effective mechanism of action, the drug is used for:
- An ulcer of the stomach and intestines, in the area of the duodenum.
- Zollinger-Ellison syndrome is a disease in which there are benign tumors in certain cells of the pancreas.
- In addition, Nolpaza can be used in combination with antibacterial agents to kill the bacteria Helicobacter pylori.
- Reflux esophagitis, an inflammatory process on the mucous membrane of the esophagus, also refers to indications.
Contraindications
Nolpase is prohibited for use by patients suffering from digestive disorders due to any neurotic problems. When using the drug in this case, the situation can only worsen.
In addition, before starting taking the drug, one should exclude such a diagnosis as malignant neoplasms of the gastrointestinal tract, otherwise Nolpaza will eliminate the symptoms of oncology, thereby delaying its detection. Therefore, with cancer of the digestive system, this medicine is prohibited.
Another contraindication is hypersensitivity to any component of the medication. Otherwise, lightning-fast development of a powerful allergic reaction is possible.
Use during pregnancy and during breastfeeding
As a rule, doctors prescribe this drug to pregnant women, but only in case of urgent need, given the possible risks for the unborn child.
According to the information from the complete Nolpazy instructions, it is forbidden to take the drug while breastfeeding. The fact is that pantoprazole passes into breast milk and can have a negative effect on the baby's body.
Negative reactions
And what can be said about the side effects of Nolpaza? Like any other drug, a medicine is capable of, to one degree or another, exert a negative effect on various organs and systems. As a result, a certain number of side effects may develop. "Nolpaza" can cause violations:
- From the digestive system: nausea, bloating, diarrhea, epigastric pain.
- Side effects "Nolpaza" can cause and from the nervous system. This usually manifests itself in the form of headache and dizziness.
- The skin also suffers. Since the appearance of a rash, itching is possible.
- It is extremely rare, but depression, edema, and fever to subfebrile values are possible.
When are the side effects of Nolpazy detected? This usually occurs during the first week of treatment. Patients begin to complain of a rash, headache, and so on.
As a rule, all side effects of Nolpazy quickly disappear after dose adjustment or drug withdrawal.
Dosage and route of administration
If Nolpaza is used orally, the tablet, regardless of the dosage chosen, should be swallowed whole, and then washed down with a sufficient amount of clean drinking water. Usually enough half a glass of liquid.
Chew, dissolve the tablet is not necessary. This will disrupt the release of the drug. After all, it is extremely important that the drug is released from the lumen of the stomach, and not in the oral cavity.
Although there is no particular connection between food intake and the use of the drug, it is better to drink a pill immediately before meals.
If the treatment regimen prescribed by the doctor suggests that you need to drink one tablet per day, it is better to do this in the morning, immediately before breakfast.
For patients suffering from reflux esophagitis, the doctor usually prescribes 20 mg of pantoprazole per day at a time. The duration of the course is set individually for each patient, but usually does not exceed one month. Although in some cases a person is forced to take the medicine for two months.
If there is a high probability of relapse, then the dose is temporarily increased to 40 mg for 1-2 weeks, after which the dosage is again reduced to 20 mg per day.
There is a category of people who are forced to use drugs of the group of non-steroidal anti-inflammatory drugs (ibuprofen, dexalgin and others) for a long time that have a negative effect on the walls of the gastrointestinal tract. In order to protect the digestive organs, such people are prescribed 20 mg of pantoprazole per day.
In order to destroy Helicobacter pylori "Nolpaza" should be used in conjunction with antibiotic therapy, 40 mg 2 times a day.
The highest doses are indicated for patients suffering from Zollinger-Ellison syndrome and similar diseases in which there is a particularly strong secretion of hydrochloric acid. The treatment regimens for such conditions are double doses of 40 mg. If necessary, the patient may be prescribed 80 mg 2 times a day.
It should be borne in mind that if the patient has any disturbances in the liver, then he is shown no more than 20 mg of pantoprazole per day.
Be sure to exclude the presence of malignant tumors in the stomach and esophagus before starting treatment.
Instructions for the use of injections "Nolpazy" states that the drug should be prepared immediately before administration.
Pantoprazole powder should be dissolved in 10 ml of 0.9% sodium chloride (saline) and administered intravenously. In addition, the introduction of the drug is permissible drip. For this, the drug must be mixed with 100 ml of saline or 5% glucose solution.
It is very important to start the injection of the drug 2-15 minutes after the preparation of the solution. Also, this dosage form should be resorted to only with insufficient effectiveness of the oral form.
Pharmacy Vacation Terms
"Nolpase", containing 40 mg of pantoprazole, refers to drugs dispensed only as directed by a doctor. Therefore, the drug is not available in the buyer's access. Before selling the medicine, the pharmacist or pharmacist will surely ask the patient for a prescription form of a strictly defined form, check it for correct design and then release the drug.
"Nolpaza" with a dosage of 20 mg can be sold without a prescription.
Terms and conditions of storage
Nolpaza should be stored in a dry place, away from direct sunlight. Air temperature should not be lower than 15 and not higher than 30 degrees.
It is extremely important that these tablets are out of the reach of small children.
Under appropriate conditions, the product can be stored for two years from the date of manufacture.
Reviews
Why is Nolpaz prescribed most often? As a rule, for the treatment of peptic ulcer of the stomach and intestines.
If we study the patient reviews of this drug in detail, we can conclude that about 70% of them are positive.
Most people who have been treated with this medication claim that the drug really effectively eliminates unpleasant symptoms. Improvement of well-being occurs within a day or two after the start of medication.
The main disadvantages that can be found in reviews of Nolpaz are side effects, which are sometimes quite pronounced. A small percentage of patients had to stop taking the drug or reduce its dosage.
The second disadvantage is the high cost of treatment. Indeed, in the pharmaceutical market there are cheaper drugs with a similar, but not similar effect.
However, there is no doubt whether the drug will justify its cost. After all, pantoprazole is one of the most effective substances that reduce the acidity of the stomach. In this case, this tool causes not very pronounced side effects.
The therapeutic effect is especially noticeable when using an injectable form of the drug. According to reviews, the action is noticeable after one or two injections. However, do not forget that this method of applying "Nolpaza" is permissible only in extreme cases and only when prescribed by a doctor. In addition, the side effects of "Nolpaza" in the form of injections, as a rule, manifest themselves more pronounced.
Therapists and gastroenterologists respond positively to the drug, prescribing it to their patients with various diseases and syndromes. They choose the drug because:
- We are confident in its quality.
- It suits most patients.
- Patients do not begin to complain that the doctor prescribes the most expensive remedy. This favorably affects the reputation of a specialist.
- The drug rarely causes severe side effects.
The necessary dosage of "Nolpazy" and the correct dosage regimen provide the most pronounced therapeutic effect with a minimum of negative consequences.
Drug cost
The price depends on the dosage chosen and the form of release. So, the more pantoprazole is contained in one tablet and the more these tablets are more in the package, the higher the cost.
Nolpaza 20 mg:
- 14 tablets - 130-180 rubles.
- 28 pills - 240-290 rubles.
- 56 tablets - 350-400 rubles.
Nolpaza 40 mg:
- 14 tablets - 200-250 rubles.
- 28 pills - 380-430 rubles.
- 56 tablets - 580-630 rubles.
Analogs
"Nolpaza" refers to those drugs that have a wide selection of structural analogues.
Medicines whose active ingredient is pantoprazole include drugs such as:
- "Controlok" (Germany).
- Sanpraz (India).
- Ultra (Russia).
All these drugs have the same indications and contraindications, side effects and dosage regimens. In addition, they all relate to prescription drugs.
They differ among themselves by the manufacturer and pricing policy. As a rule, Russian and Indian medicines are cheaper than their German relatives.
So, for example, “Kontrolok” will cost the buyer 300-350 rubles for 14 tablets containing 20 mg of pantoprazole in each. And at 590-640 rubles - for 28 tablets of 40 mg.
Sanpraz will cost about 470-520 rubles per 1 pack containing 30 tablets of 40 mg each.
Thus, we can conclude that Nolpaza is in the middle price category.
Conclusion
The drug to which this article is devoted is an effective tool to reduce the acidity of the stomach. However, before starting the appointment, you should get a doctor’s appointment, familiarize yourself with the contraindications and side effects of Nolpaza.
The fact is that the tool has a systemic effect on the human body, so in rare cases it can cause certain complications. Another disadvantage of the tool is its price.
Analogs of "Nolpazy" are quite widely represented on pharmacy shelves, which allows the patient to choose the best option among all representatives of pantoprazole. Nevertheless, according to the results of the study of analogues, it can be concluded that Nolpaza represents the optimal ratio of quality and price among preparations containing pantoprazole.