For only 50 rubles, you can buy Milgamma in pharmacies. The tool is used as an element of the complex treatment of various nervous syndromes, diseases. In the instructions for use "Milgammu", the manufacturer recommends for neuritis, paresis, neuralgia, neuro-, polyneuro-, plexopathy and ganglionitis, osteochondrosis and convulsions at night. The latter is especially true for elderly patients. "Milgamma" is indicated for use at different ages: the drug is prescribed for both children and adults. There are several forms of release. For the most pronounced effect, the drug is used strictly on the recommendation of a doctor and in accordance with the manufacturer's instructions.
general information
The instructions for use of "Milgamma" indicate that the product belongs to the category of multivitamins. On pharmacy shelves, it is presented in the form of a solution, which is injected into the muscle tissue, as well as tablets (dragees) and cream.
"Milgamma" can not be used if installed:
- hypersensitivity to the components of the drug;
- insufficiency of the functioning of the heart in a chronic decompensated form;
- pregnancy;
- breast-feeding.
In the form of injections, Milgamma is not used for children.
Features of use
The manufacturer recommends injecting deep into muscle tissue. If therapy is necessary against a background of severe pain, it is necessary to use Milgamma in such a way as to quickly achieve a high level of concentration of active compounds in the circulatory system. For this, the course of treatment is subject to the following rules:
- dosage - 2 ml;
- frequency - twice a day;
- the duration of the program is from five days to twice as much time.
When relieving pain, the instructions for use of Milgamma recommend switching to a drug for oral use or injecting with a reduced frequency - no more than three times a week. The duration of this course is up to three weeks. A similar approach requires mild forms of the disease. The doctor may recommend lowering the frequency of injecting the drug first, and then switch to tablets.
Instructions for use "Milgamma" draws the attention of patients to the affiliation of funds to:
- analgesics;
- metabolic stimulants;
- drugs that protect the nervous system.
How it works?
The effectiveness of the medication is due to the presence in its composition of vitamins of group B necessary for the nervous system, indispensable to prevent degeneration of the nervous tissue, stopping inflammatory processes. Vitamins have a positive effect on the condition of the musculoskeletal system.
Once in the body, thiamine, pyridoxine affect each other, mutually activating the effect. Both substances have a positive effect on the state of the NS, the neuromuscular system. Cyanocobalamin is necessary for the processes of production of the myelin sheath. Once in the human body, this component relieves pain due to damage to the PNS. The substance activates the metabolism of nucleic acids, since it stimulates the action of folic acid.
Instructions for use "Milgamma Composite" draws attention to the presence of lidocaine. This tool has a local effect, relieves pain.
Side effects
The manufacturer mentions the possibility of an allergic reaction. She expressed:
- increased sweat production;
- increased heart rate;
- acne;
- itchy patches of skin;
- urticaria.
It is known that Milgamma can cause hypersensitivity reactions that manifest themselves:
- skin rash;
- angioedema;
- complicated breathing;
- anaphylactic shock.
Instructions for the use of "Milgamma" in ampoules recommends administering the drug slowly enough. If you violate this rule, there is a possibility of systemic side effects:
- violation of the rhythm of the heartbeat;
- seizure
- dizziness.
In a similar way, an overdose of Milgamma may manifest itself. An excess of the drug in the body manifests itself by activation of side effects. When observing such a reaction, treatment is stopped and measures are taken to eliminate unpleasant symptoms.
The nuances of using
As indicated in the instructions for use, injections "Milgamma" are intended for intramuscular administration by a qualified specialist. The procedure should be monitored by the attending physician. If the symptoms are severe enough, hospitalization of the patient is required and the injection is strictly by hospital staff.
Clinical observations did not show changes in the ability to concentrate, to control high-precision mechanisms under the influence of Milgamma injections. Instructions for use indicate that for the period of the course there is no need to limit labor activity, to avoid driving.
Chemistry chemistry
Upon contact with sulfite-containing substances, thiamine instantly decomposes. Once in contact with the breakdown products of this vitamin, other components of the drug also lose activity. Levodopa stops the influence of B6. The use of "Milgamma" in the form of injections in combination with epinephrine, norepinephrine can cause an additional load on the cardiac system, as a result, the activation of side effects. This is due to the presence of lidocaine in the composition of the drug. Epinephrine and norepinephrine are strictly prohibited if an excess of the permissible dose of local anesthetics is established.
Instructions for the use of injections "Milgamma" contains a mention of the impossibility of the simultaneous use of the drug and reducing, initiating oxidation reactions of substances. These include:
- mercury chloride;
- tannic acid;
- sodium phenobarbital;
- metabisulfite;
- iodide;
- ammonium citrate and iron;
- benzylpenicillin;
- carbonate;
- riboflavin;
- acetate;
- dextrose.
To activate the processes of destruction of thiamine are capable of copper ions. Thiamine deactivation is observed with an increase in the acidity of the medium above pH 3.
Cobalamin (B12) is not compatible with heavy metal salts. The combination of thiamine, cobalamin and other vitamins from the same group in one solution can lead to rapid deactivation of the composition under the influence of thiamine decay products. To prevent such a reaction, the introduction of iron ions in a low concentration is necessary.
The instructions for the use of injections of Milgamma mention the negative effect of riboflavin on other components of the composition if the substance is exposed to direct sunlight. Photolysis proceeds faster due to nicotinamide, and this process can be somewhat slowed down by introducing antioxidants into the substance.
Dynamics
In the instructions for the use of injections "Milgamma" intramuscularly it is recommended to resort to the composition, if a person does not receive the necessary amount of trace elements, vitamin compounds with food. In different forms of release, Milgamma is suitable for people who need an increased amount of trace elements and vitamins due to diseases. To alleviate the condition of the patient, but not harm the body, the use of the substance should be agreed with the attending physician. The doctor selects the form of the drug, determines the dosage and duration of the course.
The instructions for the use of Milgamma injections (reviews note that the drug is prescribed in this form quite often, although with a recommendation in the future to switch to the oral form), it is indicated that the thiamine present in the medication is extremely important for the metabolic processes of carbohydrates. Vitamin takes part in the Krebs cycle, in the production of ATP, thiamine pyrophosphate.
Pyridoxine is no less important for the human body, since it is indispensable for the metabolic processes of protein structures, and to some extent controls the metabolism of fats and carbohydrates. The analgesic lidocaine provides all types of anesthesia available to modern medicine:
- terminal;
- conductor;
- infiltration.
Kinetics
In the instructions for use of "Milgamma" intramuscularly, the manufacturer indicates that soon after ingestion, thiamine is absorbed into the circulatory system. Studies have shown that on the first day of the therapeutic course with the introduction of the drug in an amount of 50 mg, after a quarter of an hour in the circulatory system, the concentration of thiamine reaches 484 ng / ml. In the tissues and organs of the body, thiamine is distributed unevenly. One tenth of the proportion is observed in blood plasma, 15% accumulate in white blood cells, and the predominant part (about 75%) - in red blood cells.
A distinctive feature of thiamine is the lack of reserves of this component in the human body. To maintain health, it is necessary to ensure daily intake of the compound. It is known that a substance is able to penetrate the placenta, the blood-brain barrier, into breast milk.
Thiamine is excreted from the body with urine after 0.15 hours in the alpha phase, beta - after an hour. The conclusion of the terminal phase requires two days. The instructions for the use of injections "Milgamma" intramuscularly (reviews indicate that the manufacturer provides an understandable and complete description of the drug) indicated metabolites of thiamine:
- pyramine;
- thiamincarboxylic acid.
The manufacturer admits that there are other metabolites. At present, their nature, chemical formula have not yet been established.
Studies have shown that thiamine is stored in minimal (compared to other vitamins) in the body. Normally, in the body of an adult, not more than 30 mg of a substance in the form of pyrophosphate (80% of thiamine is responsible for it), about one tenth of the amount is given to triphosphate, and the rest to monophosphate.
Pyridoxine: Kinetics
As follows from the instructions for use "Milgamma" (2 ml - the dosage form of the drug), shortly after administration of the composition, pyridoxine is injected into the circulatory system, redistributed in the tissues and organs of the body. Pyridoxine plays the role of coenzyme. The predominant part (about 80%) reacts with plasma proteins. Studies have shown that pyridoxine passes through the placenta, excreted in breast milk. Transformation processes occur in the liver, while 4-pyridoxic acid is formed, leaving the body with urine. Duration of excretion is from two hours to five. Normally, the body contains pyridoxine in an amount of 40-150 mg. Elimination is estimated at 1.7-3.6 mg; replenishment - about 2.3%.
Milgamma Cream
In the instructions for use of "Milgamma" (reviews confirm that the product works well) it is mentioned that in the form of a cream, the drug shows a moisturizing effect. The product is intended for the treatment of legs. The main active component of the drug is urea, which is able to retain moisture in the skin. This is a completely natural compound, which in healthy skin is contained in a concentration of about one percent. Often, dry skin is due to a reduced amount of urea.
According to reviews, Milgamma (instructions for use during use must be followed exactly) is often prescribed by dermatologists. In medicine, urea has long been known as a reliable composition with a good reputation and a minimum of side effects. A cream containing urea helps to retain moisture by binding it, which means that it does not allow the skin to dry out. In this case, itching passes, the surfaces become softer. On the one hand, the skin becomes more susceptible to moisture, while the ability to accumulate fluid increases.
Milgamma ointment is created from urea and base. This minimizes the likelihood of allergies, skin irritations, makes the drug effective and safe, useful for the skin.
Application features
The ointment helps to soften the skin and increase their elasticity, relieve the sensation of itching. In addition to the feet, Milgamma is suitable for the treatment of knees, elbows. Under the influence of the cream, regeneration processes are activated, the skin structure is quickly restored.
The manufacturer does not use dyes, does not use aromatic additives, preservatives, so that the drug is as safe as possible and suitable for allergy sufferers.
Milgamma Dragee
Instructions for use of the drug in this form contain mention of such active substances:
- pyridoxine hydrochloride;
- benfotiamine.
Both components are added in an amount of 100 mg per dose.
Additionally, the manufacturer used auxiliary components:
- starch;
- cellulose;
- acacia powder;
- talc;
- wax;
- sucrose;
- povidone;
- polyethylene glycol;
- calcium carbonate;
- glycerides.
Two formats are on sale: 30 and 60 capsules in one package. Be sure to complete the instructions for use with the Milgamma, Milgamma Composite tablets. Reviews of these formulations confirm: the drug is often prescribed for both adults and children. It very rarely provokes allergic reactions, but it significantly improves the condition of people suffering from vitamin deficiency in the body.
Terms of use
Milgamma tablets according to the instructions for use are used in a monthly course. A single dose is one capsule. You can use Milgamma for food up to three times a day. Drink plenty of water with each dose. A fairly common practice is the beginning of a therapeutic course with injections, followed by the transition to the oral form. The manufacturer recommends changing the application for dragees as quickly as possible.
According to reviews, Milgamma tablets (the instructions for use will have to be observed so as not to encounter side effects) are often prescribed if:
- paresis;
- neuritis;
- neuralgia;
- plexo-, polyneuro-, neuropathies;
- shingles and other ganglionites.
Side effects
The use of Milgamma can cause:
- vomiting
- nausea
- allergic reactions;
- acne
- convulsions
- dizziness.
Against the background of taking the drug in extremely rare cases, there is a likelihood of confusion, brady, tachycardia, arrhythmia.
Is there an alternative?
If there is a need to replace the drug, you should first consult with your doctor. We examined in detail the instructions for use of the Milgamma. Analogues of the drug may be:
- “Undevit”;
- "Hexavit";
- The Vetoron.
Your doctor may recommend Revit. A good reputation is distinguished by the composition of “Gendevit”.
Regardless of whether you choose to use Milgamma, analogues, instructions for the use of tablets, injections, solutions, it is important to follow very accurately, otherwise the likelihood of side effects increases. If allergic reactions are known, it is necessary to warn the doctor about this at the stage of prescribing. The doctor will immediately advise which of the pharmaceutical products you can choose if Milgamma provokes a negative response from the body.
Undevit: an analogue of injections Milgamma
Instructions for use of this drug contain an indication of a sufficiently large complex of vitamins in the composition. Undevit includes:
- tocopherol;
- pyridoxine;
- riboflavin;
- vitamin C;
- retinol;
- nicotinamide;
- calcium;
- folic acid;
- thiamine;
- rutoside;
- cyanocobalamin.
As an additional component, the manufacturer used peppermint essential oil.
On sale “Undevit” is represented by cardboard boxes containing instructions for use and a plastic container with 50 tablets.
Pharmacology
Undevita components work as follows:
- retinol activates the production of rhodopsin, cartilage, bone, epithelium;
- thiamine stimulates carbohydrate metabolism, normalizes the work of NS;
- pyridoxine affects amino acid biochemical reactions, histamine;
- riboflavin normalizes tissue respiration;
- nicotinamide is indispensable for metabolic and respiratory processes;
- cyanocobolamine stimulates blood formation, myelin production;
- Vitamin C is involved in the production of hemoglobin, collagen, red blood cells, stimulates blood coagulation, increases immunity;
- routine reduces tissue permeability;
- folic acid is needed for metabolic processes involving choline, nucleins, amino acids;
- tocopherol is involved in protein production processes, is an antioxidant;
- calcium is necessary for coenzyme synthesis.
Recommendations for use
The manufacturer advises the use of “Undevit” for a lack of vitamins in the body, as well as for:
- the need to maintain immunity during the course of taking antimicrobial drugs;
- recovery from a serious illness;
- the need for stimulation of metabolic processes during the growth and development of children and adolescents.
“Undevit” is recommended for improving the general condition of the body of an adult, an elderly person.
The manufacturer draws attention to the fact that "Undevit" (like other multivitamin complexes) does not have a specific pharmacological effect. The preparation contains vitamins necessary for a person, and their dosage is close to the daily norm. . «» , .
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Contraindications and adverse reactions
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Terms of use
The manufacturer recommends the use of Undevit capsules after a meal. To prevent a lack of vitamins in the body, the drug is used orally one tablet daily. With significant loads, during the recovery period after an illness, surgical intervention for a day, the use of two to three servings is recommended. The manufacturer recommends a similar dosage to the elderly.
Duration of admission is 20-30 days. Between repeated courses, a pause is required; a break - from a month to a quarter of a year.
Undevit is allowed from the age of 14. As a prophylactic composition, it is used on a capsule daily, as an element of complex therapy - 2-3 doses daily.
An excess of the drug can manifest itself as nausea, vomiting and impaired stool. Possible allergies, lethargy, irritability. Against the background of an overdose, “Undevitum" may hurt the head, stomach, and possibly impaired liver function. When observing such manifestations, the reception is stopped, they turn to the doctor for a choice of symptomatic treatment.
Mutual influence
Studies have shown that retinol and tocopherol have a mutual stimulating effect. Vitamin A reduces the activity of glucocorticoids relative to foci of inflammation. Do not use a multivitamin complex and nitrites, cholestyramines that interfere with the normal absorption of retinol. Vitamin A is not compatible with retinoids.
The increased iron content in some drugs does not allow tocopherol to affect the human body. Therefore, the multivitamin complex should not be combined with medicines on silver, iron. Do not combine Undevit and trisamine, sodium bicarbonate, since the increased alkalinity of the medium, formed under their influence, does not allow tocopherol to be absorbed. Inhibit the effectiveness of the vitamin and medications that indirectly affect blood coagulation.
Ascorbic acid activates penicillins, sulfonamides, leading to an increase in the toxicity of these compounds. The simultaneous use of heparin, indirect anticoagulants and vitamin C leads to a decrease in the effectiveness of the first two. Ascorbic acid stimulates the absorption of iron. The combination of the vitamin complex and oral contraceptives reduces the bioavailability of the vitamin.