Osteoarthrosis is called degenerative joint disease. Its cause of development is damage to the cartilage tissue located on the articular surfaces. This pathological condition can occur due to injuries, dysplasia and inflammation.
Quite often, this disease is inherited. It also develops due to overweight, in old age and due to a specific profession.
To restore cartilage on articular surfaces, doctors prescribe special medications to patients. One of them is the Kondronova medication. The price of this medicine will be presented later. Also in the materials of this article you will find instructions for the use of this drug, its properties, analogues, release form and contraindications.
Composition, shape and packaging
In what form is the Kondronova medication made? Customer reviews say that this medicine is available in capsules. They are placed in blisters or contained in jars of PVC (placed in cardboard boxes).
What substances does the Kondronova preparation contain? The tablets have the following active ingredients: glucosamine sulfate and chondroitin sulfate.
It should also be said that the composition of the drug in question includes auxiliary ingredients in the form of mannitol, magnesium stearate, croscarmellose sodium and purified talc.
The capsule shell consists of water, gelatin, sodium lauryl sulfate, povidone, bronopol, dye titanium dioxide, dye blue diamond and dye quinoline yellow.
Mechanism of action
What are Kondronova capsules? Instructions for use reports that this is a tool that stimulates the regeneration of cartilage. Its effectiveness is due to the components that make up the composition.
Chondroitin and glucosamine sulfate are involved in the synthesis of connective tissues, and also help prevent the destruction of cartilage and stimulate regeneration.
The use of exogenous glucosamine improves the production of cartilage matrix, providing it with non-specific protection against possible chemical damage.
Glucosamine in the form of a sulfate salt is a precursor of hexosamine. As for the sulfate anion, it is required for the synthesis of glycosaminoglycans.
It should also be noted that another function of glucosamine is to protect damaged cartilage from metabolic damage caused by taking GCS and NSAIDs. In addition, this substance has a moderate anti-inflammatory effect.
What other properties does the Kondronova medicine have? Capsules containing chondroitin sulfate are an additional tool for the formation of healthy cartilage. This fact does not depend on whether the drug is absorbed in an intact form or in the form of individual elements.
It cannot be said that the substance mentioned can stimulate the formation of hyaluronon, type II collagen and the synthesis of proteoglycans, as well as protect hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase) and the damaging effects of free radicals.
According to experts, chondroitin sulfate not only maintains the viscosity of the synovial fluid, but also stimulates the repair mechanisms of cartilage, inhibiting the activity of those components that break it down (for example, elastase or hyaluronidase).
So what is remarkable about the Kondronova medication? Reviews say that with the treatment of osteoarthritis, it significantly alleviates the symptoms of the disease and reduces the need for patients to take NSAIDs.
Kinetics of medication
Consider the kinetic properties of each component in more detail.
The oral bioavailability of this substance is 25%.
It is distributed in the tissues. Maximum element concentrations are found in articular cartilage, liver and kidneys. About 30% of the dose taken is persistent in muscle and bone tissue for a long time.
Glucosamine is excreted along with urine and feces within 68 hours.
Taking this element inside at a dosage of 800 mg contributes to an increase in its concentration in the blood during the day. Absolute bioavailability is 12%. About 10% and 20% of the dose taken is absorbed in the form of high molecular weight metabolites and low molecular weight derivatives.
Chondroitin sulfate is excreted in the urine within 5 hours.
Indications
What diseases are prescribed Kondronova capsules? Instructions for use indicate that this tool is actively used for the treatment of stage 1-3 osteoarthrosis.
Contraindications
When should you not take Kondronova tablets, the analogues of which are listed below? According to the instructions, contraindications to the use of this medication are the following:
- the presence of hypersensitivity;
- pregnancy period;
- phenylketonuria;
- breastfeeding time;
- minor age.
Capsules "Kondronova": instructions for use
The doctor should tell the patient how to take the medication in question. Only an experienced specialist, relying on the analysis data and the general information of a medical examination, will be able to choose the right treatment regimen and prescribe effective treatment.
According to the instructions, capsules for osteoarthrosis of stage 1-3 should be taken only inside. Such medical procedures should be carried out 25 minutes before eating. In this case, the drug must be washed down with one glass of water.
For adult patients, this drug is usually prescribed in the amount of two capsules twice or thrice a day.
The duration of treatment with the drug "Kondronova" is 1-2 months. If required, then repeat the course.
Side effects
What undesirable reactions can the Kondronova medication cause? Instructions for use indicate that its active components affect the patient's body in different ways.
Side effects when taking capsules may be:
- Due to chondroitin: allergic reactions.
- Due to glucosamine: violation of the digestive tract (flatulence, epigastric pain, constipation or, conversely, diarrhea), allergic skin reactions, dizziness, leg pain, headache, peripheral edema, tachycardia, drowsiness and insomnia.
Drug Interactions and Overdoses
The drug "Kondronova" increases the absorption of tetracyclines, and also worsens the effect of glucosamine and semisynthetic penicillins. In addition, this medication is compatible with GCS and NSAIDs.
Symptoms of an overdose of Kondronova are unknown.
Kondronova capsules: price and similar products
Depending on the number of capsules in the package, the drug in question may have different prices (from 290 rubles).
If this medication is contraindicated to the patient, then it is replaced with one of such drugs as Chondrogluxide, Teraflex or Arthra.
Reviews
Consumer reviews about this medication are mostly positive. Patients claim that this tool significantly improves the condition of the joints, and therefore the pain associated with osteoarthritis is eliminated.
Experienced experts fully agree with the opinion of consumers. They more than once became convinced of the high efficiency and effectiveness of the mentioned drug. It restores cartilage and reduces the patient's need for NSAIDs.